Secondary Structure in Overcoming Photosensitizers’ Aggregation: α‐Helical Polypeptides for Enhanced Photodynamic Therapy

Aggregation caused quenching (ACQ) effect can severely inhibit the application of hydrophobic photosensitizers (PSs) bearing planar and rigid structures. Most of the reported cases utilized random‐coiled polymers for the in vivo delivery of PSs, which would inevitably aggravate ACQ effect due to the...

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Veröffentlicht in:	Advanced healthcare materials 2023-08, Vol.12 (21), p.e2203386-n/a
Hauptverfasser:	Xu, Xiang, Ma, Jinjuan, Zheng, Yubin, Wang, Shaolei, Wang, Aiguo, Zheng, Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation caused quenching Conformation Fluorescence Hydrophobicity Molecular chains Molecular dynamics PDT Photodynamic therapy Phototoxicity Polymers Polypeptides Protein structure Reactive oxygen species Rigid structures Secondary structure secondary structures α‐helical polypeptides π‐π stacking interaction
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