IMPACT OF STATINS ON THE CLINICAL COURSE OF COVID-19-ASSOCIATED PNEUMONIA IN UNVACCINATED PATIENTS WITH ARTERIAL HYPERTENSION
The aim: To assess the impact of statins on the severity and lethality rate in hypertensive patients with COVID-19-associated pneumonia. Materials and methods: 106 unvaccinated hypertensive patients were enrolled in the study. 29 (27.4%) patients took statins. Results: Statins were not associated wi...
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| Veröffentlicht in: | Wiadomości lekarskie (1960) 2023, Vol.76 (2), p.311-319 |
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| container_title | Wiadomości lekarskie (1960) |
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| creator | Skakun, Oleksiy Z |
| description | The aim: To assess the impact of statins on the severity and lethality rate in hypertensive patients with COVID-19-associated pneumonia.
Materials and methods: 106 unvaccinated hypertensive patients were enrolled in the study. 29 (27.4%) patients took statins.
Results: Statins were not associated with reduced risks of lethality (relative risk (RR), 0.24; [95%CI, 0.03-1.79], p=0.16), decline in oxygen saturation |
| doi_str_mv | 10.36740/WLek202302110 |
| format | Article |
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Materials and methods: 106 unvaccinated hypertensive patients were enrolled in the study. 29 (27.4%) patients took statins.
Results: Statins were not associated with reduced risks of lethality (relative risk (RR), 0.24; [95%CI, 0.03-1.79], p=0.16), decline in oxygen saturation <92% during the inpatient stay (RR, 0.70 [95%CI, 0.39-1.28], p=0.25) and need for supplemental oxygen (RR, 0.84; [95%CI, 0.51-1.37], p=0.48). There was no significant difference in the median length of in-hospital stay between the patients taking statins (14.0 [10.0-15.0] days) and patients, which didn't take statins (13.0 [9.0-18.0] days) (p=0.76). However, subgroup analysis showed that statins reduced the risk of decline in oxygen saturation <92% in patients aged 65 years and older with body mass index $ 25.0 kg/m2 (RR, 0.33 [95%CI, 0.11-0.92], p=0.03).
Conclusions: Statins didn't a#ect the severity and lethality rate in hypertensive patients with COVID-19-associated pneumonia. Subgroup analysis showed that statin use was associated with a decrease in morbidity of patients aged 65 years and older with BMI $25.0 kg/m2 hospitalized for COVID-19-associated pneumonia.</description><identifier>ISSN: 0043-5147</identifier><identifier>DOI: 10.36740/WLek202302110</identifier><identifier>PMID: 37010167</identifier><language>eng</language><publisher>Poland</publisher><subject>COVID-19 - complications ; Disease Progression ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Hypertension - complications ; Hypertension - drug therapy ; Pneumonia - drug therapy ; Pneumonia - etiology</subject><ispartof>Wiadomości lekarskie (1960), 2023, Vol.76 (2), p.311-319</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c165t-8db7ff358eeb5f3feb4ccbf54dca0a19cf5f1f43938b90de6bbaa43f749a98473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37010167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skakun, Oleksiy Z</creatorcontrib><title>IMPACT OF STATINS ON THE CLINICAL COURSE OF COVID-19-ASSOCIATED PNEUMONIA IN UNVACCINATED PATIENTS WITH ARTERIAL HYPERTENSION</title><title>Wiadomości lekarskie (1960)</title><addtitle>Wiad Lek</addtitle><description>The aim: To assess the impact of statins on the severity and lethality rate in hypertensive patients with COVID-19-associated pneumonia.
Materials and methods: 106 unvaccinated hypertensive patients were enrolled in the study. 29 (27.4%) patients took statins.
Results: Statins were not associated with reduced risks of lethality (relative risk (RR), 0.24; [95%CI, 0.03-1.79], p=0.16), decline in oxygen saturation <92% during the inpatient stay (RR, 0.70 [95%CI, 0.39-1.28], p=0.25) and need for supplemental oxygen (RR, 0.84; [95%CI, 0.51-1.37], p=0.48). There was no significant difference in the median length of in-hospital stay between the patients taking statins (14.0 [10.0-15.0] days) and patients, which didn't take statins (13.0 [9.0-18.0] days) (p=0.76). However, subgroup analysis showed that statins reduced the risk of decline in oxygen saturation <92% in patients aged 65 years and older with body mass index $ 25.0 kg/m2 (RR, 0.33 [95%CI, 0.11-0.92], p=0.03).
