Factors affecting in-hospital mortality among pediatric patients with myocarditis treated with mechanical circulatory support
Mechanical circulatory support (MCS) is a common treatment modality for circulatory failure caused by pediatric myocarditis. Despite improvements in treatment strategy, the mortality rate of pediatric patients with myocarditis treated with MCS is still high. Identifying the factors associated with m...
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| Veröffentlicht in: | Journal of cardiology 2023-08, Vol.82 (2), p.108-112 |
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| container_title | Journal of cardiology |
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| creator | Urata, Susumu Michihata, Nobuaki Inuzuka, Ryo Matsui, Hiroki Fushimi, Kiyohide Ishimaru, Miho Kato, Motohiro Yasunaga, Hideo |
| description | Mechanical circulatory support (MCS) is a common treatment modality for circulatory failure caused by pediatric myocarditis. Despite improvements in treatment strategy, the mortality rate of pediatric patients with myocarditis treated with MCS is still high. Identifying the factors associated with mortality among pediatric patients with myocarditis treated with MCS may help reduce the mortality rate.
This retrospective cohort study examined the data of patients aged |
| doi_str_mv | 10.1016/j.jjcc.2023.03.009 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2793988666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0914508723000631</els_id><sourcerecordid>2793988666</sourcerecordid><originalsourceid>FETCH-LOGICAL-c331t-3291165bac9b3257e693729007af07023d8fc821dfc77d76be8a1629901716083</originalsourceid><addsrcrecordid>eNp9kD1rHDEQhkVwiM9O_kAKozLNXkaSTx_gxhg7MRjSJLXQzWpzWnZXa0lrc0X-e3TcJaVhYIp55xnmIeQzgzUDJr_2675HXHPgYg21wLwjK6aVbK6V0GdkBYZdNxvQ6pxc5NwDSDBafiDnQhqjAGBF_jw4LDFl6rrOYwnTbxqmZhfzHIob6BhTbaHsqRtjnc2-Da6kgHR2JfipZPoayo6O-4gutaGETEvyrvj2NPC4c1PAysKQcBlcvbaneZnniv5I3nduyP7TqV-SXw_3P---N08_vj3e3T41KAQrjeCGMbnZOjRbwTfKSyMUNwDKdaDq-63uUHPWdqhUq-TWa8ckNwaYYhK0uCRfjtw5xefF52LHkNEPg5t8XLLlygijtZSyRvkxiinmnHxn5xRGl_aWgT1ot709aLcH7RZqgalLVyf-sh19-3_ln-cauDkGfP3yJfhkM1Z9WHWmqt22MbzF_wvB-ZYD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2793988666</pqid></control><display><type>article</type><title>Factors affecting in-hospital mortality among pediatric patients with myocarditis treated with mechanical circulatory support</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Urata, Susumu ; Michihata, Nobuaki ; Inuzuka, Ryo ; Matsui, Hiroki ; Fushimi, Kiyohide ; Ishimaru, Miho ; Kato, Motohiro ; Yasunaga, Hideo</creator><creatorcontrib>Urata, Susumu ; Michihata, Nobuaki ; Inuzuka, Ryo ; Matsui, Hiroki ; Fushimi, Kiyohide ; Ishimaru, Miho ; Kato, Motohiro ; Yasunaga, Hideo</creatorcontrib><description>Mechanical circulatory support (MCS) is a common treatment modality for circulatory failure caused by pediatric myocarditis. Despite improvements in treatment strategy, the mortality rate of pediatric patients with myocarditis treated with MCS is still high. Identifying the factors associated with mortality among pediatric patients with myocarditis treated with MCS may help reduce the mortality rate.
This retrospective cohort study examined the data of patients aged <16 years who were admitted to a hospital between July 2010 and March 2018 for myocarditis; the data were collected from the Diagnosis Procedure Combination database, which is a national inpatient database in Japan.
During the study period, 105 of the 598 patients with myocarditis were treated with MCS. We excluded seven patients who died within 24 h of admission, resulting in 98 eligible patients. The overall in-hospital mortality was 22 %. In-hospital mortality was higher among patients aged <2 years and those who received cardiopulmonary resuscitation (CPR). Multivariable logistic regression analysis showed significantly higher in-hospital mortality among patients aged <2 years old [odds ratio (OR), 6.57; 95 % confidence interval (CI), 1.89–22.87] and those who received CPR (OR, 4.70; 95 % CI, 1.51–14.63; p < 0.01).
