Potential use of the cholesterol transfer inhibitor U18666A as an antiviral drug for research on various viral infections
Cholesterol plays critical functions in arranging the biophysical attributes of proteins and lipids in the plasma membrane. For various viruses, an association with cholesterol for virus entrance and/or morphogenesis has been demonstrated. Therefore, the lipid metabolic pathways and the combination...
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| Veröffentlicht in: | Microbial pathogenesis 2023-06, Vol.179, p.106096-106096, Article 106096 |
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| creator | Assefi, Marjan Bijan Rostami, Reza Ebrahimi, Menooa Altafi, Mana Tehrany, Pooya M. Zaidan, Haider Kamil Talib Al-Naqeeb, Bashar Zuhair Hadi, Meead Yasamineh, Saman Gholizadeh, Omid |
| description | Cholesterol plays critical functions in arranging the biophysical attributes of proteins and lipids in the plasma membrane. For various viruses, an association with cholesterol for virus entrance and/or morphogenesis has been demonstrated. Therefore, the lipid metabolic pathways and the combination of membranes could be targeted to selectively suppress the virus replication steps as a basis for antiviral treatment. U18666A is a cationic amphiphilic drug (CAD) that affects intracellular transport and cholesterol production. A robust tool for investigating lysosomal cholesterol transfer and Ebola virus infection is an androstenolone derived termed U18666A that suppresses three enzymes in the cholesterol biosynthesis mechanism. In addition, U18666A inhibited low-density lipoprotein (LDL)-induced downregulation of LDL receptor and triggered lysosomal aggregation of cholesterol. According to reports, U18666A inhibits the reproduction of baculoviruses, filoviruses, hepatitis, coronaviruses, pseudorabies, HIV, influenza, and flaviviruses, as well as chikungunya and flaviviruses. U18666A-treated viral infections may act as a novel in vitro model system to elucidate the cholesterol mechanism of several viral infections. In this article, we discuss the mechanism and function of U18666A as a potent tool for studying cholesterol mechanisms in various viral infections.
•Potential use of the cholesterol transfer inhibitor.•U18666A as an antiviral drug for research on various viral infections. |
| doi_str_mv | 10.1016/j.micpath.2023.106096 |
| format | Article |
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•Potential use of the cholesterol transfer inhibitor.•U18666A as an antiviral drug for research on various viral infections.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2023.106096</identifier><identifier>PMID: 37011734</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Anti-viral drug ; Anticholesteremic Agents - pharmacology ; antiviral agents ; Antiviral Agents - pharmacology ; Aujeszky disease ; Baculoviridae ; biosynthesis ; Cholesterol ; Ebolavirus ; Flaviviridae ; Hemorrhagic Fever, Ebola ; hepatitis ; Humans ; influenza ; low density lipoprotein ; low density lipoprotein receptors ; morphogenesis ; NPC1 ; Orthocoronavirinae ; pathogenesis ; physiological transport ; plasma membrane ; reproduction ; U18666A ; Viral infection ; virus replication ; viruses</subject><ispartof>Microbial pathogenesis, 2023-06, Vol.179, p.106096-106096, Article 106096</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-7fd01f99b45ac10349317edb5e6b778f53be00db9f2d4fa962f295e77aa5f77b3</citedby><cites>FETCH-LOGICAL-c398t-7fd01f99b45ac10349317edb5e6b778f53be00db9f2d4fa962f295e77aa5f77b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0882401023001298$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37011734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Assefi, Marjan</creatorcontrib><creatorcontrib>Bijan Rostami, Reza</creatorcontrib><creatorcontrib>Ebrahimi, Menooa</creatorcontrib><creatorcontrib>Altafi, Mana</creatorcontrib><creatorcontrib>Tehrany, Pooya M.</creatorcontrib><creatorcontrib>Zaidan, Haider Kamil</creatorcontrib><creatorcontrib>Talib Al-Naqeeb, Bashar Zuhair</creatorcontrib><creatorcontrib>Hadi, Meead</creatorcontrib><creatorcontrib>Yasamineh, Saman</creatorcontrib><creatorcontrib>Gholizadeh, Omid</creatorcontrib><title>Potential use of the cholesterol transfer inhibitor U18666A as an antiviral drug for research on various viral infections</title><title>Microbial pathogenesis</title><addtitle>Microb Pathog</addtitle><description>Cholesterol plays critical functions in arranging the biophysical attributes of proteins and lipids in the plasma membrane. For various viruses, an association with cholesterol for virus entrance and/or morphogenesis has been demonstrated. Therefore, the lipid metabolic pathways and the combination of membranes could be targeted to selectively suppress the virus replication steps as a basis for antiviral treatment. U18666A is a cationic amphiphilic drug (CAD) that affects intracellular transport and cholesterol production. A robust tool for investigating lysosomal cholesterol transfer and Ebola virus infection is an androstenolone derived termed U18666A that suppresses three enzymes in the cholesterol biosynthesis mechanism. In addition, U18666A inhibited low-density lipoprotein (LDL)-induced downregulation of LDL receptor and triggered lysosomal aggregation of cholesterol. According to reports, U18666A inhibits the reproduction of baculoviruses, filoviruses, hepatitis, coronaviruses, pseudorabies, HIV, influenza, and flaviviruses, as well as chikungunya and flaviviruses. U18666A-treated viral infections may act as a novel in vitro model system to elucidate the cholesterol mechanism of several viral infections. In this article, we discuss the mechanism and function of U18666A as a potent tool for studying cholesterol mechanisms in various viral infections.
