MY‐1‐Loaded Nano‐Hydroxyapatite Accelerated Bone Regeneration by Increasing Type III Collagen Deposition in Early‐Stage ECM via a Hsp47‐Dependent Mechanism
The extracellular matrix (ECM) plays a crucial part in regulating stem cell function through its distinctive mechanical and chemical effect. Therefore, it is worth studying how to activate the driving force of osteoblast cells by dynamic changing of ECM and accelerate the bone regeneration. In this...
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| Veröffentlicht in: | Advanced healthcare materials 2023-08, Vol.12 (20), p.e2300332-n/a |
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| creator | Yanli, Zhang Jiayao, Mo Chunqing, Zheng Yuting, Zeng Zhiyan, Zhou Yulin, Zhang Minghan, Li Longquan, Shao Dehong, Yang Wenjuan, Yan |
| description | The extracellular matrix (ECM) plays a crucial part in regulating stem cell function through its distinctive mechanical and chemical effect. Therefore, it is worth studying how to activate the driving force of osteoblast cells by dynamic changing of ECM and accelerate the bone regeneration. In this research, a novel peptide MY‐1 is designed and synthesized. To achieve its sustained releasing, the nano‐hydroxyapatite (nHA) is chosen as the carrier of MY‐1 by mixed adsorption. The results reveal that the sustainable releasing of MY‐1 regulates the synthesis and secretion of ECM from rat bone marrow mesenchymal stem cells (rBMSCs), which promotes the cell migration and osteogenic differentiation in the early stage of bone regeneration. Further analyses demonstrate that MY‐1 increases the expression and nuclear translocation of β‐catenin, and then upregulates the level of heat shock protein 47 (Hsp47), thereby accelerating the synthesis and secretion of type III collagen (Col III) at the early stage. Finally, the promoted rapid transformation of Col III to Col I at late stage benefits the bone regeneration. Hence, this study can provide a theoretical basis for the local application of MY‐1 in bone regeneration.
The peptide MY‐1‐loaded nHA can extend the MY‐1 releasing period in the local bone defect. Then, MY‐1 is endocytosed by parathyroid hormone 1 receptor (PTH1R) and induces the upregulation and nuclear translocation of β‐catenin, thereby promoting the expression of Hsp47 and accelerating the synthesis and secretion of collagen at early stage, thus promoting the early osteogenesis and bone regeneration. |
| doi_str_mv | 10.1002/adhm.202300332 |
| format | Article |
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The peptide MY‐1‐loaded nHA can extend the MY‐1 releasing period in the local bone defect. Then, MY‐1 is endocytosed by parathyroid hormone 1 receptor (PTH1R) and induces the upregulation and nuclear translocation of β‐catenin, thereby promoting the expression of Hsp47 and accelerating the synthesis and secretion of collagen at early stage, thus promoting the early osteogenesis and bone regeneration.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202300332</identifier><identifier>PMID: 36999955</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; Biomedical materials ; Bone growth ; Bone marrow ; Bone Regeneration ; Cell Differentiation ; Cell migration ; Collagen ; Collagen (type III) ; Collagen Type III - metabolism ; Differentiation (biology) ; Durapatite - pharmacology ; Extracellular matrix ; Extracellular Matrix - metabolism ; Heat shock proteins ; Hsp47 ; HSP47 Heat-Shock Proteins - metabolism ; Hydroxyapatite ; Mechanical properties ; Mesenchymal stem cells ; nano‐hydroxyapatite ; Nuclear transport ; Osteogenesis ; Rats ; Regeneration ; Regeneration (physiology) ; Secretion ; short peptide MY‐1 ; Stem cells ; Synthesis ; Tissue Scaffolds</subject><ispartof>Advanced healthcare materials, 2023-08, Vol.12 (20), p.e2300332-n/a</ispartof><rights>2023 Wiley‐VCH GmbH</rights><rights>2023 