Conclusions: Statins didn't a#ect the severity and lethality rate in hypertensive patients with COVID-19-associated pneumonia. Subgroup analysis showed that statin use was associated with a decrease in morbidity of patients aged 65 years and older with BMI $25.0 kg/m2 hospitalized for COVID-19-associated pneumonia.</description><subject>COVID-19 - complications</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Hypertension - complications</subject><subject>Hypertension - drug therapy</subject><subject>Pneumonia - drug therapy</subject><subject>Pneumonia - etiology</subject><issn>0043-5147</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkD1PwzAQhj2AaAVdGZFHlhQ7dj48Rq5LLKVO1TitmKJ82FKhpSVpBwb-OyktSNxyJ91zz0kvAPcYjYkfUPS0Ssybi1yCXIzRFRgiRInjYRoMwKjrXlFfvoeRz27AgAQII-wHQ_AlZ_OIa5hOYaYjLVUGUwV1LCBPpJI8SiBP80UmTgRPl3LiYOZEWZZyGWkxgXMl8lmqZASlgrlaRpxLdd70OqF0BldSxzBaaLGQvS5-mYt-VplM1R24tuWmM6NLvwX5VGgeO0n6fPrt1Nj3Dk7YVIG1xAuNqTxLrKloXVfWo01dohKz2noWW0oYCSuGGuNXVVlSYgPKShbSgNyCx7N33-4-jqY7FNt1V5vNpnw3u2NXuAGjPqMIsx4dn9G63XVda2yxb9fbsv0sMCp-ki7-Jd0fPFzcx2prmj_8N2PyDSWhcaY</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Skakun, Oleksiy Z</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2023</creationdate><title>IMPACT OF STATINS ON THE CLINICAL COURSE OF COVID-19-ASSOCIATED PNEUMONIA IN UNVACCINATED PATIENTS WITH ARTERIAL HYPERTENSION</title><author>Skakun, Oleksiy Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c165t-8db7ff358eeb5f3feb4ccbf54dca0a19cf5f1f43938b90de6bbaa43f749a98473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>COVID-19 - complications</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Hypertension - complications</topic><topic>Hypertension - drug therapy</topic><topic>Pneumonia - drug therapy</topic><topic>Pneumonia - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skakun, Oleksiy Z</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Wiadomości lekarskie (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skakun, Oleksiy Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IMPACT OF STATINS ON THE CLINICAL COURSE OF COVID-19-ASSOCIATED PNEUMONIA IN UNVACCINATED PATIENTS WITH ARTERIAL HYPERTENSION</atitle><jtitle>Wiadomości lekarskie (1960)</jtitle><addtitle>Wiad Lek</addtitle><date>2023</date><risdate>2023</risdate><volume>76</volume><issue>2</issue><spage>311</spage><epage>319</epage><pages>311-319</pages><issn>0043-5147</issn><abstract>The aim: To assess the impact of statins on the severity and lethality rate in hypertensive patients with COVID-19-associated pneumonia.
Materials and methods: 106 unvaccinated hypertensive patients were enrolled in the study. 29 (27.4%) patients took statins.
Results: Statins were not associated with reduced risks of lethality (relative risk (RR), 0.24; [95%CI, 0.03-1.79], p=0.16), decline in oxygen saturation <92% during the inpatient stay (RR, 0.70 [95%CI, 0.39-1.28], p=0.25) and need for supplemental oxygen (RR, 0.84; [95%CI, 0.51-1.37], p=0.48). There was no significant difference in the median length of in-hospital stay between the patients taking statins (14.0 [10.0-15.0] days) and patients, which didn't take statins (13.0 [9.0-18.0] days) (p=0.76). However, subgroup analysis showed that statins reduced the risk of decline in oxygen saturation <92% in patients aged 65 years and older with body mass index $ 25.0 kg/m2 (RR, 0.33 [95%CI, 0.11-0.92], p=0.03).
Conclusions: Statins didn't a#ect the severity and lethality rate in hypertensive patients with COVID-19-associated pneumonia. Subgroup analysis showed that statin use was associated with a decrease in morbidity of patients aged 65 years and older with BMI $25.0 kg/m2 hospitalized for COVID-19-associated pneumonia.</abstract><cop>Poland</cop><pmid>37010167</pmid><doi>10.36740/WLek202302110</doi><tpages>9</tpages></addata></record> |
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| ispartof | Wiadomości lekarskie (1960), 2023, Vol.76 (2), p.311-319 |
| issn | 0043-5147 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | COVID-19 - complications Disease Progression Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hypertension - complications Hypertension - drug therapy Pneumonia - drug therapy Pneumonia - etiology |
| title | IMPACT OF STATINS ON THE CLINICAL COURSE OF COVID-19-ASSOCIATED PNEUMONIA IN UNVACCINATED PATIENTS WITH ARTERIAL HYPERTENSION |
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