Advances in receptor chromatography for drug discovery and drug–receptor interaction studies
[Display omitted] •This review summarizes the immobilization methods of receptor chromatography.•The applications of receptor chromatography are discussed.•Future challenges of receptor chromatography and solutions have been expounded. Receptor chromatography involves high-throughput separation and...
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| Veröffentlicht in: | Drug discovery today 2023-06, Vol.28 (6), p.103576-103576, Article 103576 |
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| container_end_page | 103576 |
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| container_issue | 6 |
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| container_title | Drug discovery today |
| container_volume | 28 |
| creator | Fu, Jia Qin, Wei Cao, Lu-Qi Chen, Zhe-Sheng Cao, Hui-Ling |
| description | [Display omitted]
•This review summarizes the immobilization methods of receptor chromatography.•The applications of receptor chromatography are discussed.•Future challenges of receptor chromatography and solutions have been expounded.
Receptor chromatography involves high-throughput separation and accurate drug screening based on specific drug–receptor recognition and affinity, which has been widely used to screen active compounds in complex samples. This review summarizes the immobilization methods for receptors from three aspects: random covalent immobilization methods, site-specific covalent immobilization methods and dual-target receptor chromatography. Meanwhile, it focuses on its applications from three angles: screening active compounds in natural products, in natural-product-derived DNA-encoded compound libraries and drug–receptor interactions. This review provides new insights for the design and application of receptor chromatography, high-throughput and accurate drug screening, drug–receptor interactions and more. |
| doi_str_mv | 10.1016/j.drudis.2023.103576 |
| format | Article |
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•This review summarizes the immobilization methods of receptor chromatography.•The applications of receptor chromatography are discussed.•Future challenges of receptor chromatography and solutions have been expounded.
Receptor chromatography involves high-throughput separation and accurate drug screening based on specific drug–receptor recognition and affinity, which has been widely used to screen active compounds in complex samples. This review summarizes the immobilization methods for receptors from three aspects: random covalent immobilization methods, site-specific covalent immobilization methods and dual-target receptor chromatography. Meanwhile, it focuses on its applications from three angles: screening active compounds in natural products, in natural-product-derived DNA-encoded compound libraries and drug–receptor interactions. This review provides new insights for the design and application of receptor chromatography, high-throughput and accurate drug screening, drug–receptor interactions and more.</description><identifier>ISSN: 1359-6446</identifier><identifier>EISSN: 1878-5832</identifier><identifier>DOI: 10.1016/j.drudis.2023.103576</identifier><identifier>PMID: 37003514</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Biological Products - chemistry ; Chromatography ; Drug Discovery - methods ; Drug Evaluation, Preclinical - methods ; drug screening ; drug–receptor interactions ; Gene Library ; natural product ; protein immobilization ; Receptor chromatography</subject><ispartof>Drug discovery today, 2023-06, Vol.28 (6), p.103576-103576, Article 103576</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-db64565226ebe73a628b2934354f894ff783b3485e94bb7d78758acdf275b6943</citedby><cites>FETCH-LOGICAL-c362t-db64565226ebe73a628b2934354f894ff783b3485e94bb7d78758acdf275b6943</cites><orcidid>0000-0002-8289-097X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1359644623000922$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37003514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Jia</creatorcontrib><creatorcontrib>Qin, Wei</creatorcontrib><creatorcontrib>Cao, Lu-Qi</creatorcontrib><creatorcontrib>Chen, Zhe-Sheng</creatorcontrib><creatorcontrib>Cao, Hui-Ling</creatorcontrib><title>Advances in receptor chromatography for drug discovery and drug–receptor interaction studies</title><title>Drug discovery today</title><addtitle>Drug Discov Today</addtitle><description>[Display omitted]
•This review summarizes the immobilization methods of receptor chromatography.•The applications of receptor chromatography are discussed.•Future challenges of receptor chromatography and solutions have been expounded.
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•This review summarizes the immobilization methods of receptor chromatography.•The applications of receptor chromatography are discussed.•Future challenges of receptor chromatography and solutions have been expounded.
Receptor chromatography involves high-throughput separation and accurate drug screening based on specific drug–receptor recognition and affinity, which has been widely used to screen active compounds in complex samples. This review summarizes the immobilization methods for receptors from three aspects: random covalent immobilization methods, site-specific covalent immobilization methods and dual-target receptor chromatography. Meanwhile, it focuses on its applications from three angles: screening active compounds in natural products, in natural-product-derived DNA-encoded compound libraries and drug–receptor interactions. This review provides new insights for the design and application of receptor chromatography, high-throughput and accurate drug screening, drug–receptor interactions and more.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37003514</pmid><doi>10.1016/j.drudis.2023.103576</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-8289-097X</orcidid></addata></record> |
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| ispartof | Drug discovery today, 2023-06, Vol.28 (6), p.103576-103576, Article 103576 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological Products - chemistry Chromatography Drug Discovery - methods Drug Evaluation, Preclinical - methods drug screening drug–receptor interactions Gene Library natural product protein immobilization Receptor chromatography |
| title | Advances in receptor chromatography for drug discovery and drug–receptor interaction studies |
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