Regulation and function of poised mRNAs in lymphocytes
Pre‐existing but untranslated or ‘poised’ mRNA exists as a means to rapidly induce the production of specific proteins in response to stimuli and as a safeguard to limit the actions of these proteins. The translation of poised mRNA enables immune cells to express quickly genes that enhance immune re...
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| Veröffentlicht in: | BioEssays 2023-05, Vol.45 (5), p.e2200236-n/a |
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| description | Pre‐existing but untranslated or ‘poised’ mRNA exists as a means to rapidly induce the production of specific proteins in response to stimuli and as a safeguard to limit the actions of these proteins. The translation of poised mRNA enables immune cells to express quickly genes that enhance immune responses. The molecular mechanisms that repress the translation of poised mRNA and, upon stimulation, enable translation have yet to be elucidated. They likely reflect intrinsic properties of the mRNAs and their interactions with trans‐acting factors that direct poised mRNAs away from or into the ribosome. Here, I discuss mechanisms by which this might be regulated.
Poised transcripts are messenger RNAs that are not being translated but can be translated in response to stimuli. In lymphocytes poised transcripts encode cytokines and other proteins involved in cell fate. Candidate mechanisms for reversible transcript poising involving RNA binding proteins and the chemical, structural or spatial modification of mRNA are considered here. |
| doi_str_mv | 10.1002/bies.202200236 |
| format | Article |
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Poised transcripts are messenger RNAs that are not being translated but can be translated in response to stimuli. In lymphocytes poised transcripts encode cytokines and other proteins involved in cell fate. Candidate mechanisms for reversible transcript poising involving RNA binding proteins and the chemical, structural or spatial modification of mRNA are considered here.</description><identifier>ISSN: 0265-9247</identifier><identifier>EISSN: 1521-1878</identifier><identifier>DOI: 10.1002/bies.202200236</identifier><identifier>PMID: 37009769</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>3' Untranslated Regions ; 5' Untranslated Regions ; Animals ; cytokines ; Gene Expression Regulation ; Humans ; Immune response ; Immune system ; Immunity ; immunological memory ; Lymphocytes ; Lymphocytes - immunology ; Lymphocytes - metabolism ; Molecular modelling ; mRNA ; poised transcript ; Protein Biosynthesis ; Proteins ; RNA ; RNA binding proteins ; RNA, Messenger - chemistry ; RNA, Messenger - metabolism ; Translation</subject><ispartof>BioEssays, 2023-05, Vol.45 (5), p.e2200236-n/a</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC.</rights><rights>2023 The Authors. BioEssays published by Wiley Periodicals LLC.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4136-c4a774416345cdb58b2391d817b8d3c9df3da32b30a3ec6879d72308b36d48ff3</citedby><cites>FETCH-LOGICAL-c4136-c4a774416345cdb58b2391d817b8d3c9df3da32b30a3ec6879d72308b36d48ff3</cites><orcidid>0000-0002-3801-9896</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbies.202200236$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbies.202200236$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37009769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turner, Martin</creatorcontrib><title>Regulation and function of poised mRNAs in lymphocytes</title><title>BioEssays</title><addtitle>Bioessays</addtitle><description>Pre‐existing but untranslated or ‘poised’ mRNA exists as a means to rapidly induce the production of specific proteins in response to stimuli and as a safeguard to limit the actions of these proteins. The translation of poised mRNA enables immune cells to express quickly genes that enhance immune responses. The molecular mechanisms that repress the translation of poised mRNA and, upon stimulation, enable translation have yet to be elucidated. They likely reflect intrinsic properties of the mRNAs and their interactions with trans‐acting factors that direct poised mRNAs away from or into the ribosome. Here, I discuss mechanisms by which this might be regulated.
Poised transcripts are messenger RNAs that are not being translated but can be translated in response to stimuli. In lymphocytes poised transcripts encode cytokines and other proteins involved in cell fate. 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immunology</topic><topic>Lymphocytes - metabolism</topic><topic>Molecular modelling</topic><topic>mRNA</topic><topic>poised transcript</topic><topic>Protein Biosynthesis</topic><topic>Proteins</topic><topic>RNA</topic><topic>RNA binding proteins</topic><topic>RNA, Messenger - chemistry</topic><topic>RNA, Messenger - metabolism</topic><topic>Translation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turner, Martin</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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The translation of poised mRNA enables immune cells to express quickly genes that enhance immune responses. The molecular mechanisms that repress the translation of poised mRNA and, upon stimulation, enable translation have yet to be elucidated. They likely reflect intrinsic properties of the mRNAs and their interactions with trans‐acting factors that direct poised mRNAs away from or into the ribosome. Here, I discuss mechanisms by which this might be regulated.
Poised transcripts are messenger RNAs that are not being translated but can be translated in response to stimuli. In lymphocytes poised transcripts encode cytokines and other proteins involved in cell fate. Candidate mechanisms for reversible transcript poising involving RNA binding proteins and the chemical, structural or spatial modification of mRNA are considered here.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37009769</pmid><doi>10.1002/bies.202200236</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-3801-9896</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 3' Untranslated Regions 5' Untranslated Regions Animals cytokines Gene Expression Regulation Humans Immune response Immune system Immunity immunological memory Lymphocytes Lymphocytes - immunology Lymphocytes - metabolism Molecular modelling mRNA poised transcript Protein Biosynthesis Proteins RNA RNA binding proteins RNA, Messenger - chemistry RNA, Messenger - metabolism Translation |
| title | Regulation and function of poised mRNAs in lymphocytes |
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