Undercarboxylated osteocalcin and ibandronate combination ameliorates hindlimb immobilization‐induced muscle wasting

Immobilization leads to muscle wasting and insulin resistance, particularly during ageing. It has been suggested that undercarboxylated osteocalcin (ucOC) improves muscle mass and glucose metabolism. Bisphosphonates, an anti‐osteoporosis treatment, might protect muscle wasting independent of ucOC. W...

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Veröffentlicht in:	The Journal of physiology 2023-05, Vol.601 (10), p.1851-1867
Hauptverfasser:	Lin, Xuzhu, Smith, Cassandra, Moreno‐Asso, Alba, Zarekookandeh, Navabeh, Brennan‐Speranza, Tara C., Duque, Gustavo, Hayes, Alan, Levinger, Itamar
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging AKT protein Animals Biopsy Bisphosphonates Body weight Extracellular signal-regulated kinase Glucose Glucose - metabolism Glucose tolerance hindlimb immobilization Hindlimb Suspension Humans Ibandronic acid Ibandronic Acid - metabolism Immobilization Insulin - metabolism Insulin Resistance Limbs Metabolism Mice Mice, Inbred C57BL muscle wasting Muscle, Skeletal - metabolism Muscles Muscular Atrophy - drug therapy Muscular Atrophy - etiology Muscular Atrophy - prevention & control Myotubes Osteocalcin Osteocalcin - metabolism Osteocalcin - pharmacology Osteoporosis Phosphorylation Proteins Proto-Oncogene Proteins c-akt - metabolism Quadriceps muscle Signal transduction Skeletal muscle TOR protein undercarboxylated osteocalcin
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