Topical Cream Carrying Drug-Loaded Nanogels for Melanoma Treatment
In this study, nanogel creams carrying paclitaxel (PTX) and temozolomide (TMZ) were prepared for the topical treatment of melanoma. PTX and TMZ were first loaded in poly-(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly-(D,L-lactide-co-glycolide) (PLAG-b-PEG-b-PLGA) thermosensitive n...
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| Veröffentlicht in: | Pharmaceutical research 2023-10, Vol.40 (10), p.2291-2301 |
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| creator | Rahman, Sadia Haque, Tasmima N. Sugandhi, Vrashabh V. Saraswat, Aishwarya L. Xin, Xiaoban Cho, Hyunah |
| description | In this study, nanogel creams carrying paclitaxel (PTX) and temozolomide (TMZ) were prepared for the topical treatment of melanoma. PTX and TMZ were first loaded in poly-(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly-(D,L-lactide-co-glycolide) (PLAG-b-PEG-b-PLGA) thermosensitive nanogels, which made a transition from a free-flowing sol (formation of micellar network) at 25°C with the z-average particle size of c.a. 96 nm to a gel (aggregation of micelles) at 33°C with the z-average particle size of c.a. 427 nm. An anhydrous absorption ointment base, aquaphor, was then added to drug-loaded nanogels to form nanogel creams carrying PTX and TMZ. Nanogel creams permitted controlled release of the payloads and improved the penetration of the payloads through the rodent skin compared to drug(s)-loaded nanogels. PTX and TMZ in a combination were synergistically effective in inhibiting SK-MEL28, A375, and B16-F10 melanoma cancer cells
in vitro
. Topically applied nanogel creams carrying TMZ/PTX (4 mg/1.5 mg/dose) showed a trend of tumor volume inhibition on B16-F10-bearing xenograft mice
in vivo
. |
| doi_str_mv | 10.1007/s11095-023-03506-z |
| format | Article |
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in vitro
. Topically applied nanogel creams carrying TMZ/PTX (4 mg/1.5 mg/dose) showed a trend of tumor volume inhibition on B16-F10-bearing xenograft mice
in vivo
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in vitro
. Topically applied nanogel creams carrying TMZ/PTX (4 mg/1.5 mg/dose) showed a trend of tumor volume inhibition on B16-F10-bearing xenograft mice
in vivo
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PTX and TMZ were first loaded in poly-(D,L-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly-(D,L-lactide-co-glycolide) (PLAG-b-PEG-b-PLGA) thermosensitive nanogels, which made a transition from a free-flowing sol (formation of micellar network) at 25°C with the z-average particle size of c.a. 96 nm to a gel (aggregation of micelles) at 33°C with the z-average particle size of c.a. 427 nm. An anhydrous absorption ointment base, aquaphor, was then added to drug-loaded nanogels to form nanogel creams carrying PTX and TMZ. Nanogel creams permitted controlled release of the payloads and improved the penetration of the payloads through the rodent skin compared to drug(s)-loaded nanogels. PTX and TMZ in a combination were synergistically effective in inhibiting SK-MEL28, A375, and B16-F10 melanoma cancer cells
in vitro
. Topically applied nanogel creams carrying TMZ/PTX (4 mg/1.5 mg/dose) showed a trend of tumor volume inhibition on B16-F10-bearing xenograft mice
in vivo
.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37012533</pmid><doi>10.1007/s11095-023-03506-z</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-7150-4191</orcidid></addata></record> |
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| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Cell Line, Tumor Controlled release Dermatologic agents Dermatology Drug Carriers Drug therapy Formulae, receipts, prescriptions Humans Medical Law Melanoma Melanoma - drug therapy Mice Micelles Nanogels Original Research Article Paclitaxel Particle size Pharmacology/Toxicology Pharmacy Polyethylene glycol Polyethylene Glycols Polylactide-co-glycolide Skin Temozolomide |
| title | Topical Cream Carrying Drug-Loaded Nanogels for Melanoma Treatment |
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