Enhanced Lyn Activity Causes Severe, Progressive Emphysema and Lung Cancer

The epidemiological patterns of incident chronic obstructive pulmonary disease (COPD) and lung adenocarcinoma are changing, with an increasing fraction of disease occurring in patients who are never-smokers or were not exposed to traditional risk factors. However, causative mechanism(s) are obscure....

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2023-07, Vol.69 (1), p.99-112
Hauptverfasser:	Tsantikos, Evelyn, Gottschalk, Timothy A, L'Estrange-Stranieri, Elan, O'Brien, Caitlin A, Raftery, April L, Wickramasinghe, Lakshanie C, McQualter, Jonathan L, Anderson, Gary P, Hibbs, Margaret L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma of Lung - genetics Age Cancer Cell differentiation Cell proliferation Chimeras Chronic obstructive pulmonary disease Emphysema Endothelium Epidermal growth factor receptors Epithelial cells Epithelium ErbB Receptors - metabolism Humans Inflammation Lung cancer Lung diseases Lung Neoplasms - genetics Macrophages Microvasculature Myeloid cells Obstructive lung disease Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Emphysema - genetics Pulmonary fibrosis src-Family Kinases - metabolism
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