Cu-Catalyzed Regioselective C–H Amination of 2H‑Indazoles for the Synthesis of Indazole-Containing Indazol-3(2H)‑ones

Cu-Catalyzed Regioselective C–H Amination of 2H‑Indazoles for the Synthesis of Indazole-Containing Indazol-3(2H)‑ones

A copper-catalyzed C3 amination of 2H-indazoles with 2H-indazoles and indazol-3­(2H)-ones under mild conditions was developed. A series of indazole-containing indazol-3­(2H)-one derivatives were produced in moderate to excellent yields. The mechanistic studies suggest that the reactions probably pro...

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Veröffentlicht in:Journal of organic chemistry 2023-05, Vol.88 (9), p.5731-5744
Hauptverfasser: Zhang, Lina, Yan, Hang, Fan, Yueyue, Luo, Xiande, Pan, Yingqiao, Liu, Yishu, Cai, Yuepiao, Xia, Qinqin
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container_end_page 5744
container_issue 9
container_start_page 5731
container_title Journal of organic chemistry
container_volume 88
creator Zhang, Lina
Yan, Hang
Fan, Yueyue
Luo, Xiande
Pan, Yingqiao
Liu, Yishu
Cai, Yuepiao
Xia, Qinqin
description A copper-catalyzed C3 amination of 2H-indazoles with 2H-indazoles and indazol-3­(2H)-ones under mild conditions was developed. A series of indazole-containing indazol-3­(2H)-one derivatives were produced in moderate to excellent yields. The mechanistic studies suggest that the reactions probably proceed through a radical pathway.
doi_str_mv 10.1021/acs.joc.3c00187
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title Cu-Catalyzed Regioselective C–H Amination of 2H‑Indazoles for the Synthesis of Indazole-Containing Indazol-3(2H)‑ones
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