Rare manifestations of monoclonal gammopathies: About two clinical cases and literature review
Monoclonal gammopathies are common over the age of 50. Patients are usually asymptomatic. However, some patients present with secondary clinical manifestations, which are now grouped under the entity « Monoclonal Gammopathy of Clinical Significance » (MGCS). Here, we report two rare cases of MGCS: a...
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| Veröffentlicht in: | La revue de medecine interne 2023-06, Vol.44 (6), p.307-310 |
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| container_title | La revue de medecine interne |
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| creator | Perlot, Q Hermans, C Vekemans, M-C |
| description | Monoclonal gammopathies are common over the age of 50. Patients are usually asymptomatic. However, some patients present with secondary clinical manifestations, which are now grouped under the entity « Monoclonal Gammopathy of Clinical Significance » (MGCS).
Here, we report two rare cases of MGCS: an acquired von Willebrand syndrome (AvWS) and an acquired angioedema (AAE).
The discovery of a decrease in von Willebrand activity (vWF:RCo) or angioedema in a patient over 50 years of age, in the absence of a family history, should prompt a search for a hemopathy and in particular, a monoclonal gammopathy. |
| doi_str_mv | 10.1016/j.revmed.2023.03.005 |
| format | Article |
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Here, we report two rare cases of MGCS: an acquired von Willebrand syndrome (AvWS) and an acquired angioedema (AAE).
The discovery of a decrease in von Willebrand activity (vWF:RCo) or angioedema in a patient over 50 years of age, in the absence of a family history, should prompt a search for a hemopathy and in particular, a monoclonal gammopathy.</description><identifier>EISSN: 1768-3122</identifier><identifier>DOI: 10.1016/j.revmed.2023.03.005</identifier><identifier>PMID: 37005096</identifier><language>eng ; fre</language><publisher>France</publisher><subject>Angioedema ; Humans ; Middle Aged ; Monoclonal Gammopathy of Undetermined Significance - complications ; Monoclonal Gammopathy of Undetermined Significance - diagnosis ; Paraproteinemias - complications ; Paraproteinemias - diagnosis ; von Willebrand Diseases - complications ; von Willebrand Factor</subject><ispartof>La revue de medecine interne, 2023-06, Vol.44 (6), p.307-310</ispartof><rights>Copyright © 2023 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37005096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perlot, Q</creatorcontrib><creatorcontrib>Hermans, C</creatorcontrib><creatorcontrib>Vekemans, M-C</creatorcontrib><title>Rare manifestations of monoclonal gammopathies: About two clinical cases and literature review</title><title>La revue de medecine interne</title><addtitle>Rev Med Interne</addtitle><description>Monoclonal gammopathies are common over the age of 50. Patients are usually asymptomatic. However, some patients present with secondary clinical manifestations, which are now grouped under the entity « Monoclonal Gammopathy of Clinical Significance » (MGCS).
Here, we report two rare cases of MGCS: an acquired von Willebrand syndrome (AvWS) and an acquired angioedema (AAE).
The discovery of a decrease in von Willebrand activity (vWF:RCo) or angioedema in a patient over 50 years of age, in the absence of a family history, should prompt a search for a hemopathy and in particular, a monoclonal gammopathy.</description><subject>Angioedema</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Monoclonal Gammopathy of Undetermined Significance - complications</subject><subject>Monoclonal Gammopathy of Undetermined Significance - diagnosis</subject><subject>Paraproteinemias - complications</subject><subject>Paraproteinemias - diagnosis</subject><subject>von Willebrand Diseases - complications</subject><subject>von Willebrand Factor</subject><issn>1768-3122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kF9LwzAUxYMgbk6_gUgefWnNnzZtfRvDqTAQZM-W2yTVjCapTerw2xtwwoXDhR-Hcw5CN5TklFBxf8gn_W21yhlhPCfpSHmGlrQSdcYpYwt0GcKBEJLo5gIteJUA0oglen-DSWMLzvQ6RIjGu4B9j613Xg7ewYA_wFo_Qvw0OjzgdefniOPRYzkYZ2QCJAQdMDiFBxP1BHFOlimQ0ccrdN7DEPT1SVdov33cb56z3evTy2a9y0ZGacwUg1KpUlHoGkK46IuSaSqbuodeS1nzhksqgVa8IF3FBHAm6vQWqhRNr_gK3f3ZjpP_mlOR1pog9TCA034OLauaQtSClkVCb0_o3KXF2nEyFqaf9n8S_guQx2Sj</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Perlot, Q</creator><creator>Hermans, C</creator><creator>Vekemans, M-C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202306</creationdate><title>Rare manifestations of monoclonal gammopathies: About two clinical cases and literature review</title><author>Perlot, Q ; Hermans, C ; Vekemans, M-C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-d2a5dd5d1ab90036f452e1c98fafecc8393c1ca17340b726a3268a174d569fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>Angioedema</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Monoclonal Gammopathy of Undetermined Significance - complications</topic><topic>Monoclonal Gammopathy of Undetermined Significance - diagnosis</topic><topic>Paraproteinemias - complications</topic><topic>Paraproteinemias - diagnosis</topic><topic>von Willebrand Diseases - complications</topic><topic>von Willebrand Factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perlot, Q</creatorcontrib><creatorcontrib>Hermans, C</creatorcontrib><creatorcontrib>Vekemans, M-C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>La revue de medecine interne</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perlot, Q</au><au>Hermans, C</au><au>Vekemans, M-C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rare manifestations of monoclonal gammopathies: About two clinical cases and literature review</atitle><jtitle>La revue de medecine interne</jtitle><addtitle>Rev Med Interne</addtitle><date>2023-06</date><risdate>2023</risdate><volume>44</volume><issue>6</issue><spage>307</spage><epage>310</epage><pages>307-310</pages><eissn>1768-3122</eissn><abstract>Monoclonal gammopathies are common over the age of 50. Patients are usually asymptomatic. However, some patients present with secondary clinical manifestations, which are now grouped under the entity « Monoclonal Gammopathy of Clinical Significance » (MGCS).
Here, we report two rare cases of MGCS: an acquired von Willebrand syndrome (AvWS) and an acquired angioedema (AAE).
The discovery of a decrease in von Willebrand activity (vWF:RCo) or angioedema in a patient over 50 years of age, in the absence of a family history, should prompt a search for a hemopathy and in particular, a monoclonal gammopathy.</abstract><cop>France</cop><pmid>37005096</pmid><doi>10.1016/j.revmed.2023.03.005</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1768-3122 |
| ispartof | La revue de medecine interne, 2023-06, Vol.44 (6), p.307-310 |
| issn | 1768-3122 |
| language | eng ; fre |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Angioedema Humans Middle Aged Monoclonal Gammopathy of Undetermined Significance - complications Monoclonal Gammopathy of Undetermined Significance - diagnosis Paraproteinemias - complications Paraproteinemias - diagnosis von Willebrand Diseases - complications von Willebrand Factor |
| title | Rare manifestations of monoclonal gammopathies: About two clinical cases and literature review |
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