The in-hospital mortality of pediatric patients with myocarditis treated with MCS was high, particularly of children younger than 2 years and those who received CPR.
[Display omitted]
•This retrospective study examined the data of pediatric patients with myocarditis.•Data from the Diagnosis Procedure Combination database were examined.•Mortality of pediatric patients with myocarditis treated with mechanical circulatory support (MCS) was 22 %.•Age < 2 years old and need for cardiopulmonary resuscitation were risk factors for death from MCS.</description><identifier>ISSN: 0914-5087</identifier><identifier>EISSN: 1876-4738</identifier><identifier>DOI: 10.1016/j.jjcc.2023.03.009</identifier><identifier>PMID: 36997000</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Cardiopulmonary resuscitation ; Children ; Mechanical circulatory support ; Mortality ; Myocarditis</subject><ispartof>Journal of cardiology, 2023-08, Vol.82 (2), p.108-112</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c331t-3291165bac9b3257e693729007af07023d8fc821dfc77d76be8a1629901716083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0914508723000631$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36997000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Urata, Susumu</creatorcontrib><creatorcontrib>Michihata, Nobuaki</creatorcontrib><creatorcontrib>Inuzuka, Ryo</creatorcontrib><creatorcontrib>Matsui, Hiroki</creatorcontrib><creatorcontrib>Fushimi, Kiyohide</creatorcontrib><creatorcontrib>Ishimaru, Miho</creatorcontrib><creatorcontrib>Kato, Motohiro</creatorcontrib><creatorcontrib>Yasunaga, Hideo</creatorcontrib><title>Factors affecting in-hospital mortality among pediatric patients with myocarditis treated with mechanical circulatory support</title><title>Journal of cardiology</title><addtitle>J Cardiol</addtitle><description>Mechanical circulatory support (MCS) is a common treatment modality for circulatory failure caused by pediatric myocarditis. Despite improvements in treatment strategy, the mortality rate of pediatric patients with myocarditis treated with MCS is still high. Identifying the factors associated with mortality among pediatric patients with myocarditis treated with MCS may help reduce the mortality rate.
This retrospective cohort study examined the data of patients aged <16 years who were admitted to a hospital between July 2010 and March 2018 for myocarditis; the data were collected from the Diagnosis Procedure Combination database, which is a national inpatient database in Japan.
During the study period, 105 of the 598 patients with myocarditis were treated with MCS. We excluded seven patients who died within 24 h of admission, resulting in 98 eligible patients. The overall in-hospital mortality was 22 %. In-hospital mortality was higher among patients aged <2 years and those who received cardiopulmonary resuscitation (CPR). Multivariable logistic regression analysis showed significantly higher in-hospital mortality among patients aged <2 years old [odds ratio (OR), 6.57; 95 % confidence interval (CI), 1.89–22.87] and those who received CPR (OR, 4.70; 95 % CI, 1.51–14.63; p < 0.01).
The in-hospital mortality of pediatric patients with myocarditis treated with MCS was high, particularly of children younger than 2 years and those who received CPR.
[Display omitted]
•This retrospective study examined the data of pediatric patients with myocarditis.•Data from the Diagnosis Procedure Combination database were examined.•Mortality of pediatric patients with myocarditis treated with mechanical circulatory support (MCS) was 22 %.•Age < 2 years old and need for cardiopulmonary resuscitation were risk factors for death from MCS.</description><subject>Cardiopulmonary resuscitation</subject><subject>Children</subject><subject>Mechanical circulatory support</subject><subject>Mortality</subject><subject>Myocarditis</subject><issn>0914-5087</issn><issn>1876-4738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kD1rHDEQhkVwiM9O_kAKozLNXkaSTx_gxhg7MRjSJLXQzWpzWnZXa0lrc0X-e3TcJaVhYIp55xnmIeQzgzUDJr_2675HXHPgYg21wLwjK6aVbK6V0GdkBYZdNxvQ6pxc5NwDSDBafiDnQhqjAGBF_jw4LDFl6rrOYwnTbxqmZhfzHIob6BhTbaHsqRtjnc2-Da6kgHR2JfipZPoayo6O-4gutaGETEvyrvj2NPC4c1PAysKQcBlcvbaneZnniv5I3nduyP7TqV-SXw_3P---N08_vj3e3T41KAQrjeCGMbnZOjRbwTfKSyMUNwDKdaDq-63uUHPWdqhUq-TWa8ckNwaYYhK0uCRfjtw5xefF52LHkNEPg5t8XLLlygijtZSyRvkxiinmnHxn5xRGl_aWgT1ot709aLcH7RZqgalLVyf-sh19-3_ln-cauDkGfP3yJfhkM1Z9WHWmqt22MbzF_wvB-ZYD</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Urata, Susumu</creator><creator>Michihata, Nobuaki</creator><creator>Inuzuka, Ryo</creator><creator>Matsui, Hiroki</creator><creator>Fushimi, Kiyohide</creator><creator>Ishimaru, Miho</creator><creator>Kato, Motohiro</creator><creator>Yasunaga, Hideo</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202308</creationdate><title>Factors