Metabolomic analysis of the inhibitory effect of phthalates and bisphenol A on the antioxidant activity of vitamin D in human samples using liquid chromatography–mass spectrometry

•Endogenous metabolites in human plasma were successfully detected using UHPLC-QTOF/MS.•Plasma levels of lysoPC 18:0 and PAF C16 were elevated in subjects with high exposure to phthalates and BPA.•We found that phthalates and BPA reduced vitamin D activity in the antioxidant system. Vitamin D is imp...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2023-04, Vol.1221, p.123687-123687, Article 123687
Hauptverfasser:	Lee, Jae Hwa, Gwon, Mi-Ri, Park, Ji Seo, Lee, Hae Won, Lee, Duk-Hee, Yoon, Young-Ran, Seong, Sook Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Benzhydryl Compounds Bisphenol A Chromatography, Liquid Humans Mass Spectrometry Oxidative stress conditions Phthalates Phthalic Acids UHPLC-QTOF/MS Untargeted metabolomics Vitamin D Vitamin D deficiency Vitamins
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