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3732-59096acb59a442072e9fe8cf62d271419eb1a4fb284a364f6e7f91f3fc087f503</citedby><cites>FETCH-LOGICAL-c3732-59096acb59a442072e9fe8cf62d271419eb1a4fb284a364f6e7f91f3fc087f503</cites><orcidid>0000-0002-5761-5423 ; 0000-0003-0237-0868</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.202300332$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.202300332$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36999955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yanli, Zhang</creatorcontrib><creatorcontrib>Jiayao, Mo</creatorcontrib><creatorcontrib>Chunqing, Zheng</creatorcontrib><creatorcontrib>Yuting, Zeng</creatorcontrib><creatorcontrib>Zhiyan, Zhou</creatorcontrib><creatorcontrib>Yulin, Zhang</creatorcontrib><creatorcontrib>Minghan, Li</creatorcontrib><creatorcontrib>Longquan, Shao</creatorcontrib><creatorcontrib>Dehong, Yang</creatorcontrib><creatorcontrib>Wenjuan, Yan</creatorcontrib><title>MY‐1‐Loaded Nano‐Hydroxyapatite Accelerated Bone Regeneration by Increasing Type III Collagen Deposition in Early‐Stage ECM via a Hsp47‐Dependent Mechanism</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>The extracellular matrix (ECM) plays a crucial part in regulating stem cell function through its distinctive mechanical and chemical effect. Therefore, it is worth studying how to activate the driving force of osteoblast cells by dynamic changing of ECM and accelerate the bone regeneration. In this research, a novel peptide MY‐1 is designed and synthesized. To achieve its sustained releasing, the nano‐hydroxyapatite (nHA) is chosen as the carrier of MY‐1 by mixed adsorption. The results reveal that the sustainable releasing of MY‐1 regulates the synthesis and secretion of ECM from rat bone marrow mesenchymal stem cells (rBMSCs), which promotes the cell migration and osteogenic differentiation in the early stage of bone regeneration. Further analyses demonstrate that MY‐1 increases the expression and nuclear translocation of β‐catenin, and then upregulates the level of heat shock protein 47 (Hsp47), thereby accelerating the synthesis and secretion of type III collagen (Col III) at the early stage. Finally, the promoted rapid transformation of Col III to Col I at late stage benefits the bone regeneration. Hence, this study can provide a theoretical basis for the local application of MY‐1 in bone regeneration.
The peptide MY‐1‐loaded nHA can extend the MY‐1 releasing period in the local bone defect. Then, MY‐1 is endocytosed by parathyroid hormone 1 receptor (PTH1R) and induces the upregulation and nuclear translocation of β‐catenin, thereby promoting the expression of Hsp47 and accelerating the synthesis and secretion of collagen at early stage, thus promoting the early osteogenesis and bone regeneration.</description><subject>Animals</subject><subject>Biomedical materials</subject><subject>Bone growth</subject><subject>Bone marrow</subject><subject>Bone Regeneration</subject><subject>Cell Differentiation</subject><subject>Cell migration</subject><subject>Collagen</subject><subject>Collagen (type III)</subject><subject>Collagen Type III - metabolism</subject><subject>Differentiation (biology)</subject><subject>Durapatite - pharmacology</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - metabolism</subject><subject>Heat shock proteins</subject><subject>Hsp47</subject><subject>HSP47 Heat-Shock Proteins - metabolism</subject><subject>Hydroxyapatite</subject><subject>Mechanical properties</subject><subject>Mesenchymal stem cells</subject><subject>nano‐hydroxyapatite</subject><subject>Nuclear transport</subject><subject>Osteogenesis</subject><subject>Rats</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Secretion</subject><subject>short peptide MY‐1</subject><subject>Stem cells</subject><subject>Synthesis</subject><subject>Tissue