A potent and selective CXCR2 antagonist improves neuroimmune dysregulation through the inhibition of NF-κB and notch inflammatory signaling in the BTBR mouse model of autism

Autism comprises a broad range of neurodevelopmental disorders characterized by social communication deficits and repetitive and stereotyped behaviors. Chemokine receptor CXCR2 is expressed on neurons and is upregulated in neurological disorders. BTBR T+ Itpr3tf/J (BTBR) mice, a model for autism tha...

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Veröffentlicht in:	Journal of neuroimmunology 2023-04, Vol.377, p.578069-578069, Article 578069
Hauptverfasser:	Alomar, Hatun A., Ansari, Mushtaq A., Nadeem, Ahmed, Attia, Sabry M., Bakheet, Saleh A., Al-Mazroua, Haneen A., Hussein, Marwa H., Alqarni, Saleh A., Ahmad, Sheikh F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Autism Autistic Disorder - drug therapy BTBR T+ Itpr3tf/J mice CXCR2 antagonist Disease Models, Animal Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use Inflammatory mediators Interleukin-2 Interleukin-6 Mice Mice, Inbred C57BL Mice, Inbred Strains NF-kappa B - metabolism NF-κB/notch signaling RNA, Messenger Transforming Growth Factor beta1
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