Dissemination of NDM-producing bacteria in Southern Brazil
The dissemination of NDM-1 carbapenemases (New Delhi Metallo-β-lactamase) is a global public health problem, mainly in developing countries. The aim of this study was to characterize the spread of NDM-producing bacteria in the Southern Brazilian states analyzing epidemiological, molecular, and antim...
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| Veröffentlicht in: | Diagnostic microbiology and infectious disease 2023-06, Vol.106 (2), p.115930-115930, Article 115930 |
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| creator | Arend, Lavinia N.V.S. Bergamo, Ricardo Rocha, Fabiano B. Bail, Larissa Ito, Carmen Baura, Valter A. Balsanelli, Eduardo Pothier, Joël F. Rezzonico, Fabio Pilonetto, Marcelo Smits, Theo H.M. Tuon, Felipe Francisco |
| description | The dissemination of NDM-1 carbapenemases (New Delhi Metallo-β-lactamase) is a global public health problem, mainly in developing countries. The aim of this study was to characterize the spread of NDM-producing bacteria in the Southern Brazilian states analyzing epidemiological, molecular, and antimicrobial susceptibility aspects.
A total of 10,684 carbapenem-resistant isolates of Enterobacterales, Pseudomonas spp. and Acinetobacter spp. obtained from several hospitals in eight cities in Southern Brazil were screened, and 486 NDM-producing bacteria were selected.
The incidence varied from 0.5 to 77 cases/100.000 habitants. ST11, ST15, ST340 and ST674 were the most common in K. pneumoniae. A total of 5 plasmids were identified in one K. pneumoniae strain: Col440I, Col440II, IncFIA(HI1), IncFIB(K), IncFIB(pQil)/ IncFII(K), and IncR.
The number of patients with NDM-producing bacteria has increased in Southern Brazil, whose gene is present in different plasmids, explaining the expansion of this enzyme. |
| doi_str_mv | 10.1016/j.diagmicrobio.2023.115930 |
| format | Article |
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A total of 10,684 carbapenem-resistant isolates of Enterobacterales, Pseudomonas spp. and Acinetobacter spp. obtained from several hospitals in eight cities in Southern Brazil were screened, and 486 NDM-producing bacteria were selected.
The incidence varied from 0.5 to 77 cases/100.000 habitants. ST11, ST15, ST340 and ST674 were the most common in K. pneumoniae. A total of 5 plasmids were identified in one K. pneumoniae strain: Col440I, Col440II, IncFIA(HI1), IncFIB(K), IncFIB(pQil)/ IncFII(K), and IncR.
The number of patients with NDM-producing bacteria has increased in Southern Brazil, whose gene is present in different plasmids, explaining the expansion of this enzyme.</description><identifier>ISSN: 0732-8893</identifier><identifier>EISSN: 1879-0070</identifier><identifier>DOI: 10.1016/j.diagmicrobio.2023.115930</identifier><identifier>PMID: 37001228</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antimicrobial resistance ; beta-Lactamases - genetics ; Brazil - epidemiology ; Carbapenemase ; Carbapenems ; Drug Resistance, Multiple, Bacterial - genetics ; Enterobacterales ; Humans ; Klebsiella Infections - microbiology ; Klebsiella pneumoniae ; Klebsiella pneumoniae - genetics ; Microbial Sensitivity Tests ; Plasmids</subject><ispartof>Diagnostic microbiology and infectious disease, 2023-06, Vol.106 (2), p.115930-115930, Article 115930</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-3c92d120fa1975fd76458ce53174b541168a195c93c20945dd5131c42b3b54593</citedby><cites>FETCH-LOGICAL-c380t-3c92d120fa1975fd76458ce53174b541168a195c93c20945dd5131c42b3b54593</cites><orcidid>0000-0003-3471-1786</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diagmicrobio.2023.115930$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37001228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arend, Lavinia N.V.S.</creatorcontrib><creatorcontrib>Bergamo, Ricardo</creatorcontrib><creatorcontrib>Rocha, Fabiano B.</creatorcontrib><creatorcontrib>Bail, Larissa</creatorcontrib><creatorcontrib>Ito, Carmen</creatorcontrib><creatorcontrib>Baura, Valter A.</creatorcontrib><creatorcontrib>Balsanelli, Eduardo</creatorcontrib><creatorcontrib>Pothier, Joël F.</creatorcontrib><creatorcontrib>Rezzonico, Fabio</creatorcontrib><creatorcontrib>Pilonetto, Marcelo</creatorcontrib><creatorcontrib>Smits, Theo H.M.</creatorcontrib><creatorcontrib>Tuon, Felipe Francisco</creatorcontrib><title>Dissemination of NDM-producing bacteria in Southern Brazil</title><title>Diagnostic microbiology and infectious disease</title><addtitle>Diagn Microbiol Infect Dis</addtitle><description>The dissemination of NDM-1 carbapenemases (New Delhi Metallo-β-lactamase) is a global public health problem, mainly in developing countries. The aim of this study was to characterize the spread of NDM-producing bacteria in the Southern Brazilian states analyzing epidemiological, molecular, and antimicrobial susceptibility aspects.