•Potential use of the cholesterol transfer inhibitor.•U18666A as an antiviral drug for research on various viral infections.</description><subject>Animals</subject><subject>Anti-viral drug</subject><subject>Anticholesteremic Agents - pharmacology</subject><subject>antiviral agents</subject><subject>Antiviral Agents - pharmacology</subject><subject>Aujeszky disease</subject><subject>Baculoviridae</subject><subject>biosynthesis</subject><subject>Cholesterol</subject><subject>Ebolavirus</subject><subject>Flaviviridae</subject><subject>Hemorrhagic Fever, Ebola</subject><subject>hepatitis</subject><subject>Humans</subject><subject>influenza</subject><subject>low density lipoprotein</subject><subject>low density lipoprotein receptors</subject><subject>morphogenesis</subject><subject>NPC1</subject><subject>Orthocoronavirinae</subject><subject>pathogenesis</subject><subject>physiological transport</subject><subject>plasma membrane</subject><subject>reproduction</subject><subject>U18666A</subject><subject>Viral infection</subject><subject>virus replication</subject><subject>viruses</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LHCEQhiUkZCeb_IQEj7n0xI9W21NYls0HLCSH7Flsu0w79OhE7YH993HpSa4LQoE8VaXvg9B7SvaUUPnpsD8Gd7J13jPCeLuTRMsXaEdb6Sgjw0u0I8PAup5QcoXelHIghOie69foiitCqeL9Dj3-TBViDXbBawGcPK4zYDenBUqFnBZcs43FQ8YhzmEMNWX8QAcp5Q22BdvYTg3nkNuEKa-_sW9AhgI2uxmniM82h7QWvCEhenA1pFjeolfeLgXeXeo1evhy9-v2W3f_4-v325v7znE91E75iVCv9dgL6yjhveZUwTQKkKNSgxd8BEKmUXs29d5qyTzTApSyVnilRn6NPm5zTzn9WduvzDEUB8tiI7R3GTbwnrX4BHseVVpwofUgGyo21OVUSgZvTjkcbX40lJgnQeZgLoLMkyCzCWp9Hy4r1vEI0_-uf0Ya8HkDoGVyDpBNcQGigynklpyZUnhmxV_-laUW</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Assefi, Marjan</creator><creator>Bijan Rostami, Reza</creator><creator>Ebrahimi, Menooa</creator><creator>Altafi, Mana</creator><creator>Tehrany, Pooya M.</creator><creator>Zaidan, Haider Kamil</creator><creator>Talib Al-Naqeeb, Bashar Zuhair</creator><creator>Hadi, Meead</creator><creator>Yasamineh, Saman</creator><creator>Gholizadeh, Omid</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>202306</creationdate><title>Potential use of the cholesterol transfer inhibitor U18666A as an antiviral drug for research on various viral infections</title><author>Assefi, Marjan ; Bijan Rostami, Reza ; Ebrahimi, Menooa ; Altafi, Mana ; Tehrany, Pooya M. ; Zaidan, Haider Kamil ; Talib Al-Naqeeb, Bashar Zuhair ; Hadi, Meead ; Yasamineh, Saman ; Gholizadeh, Omid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-7fd01f99b45ac10349317edb5e6b778f53be00db9f2d4fa962f295e77aa5f77b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Anti-viral drug</topic><topic>Anticholesteremic Agents - pharmacology</topic><topic>antiviral agents</topic><topic>Antiviral Agents - pharmacology</topic><topic>Aujeszky disease</topic><topic>Baculoviridae</topic><topic>biosynthesis</topic><topic>Cholesterol</topic><topic>Ebolavirus</topic><topic>Flaviviridae</topic><topic>Hemorrhagic Fever, Ebola</topic><topic>hepatitis</topic><topic>Humans</topic><topic>influenza</topic><topic>low density lipoprotein</topic><topic>low density lipoprotein receptors</topic><topic>morphogenesis</topic><topic>NPC1</topic><topic>Orthocoronavirinae</topic><topic>pathogenesis</topic><topic>physiological transport</topic><topic>plasma membrane</topic><topic>reproduction</topic><topic>U18666A</topic><topic>Viral infection</topic><topic>virus replication</topic><topic>viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Assefi, Marjan</creatorcontrib><creatorcontrib>Bijan Rostami, Reza</creatorcontrib><creatorcontrib>Ebrahimi, Menooa</creatorcontrib><creatorcontrib>Altafi, Mana</creatorcontrib><creatorcontrib>Tehrany, Pooya M.