Scaffolds</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxiNERavSK0dkiQuX3fpfkvVx2S5spN0iQTlwiibJuHWV2MHOFnLrI_QleDGepF62LBIXRhrZM_7NZ1tfkrxidMoo5efQ3HRTTrmgVAj-LDnhTPEJz1L1_LCX9Dg5C-GWxshSls3Yi-RYZCpGmp4kPzdff90_sJhrBw025BKsi9VqbLz7MUIPgxmQzOsaW_QwROKds0g-4TXaXcM4S6qRFLb2CMHYa3I19kiKoiAL17YQMXKBvQvmN2osWYJvx3jF5yEekuViQ-4MECCr0Ms89iONtkE7kA3WN2BN6F4mRxragGdP62ny5f3yarGarD9-KBbz9aQWueCTVFGVQV2lCqTkNOeoNM5qnfGG50wyhRUDqSs-kyAyqTPMtWJa6JrOcp1ScZq83ev23n3bYhjKzoT48xYsum0oea6EUkxwGdE3_6C3buttfF0Z5XPOZC5UpKZ7qvYuBI-67L3pwI8lo-XOw3LnYXnwMA68fpLdVh02B_yPYxFQe-C7aXH8j1w5v1ht_oo_AoUtrKA</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Yanli, Zhang</creator><creator>Jiayao, Mo</creator><creator>Chunqing, Zheng</creator><creator>Yuting, Zeng</creator><creator>Zhiyan, Zhou</creator><creator>Yulin, Zhang</creator><creator>Minghan, Li</creator><creator>Longquan, Shao</creator><creator>Dehong, Yang</creator><creator>Wenjuan, Yan</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5761-5423</orcidid><orcidid>https://orcid.org/0000-0003-0237-0868</orcidid></search><sort><creationdate>20230801</creationdate><title>MY‐1‐Loaded Nano‐Hydroxyapatite Accelerated Bone Regeneration by Increasing Type III Collagen Deposition in Early‐Stage ECM via a Hsp47‐Dependent Mechanism</title><author>Yanli, Zhang ; 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Therefore, it is worth studying how to activate the driving force of osteoblast cells by dynamic changing of ECM and accelerate the bone regeneration. In this research, a novel peptide MY‐1 is designed and synthesized. To achieve its sustained releasing, the nano‐hydroxyapatite (nHA) is chosen as the carrier of MY‐1 by mixed adsorption. The results reveal that the sustainable releasing of MY‐1 regulates the synthesis and secretion of ECM from rat bone marrow mesenchymal stem cells (rBMSCs), which promotes the cell migration and osteogenic differentiation in the early stage of bone regeneration. Further analyses demonstrate that MY‐1 increases the expression and nuclear translocation of β‐catenin, and then upregulates the level of heat shock protein 47 (Hsp47), thereby accelerating the synthesis and secretion of type III collagen (Col III) at the early stage. Finally, the promoted rapid transformation of Col III to Col I at late stage benefits the bone regeneration. Hence, this study can provide a theoretical basis for the local application of MY‐1 in bone regeneration.
The peptide MY‐1‐loaded nHA can extend the MY‐1 releasing period in the local bone defect. Then, MY‐1 is endocytosed by parathyroid hormone 1 receptor (PTH1R) and induces the upregulation and nuclear translocation of β‐catenin, thereby promoting the expression of Hsp47 and accelerating the synthesis and secretion of collagen at early stage, thus promoting the early osteogenesis and bone regeneration.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36999955</pmid><doi>10.1002/adhm.202300332</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-5761-5423</orcidid><orcidid>https://orcid.org/0000-0003-0237-0868</orcidid></addata></record> |
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| subjects | Animals Biomedical materials Bone growth Bone marrow Bone Regeneration Cell Differentiation Cell migration Collagen Collagen (type III) Collagen Type III - metabolism Differentiation (biology) Durapatite - pharmacology Extracellular matrix Extracellular Matrix - metabolism Heat shock proteins Hsp47 HSP47 Heat-Shock Proteins - metabolism Hydroxyapatite Mechanical properties Mesenchymal stem cells nano‐hydroxyapatite Nuclear transport Osteogenesis Rats Regeneration Regeneration (physiology) Secretion short peptide MY‐1 Stem cells Synthesis Tissue Scaffolds |
| title | MY‐1‐Loaded Nano‐Hydroxyapatite Accelerated Bone Regeneration by Increasing Type III Collagen Deposition in Early‐Stage ECM via a Hsp47‐Dependent Mechanism |
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