Rac2 regulates immune complex-mediated granule polarization and exocytosis in neutrophils

A key molecule for neutrophil degranulation is Rac2 guanosine triphosphatase. Neutrophils from Rac2 knockout mice (Rac2-/-) exhibit impaired primary granule exocytosis in response to cytochalasin B/f-Met-Leu-Phe, while secondary and tertiary granule release is unaffected. Coronin 1A, a protein invol...

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Veröffentlicht in:	Journal of leukocyte biology 2023-07, Vol.114 (2), p.116-125
Hauptverfasser:	Ilarraza, Ramses, Chao, Danny V, Bodman, James A R, Chesley, Alexandra, Humble, Adam, Shaheen, Farzana, Eitzen, Gary, Lacy, Paige
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Antigen-Antibody Complex - metabolism Cytochalasin B - metabolism Cytoplasmic Granules - metabolism Exocytosis Humans Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Mice Mice, Knockout N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - metabolism Peroxidase - metabolism RAC2 GTP-Binding Protein
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