A total of 10,684 carbapenem-resistant isolates of Enterobacterales, Pseudomonas spp. and Acinetobacter spp. obtained from several hospitals in eight cities in Southern Brazil were screened, and 486 NDM-producing bacteria were selected.
The incidence varied from 0.5 to 77 cases/100.000 habitants. ST11, ST15, ST340 and ST674 were the most common in K. pneumoniae. A total of 5 plasmids were identified in one K. pneumoniae strain: Col440I, Col440II, IncFIA(HI1), IncFIB(K), IncFIB(pQil)/ IncFII(K), and IncR.
The number of patients with NDM-producing bacteria has increased in Southern Brazil, whose gene is present in different plasmids, explaining the expansion of this enzyme.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antimicrobial resistance</subject><subject>beta-Lactamases - genetics</subject><subject>Brazil - epidemiology</subject><subject>Carbapenemase</subject><subject>Carbapenems</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Enterobacterales</subject><subject>Humans</subject><subject>Klebsiella Infections - microbiology</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - genetics</subject><subject>Microbial Sensitivity Tests</subject><subject>Plasmids</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EoqXwCyhixSbBj7iOu4OWl1RgAawtx3aKqyYudoIEX4-jFMSS1Yx078ydOQCcIZghiKYX60xbuaqt8q60LsMQkwwhygncA2NUMJ5CyOA-GENGcFoUnIzAUQhrCBHmOTwEI8L6HhdjMFvYEExtG9la1ySuSh4XD-nWO90p26ySUqrWeCsT2yTPrmvfjG-SKy-_7OYYHFRyE8zJrk7A6831y_wuXT7d3s8vl6kiBWxTojjWCMNKIs5opdk0p4UylCCWlzRHaFpEhSpOFIY8p1pTRJDKcUmiHL-agPNhb7zqvTOhFbUNymw2sjGuCwIzTjiHOO-ts8Ea0YTgTSW23tbSfwoERc9OrMVfdqJnJwZ2cfh0l9OVtdG_oz-womExGEz89sMaL4KyplFGW29UK7Sz_8n5Bg6ehGQ</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Arend, Lavinia N.V.S.</creator><creator>Bergamo, Ricardo</creator><creator>Rocha, Fabiano B.</creator><creator>Bail, Larissa</creator><creator>Ito, Carmen</creator><creator>Baura, Valter A.</creator><creator>Balsanelli, Eduardo</creator><creator>Pothier, Joël F.</creator><creator>Rezzonico, Fabio</creator><creator>Pilonetto, Marcelo</creator><creator>Smits, Theo H.M.</creator><creator>Tuon, Felipe Francisco</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3471-1786</orcidid></search><sort><creationdate>202306</creationdate><title>Dissemination of NDM-producing bacteria in Southern Brazil</title><author>Arend, Lavinia N.V.S. ; 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The aim of this study was to characterize the spread of NDM-producing bacteria in the Southern Brazilian states analyzing epidemiological, molecular, and antimicrobial susceptibility aspects.
A total of 10,684 carbapenem-resistant isolates of Enterobacterales, Pseudomonas spp. and Acinetobacter spp. obtained from several hospitals in eight cities in Southern Brazil were screened, and 486 NDM-producing bacteria were selected.
The incidence varied from 0.5 to 77 cases/100.000 habitants. ST11, ST15, ST340 and ST674 were the most common in K. pneumoniae. A total of 5 plasmids were identified in one K. pneumoniae strain: Col440I, Col440II, IncFIA(HI1), IncFIB(K), IncFIB(pQil)/ IncFII(K), and IncR.
The number of patients with NDM-producing bacteria has increased in Southern Brazil, whose gene is present in different plasmids, explaining the expansion of this enzyme.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37001228</pmid><doi>10.1016/j.diagmicrobio.2023.115930</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3471-1786</orcidid></addata></record> |
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| subjects | Anti-Bacterial Agents - pharmacology Antimicrobial resistance beta-Lactamases - genetics Brazil - epidemiology Carbapenemase Carbapenems Drug Resistance, Multiple, Bacterial - genetics Enterobacterales Humans Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - genetics Microbial Sensitivity Tests Plasmids |
| title | Dissemination of NDM-producing bacteria in Southern Brazil |
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