affecting in-hospital mortality among pediatric patients with myocarditis treated with mechanical circulatory support</title><author>Urata, Susumu ; Michihata, Nobuaki ; Inuzuka, Ryo ; Matsui, Hiroki ; Fushimi, Kiyohide ; Ishimaru, Miho ; Kato, Motohiro ; Yasunaga, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-3291165bac9b3257e693729007af07023d8fc821dfc77d76be8a1629901716083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiopulmonary resuscitation</topic><topic>Children</topic><topic>Mechanical circulatory support</topic><topic>Mortality</topic><topic>Myocarditis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Urata, Susumu</creatorcontrib><creatorcontrib>Michihata, Nobuaki</creatorcontrib><creatorcontrib>Inuzuka, Ryo</creatorcontrib><creatorcontrib>Matsui, Hiroki</creatorcontrib><creatorcontrib>Fushimi, Kiyohide</creatorcontrib><creatorcontrib>Ishimaru, Miho</creatorcontrib><creatorcontrib>Kato, Motohiro</creatorcontrib><creatorcontrib>Yasunaga, Hideo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Urata, Susumu</au><au>Michihata, Nobuaki</au><au>Inuzuka, Ryo</au><au>Matsui, Hiroki</au><au>Fushimi, Kiyohide</au><au>Ishimaru, Miho</au><au>Kato, Motohiro</au><au>Yasunaga, Hideo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors affecting in-hospital mortality among pediatric patients with myocarditis treated with mechanical circulatory support</atitle><jtitle>Journal of cardiology</jtitle><addtitle>J Cardiol</addtitle><date>2023-08</date><risdate>2023</risdate><volume>82</volume><issue>2</issue><spage>108</spage><epage>112</epage><pages>108-112</pages><issn>0914-5087</issn><eissn>1876-4738</eissn><abstract>Mechanical circulatory support (MCS) is a common treatment modality for circulatory failure caused by pediatric myocarditis. Despite improvements in treatment strategy, the mortality rate of pediatric patients with myocarditis treated with MCS is still high. Identifying the factors associated with mortality among pediatric patients with myocarditis treated with MCS may help reduce the mortality rate.
This retrospective cohort study examined the data of patients aged <16 years who were admitted to a hospital between July 2010 and March 2018 for myocarditis; the data were collected from the Diagnosis Procedure Combination database, which is a national inpatient database in Japan.
During the study period, 105 of the 598 patients with myocarditis were treated with MCS. We excluded seven patients who died within 24 h of admission, resulting in 98 eligible patients. The overall in-hospital mortality was 22 %. In-hospital mortality was higher among patients aged <2 years and those who received cardiopulmonary resuscitation (CPR). Multivariable logistic regression analysis showed significantly higher in-hospital mortality among patients aged <2 years old [odds ratio (OR), 6.57; 95 % confidence interval (CI), 1.89–22.87] and those who received CPR (OR, 4.70; 95 % CI, 1.51–14.63; p < 0.01).
The in-hospital mortality of pediatric patients with myocarditis treated with MCS was high, particularly of children younger than 2 years and those who received CPR.
[Display omitted]
•This retrospective study examined the data of pediatric patients with myocarditis.•Data from the Diagnosis Procedure Combination database were examined.•Mortality of pediatric patients with myocarditis treated with mechanical circulatory support (MCS) was 22 %.•Age < 2 years old and need for cardiopulmonary resuscitation were risk factors for death from MCS.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>36997000</pmid><doi>10.1016/j.jjcc.2023.03.009</doi><tpages>5</tpages></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Cardiopulmonary resuscitation Children Mechanical circulatory support Mortality Myocarditis |
| title | Factors affecting in-hospital mortality among pediatric patients with myocarditis treated with mechanical circulatory support |
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