Study of the Allosteric Mechanism of Human Mitochondrial Phenylalanyl-tRNA Synthetase by Transfer Entropy via an Improved Gaussian Network Model and Co-evolution Analyses

We propose an improved transfer entropy approach called the dynamic version of the force constant fitted Gaussian network model based on molecular dynamics ensemble (dfcfGNMMD) to explore the allosteric mechanism of human mitochondrial phenylalanyl-tRNA synthetase (hmPheRS), one of the aminoacyl-tRN...

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Veröffentlicht in:	The journal of physical chemistry letters 2023-04, Vol.14 (14), p.3452-3460
Hauptverfasser:	Han, Zhongjie, Wang, Xiaoli, Wu, Zhixiang, Li, Chunhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acyl-tRNA Synthetases - chemistry Amino Acyl-tRNA Synthetases - genetics Amino Acyl-tRNA Synthetases - metabolism Anticodon Catalytic Domain Entropy Humans Phenylalanine-tRNA Ligase - chemistry Phenylalanine-tRNA Ligase - genetics Phenylalanine-tRNA Ligase - metabolism Physical Insights into Materials and Molecular Properties
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