Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification

Calcific aortic valve disease (CAVD) is characterized by a phenotypic switch of valvular interstitial cells to bone-forming cells. Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition receptors at the interface between innate immunity and tissue repair. Type I interferons (IFN...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2023-05, Vol.147 (20), p.1518-1533
Hauptverfasser:	Gollmann-Tepeköylü, Can, Graber, Michael, Hirsch, Jakob, Mair, Sophia, Naschberger, Andreas, Pölzl, Leo, Nägele, Felix, Kirchmair, Elke, Degenhart, Gerald, Demetz, Egon, Hilbe, Richard, Chen, Hao-Yu, Engert, James C., Böhm, Anna, Franz, Nadja, Lobenwein, Daniela, Lener, Daniela, Fuchs, Christiane, Weihs, Anna, Töchterle, Sonja, Vogel, Georg F., Schweiger, Victor, Eder, Jonas, Pietschmann, Peter, Seifert, Markus, Kronenberg, Florian, Coassin, Stefan, Blumer, Michael, Hackl, Hubert, Meyer, Dirk, Feuchtner, Gudrun, Kirchmair, Rudolf, Troppmair, Jakob, Krane, Markus, Weiss, Günther, Tsimikas, Sotirios, Thanassoulis, George, Grimm, Michael, Rupp, Bernhard, Huber, Lukas A., Zhang, Shen-Ying, Casanova, Jean-Laurent, Tancevski, Ivan, Holfeld, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Aortic Valve - pathology Aortic Valve Stenosis - pathology Biglycan - metabolism Calcinosis - metabolism Cells, Cultured Humans Mice Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - metabolism Zebrafish
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