Primary Pediatric Yolk Sac Tumor of Liver With Lung Metastasis: An Unusual Presentation With Diagnosis Aided by LIN28 Immunohistochemistry
Yolk sac tumor is a malignant germ cell tumor, which typically occurs in the gonads with elevated serum alpha-fetoprotein (AFP). Among extragonadal sites, the liver is an uncommon location for primary pediatric yolk sac tumors. Other common hepatic tumors in this age group presenting with elevated s...
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| Veröffentlicht in: | International journal of surgical pathology 2023-12, Vol.31 (8), p.1618-1625 |
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| container_title | International journal of surgical pathology |
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| creator | Sekar, Mithraa Devi Pradeep, Immanuel Srinivas, Bheemanathi Hanuman Toi, Pampa Ch Govindarajan, Krishnakumar Kayal, Smita |
| description | Yolk sac tumor is a malignant germ cell tumor, which typically occurs in the gonads with elevated serum alpha-fetoprotein (AFP). Among extragonadal sites, the liver is an uncommon location for primary pediatric yolk sac tumors. Other common hepatic tumors in this age group presenting with elevated serum AFP like hepatoblastoma and hepatocellular carcinoma must be differentiated from yolk sac tumors for initiating appropriate treatment and accurate prognostication. Lung metastasis with refractoriness to chemotherapy is an extraordinary presentation that has never been documented in the literature. We report our experience with a 2-year-old female child initially misdiagnosed as hepatoblastoma. It was found that LIN28 positivity by immunohistochemistry aided in confirmation of the histopathological diagnosis of primary yolk sac tumor of the liver. |
| doi_str_mv | 10.1177/10668969231157777 |
| format | Article |
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It was found that LIN28 positivity by immunohistochemistry aided in confirmation of the histopathological diagnosis of primary yolk sac tumor of the liver.</description><subject>Immunohistochemistry</subject><subject>Liver</subject><subject>Lung cancer</subject><subject>Metastasis</subject><subject>Tumors</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kV1rFTEQhhex2Fr9Ad5IwBtvts3Hbj68O9SvA1s9YIt4taTJ7Dmpu0mbbITzF_zVpmyroDgMzECeeSfMW1UvCD4hRIhTgjmXiivKCGlFiUfVEVENrmnD28elL-_1HXBYPU3pGmNMOSVPqkMmMGGspUfVz010k457tAHr9BydQd_C-B190QZd5ClEFAbUuR8Q0Vc371CX_Radw6xTSZfeoJVHlz6nrEe0iZDAz3p2wS_0W6e3PhQOrZwFi672qFt_ohKtpyn7sHNpDmYHU6lx_6w6GPSY4Pl9Pa4u37-7OPtYd58_rM9WXW0Yl3NNlRkwUYxhISTh2nIqOW2sxIYANxZADGZQRvKGDEIpwSSRjFoG1gDjDTuuXi-6NzHcZkhzX_YbGEftIeTUU6FaxgmTvKCv_kKvQ46-_K6nUjblhkS2hSILZWJIKcLQ3yxH7Qnu74zq_zGqzLy8V85XE9jfEw_OFOBkAZLewp-1_1f8BQZimn4</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Sekar, Mithraa Devi</creator><creator>Pradeep, Immanuel</creator><creator>Srinivas, Bheemanathi Hanuman</creator><creator>Toi, Pampa Ch</creator><creator>Govindarajan, Krishnakumar</creator><creator>Kayal, Smita</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9652-0179</orcidid><orcidid>https://orcid.org/0000-0002-4832-2047</orcidid></search><sort><creationdate>20231201</creationdate><title>Primary Pediatric Yolk Sac Tumor of Liver With Lung Metastasis: An Unusual Presentation With Diagnosis Aided by LIN28 Immunohistochemistry</title><author>Sekar, Mithraa Devi ; Pradeep, Immanuel ; Srinivas, Bheemanathi Hanuman ; Toi, Pampa Ch ; Govindarajan, Krishnakumar ; Kayal, Smita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-29cf01933077816ad628624d80c1e6cdee7fcf9c8641f7997381832d3edce3643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Immunohistochemistry</topic><topic>Liver</topic><topic>Lung cancer</topic><topic>Metastasis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sekar, Mithraa Devi</creatorcontrib><creatorcontrib>Pradeep, Immanuel</creatorcontrib><creatorcontrib>Srinivas, Bheemanathi Hanuman</creatorcontrib><creatorcontrib>Toi, Pampa Ch</creatorcontrib><creatorcontrib>Govindarajan, Krishnakumar</creatorcontrib><creatorcontrib>Kayal, Smita</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sekar, Mithraa Devi</au><au>Pradeep, Immanuel</au><au>Srinivas, Bheemanathi Hanuman</au><au>Toi, Pampa Ch</au><au>Govindarajan, Krishnakumar</au><au>Kayal, Smita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary Pediatric Yolk Sac Tumor of Liver With Lung Metastasis: An Unusual Presentation With Diagnosis Aided by LIN28 Immunohistochemistry</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>31</volume><issue>8</issue><spage>1618</spage><epage>1625</epage><pages>1618-1625</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><abstract>Yolk sac tumor is a malignant germ cell tumor, which typically occurs in the gonads with elevated serum alpha-fetoprotein (AFP). 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| subjects | Immunohistochemistry Liver Lung cancer Metastasis Tumors |
| title | Primary Pediatric Yolk Sac Tumor of Liver With Lung Metastasis: An Unusual Presentation With Diagnosis Aided by LIN28 Immunohistochemistry |
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