PGC 1α-Mediates Mitochondrial Damage in the Liver by Inhibiting the Mitochondrial Respiratory Chain as a Non-cholinergic Mechanism of Repeated Low-Level Soman Exposure

This work aimed to assess whether mitochondrial damage in the liver induced by subacute soman exposure is caused by peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) and whether PGC-1α regulates mitochondrial respiratory chain damage. Toxicity mechanism research may provi...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2023-04, Vol.46 (4), p.563-573, Article b22-00633
Hauptverfasser:	Jin, Qian, Zhang, Yi, Cui, Yalan, Shi, Meng, Shi, Jingjing, Zhu, Siqing, Shi, Tong, Zhang, Ruihua, Chen, Xuejun, Zong, Xingxing, Wang, Chen, Li, Liqin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Animal models Animals Electron Transport Electron transport chain Energy metabolism Enzyme-linked immunosorbent assay Enzymes Glutathione Liver Liver - metabolism Male Mitochondria Oxidative stress Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Peroxisome proliferator-activated receptors Protein turnover Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism Soman Soman - metabolism Toxicity Transcription Factors - metabolism Transmission electron microscopy
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