</creatorcontrib><creatorcontrib>Zaidan, Haider Kamil</creatorcontrib><creatorcontrib>Talib Al-Naqeeb, Bashar Zuhair</creatorcontrib><creatorcontrib>Hadi, Meead</creatorcontrib><creatorcontrib>Yasamineh, Saman</creatorcontrib><creatorcontrib>Gholizadeh, Omid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Assefi, Marjan</au><au>Bijan Rostami, Reza</au><au>Ebrahimi, Menooa</au><au>Altafi, Mana</au><au>Tehrany, Pooya M.</au><au>Zaidan, Haider Kamil</au><au>Talib Al-Naqeeb, Bashar Zuhair</au><au>Hadi, Meead</au><au>Yasamineh, Saman</au><au>Gholizadeh, Omid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential use of the cholesterol transfer inhibitor U18666A as an antiviral drug for research on various viral infections</atitle><jtitle>Microbial pathogenesis</jtitle><addtitle>Microb Pathog</addtitle><date>2023-06</date><risdate>2023</risdate><volume>179</volume><spage>106096</spage><epage>106096</epage><pages>106096-106096</pages><artnum>106096</artnum><issn>0882-4010</issn><eissn>1096-1208</eissn><abstract>Cholesterol plays critical functions in arranging the biophysical attributes of proteins and lipids in the plasma membrane. For various viruses, an association with cholesterol for virus entrance and/or morphogenesis has been demonstrated. Therefore, the lipid metabolic pathways and the combination of membranes could be targeted to selectively suppress the virus replication steps as a basis for antiviral treatment. U18666A is a cationic amphiphilic drug (CAD) that affects intracellular transport and cholesterol production. A robust tool for investigating lysosomal cholesterol transfer and Ebola virus infection is an androstenolone derived termed U18666A that suppresses three enzymes in the cholesterol biosynthesis mechanism. In addition, U18666A inhibited low-density lipoprotein (LDL)-induced downregulation of LDL receptor and triggered lysosomal aggregation of cholesterol. According to reports, U18666A inhibits the reproduction of baculoviruses, filoviruses, hepatitis, coronaviruses, pseudorabies, HIV, influenza, and flaviviruses, as well as chikungunya and flaviviruses. U18666A-treated viral infections may act as a novel in vitro model system to elucidate the cholesterol mechanism of several viral infections. In this article, we discuss the mechanism and function of U18666A as a potent tool for studying cholesterol mechanisms in various viral infections.
•Potential use of the cholesterol transfer inhibitor.•U18666A as an antiviral drug for research on various viral infections.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37011734</pmid><doi>10.1016/j.micpath.2023.106096</doi><tpages>1</tpages></addata></record> |
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| ispartof | Microbial pathogenesis, 2023-06, Vol.179, p.106096-106096, Article 106096 |
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| subjects | Animals Anti-viral drug Anticholesteremic Agents - pharmacology antiviral agents Antiviral Agents - pharmacology Aujeszky disease Baculoviridae biosynthesis Cholesterol Ebolavirus Flaviviridae Hemorrhagic Fever, Ebola hepatitis Humans influenza low density lipoprotein low density lipoprotein receptors morphogenesis NPC1 Orthocoronavirinae pathogenesis physiological transport plasma membrane reproduction U18666A Viral infection virus replication viruses |
| title | Potential use of the cholesterol transfer inhibitor U18666A as an antiviral drug for research on various viral infections |
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