Dichloroacetophenone biphenylsulfone ethers as anticancer pyruvate dehydrogenase kinase inhibitors in non-small cell lung cancer models

Pyruvate dehydrogenase kinase 1 (PDK1) is an important metabolic enzyme which is often overexpressed in many types of cancers, including non-small-cell lung cancers (NSCLC). Targeting PDK1 appears to be an attractive anticancer strategy. Based on a previously reported moderate potent anticancer PDK1...

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Veröffentlicht in:	Chemico-biological interactions 2023-06, Vol.378, p.110467-110467, Article 110467
Hauptverfasser:	Guo, Yizhen, Zhou, Yan, Wu, Puhua, Ran, Maoxin, Xu, Ngai, Shan, Wenying, Sha, Ou, Tam, Kin Yip
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer effect Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Proliferation Dichloroacetophenone Ethers - pharmacology Ethers - therapeutic use Humans Lung Neoplasms - drug therapy Lung Neoplasms - pathology Metabolic alteration Mice NSCLC PDK Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein Serine-Threonine Kinases - metabolism Pyruvate Dehydrogenase Acetyl-Transferring Kinase
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