An oncolytic herpes simplex virus type 1 strain expressing a single-chain variable region antibody fragment against PD-1 and a PI3K inhibitor synergize to elicit antitumor immunity in ovarian cancer

Due to recurrence and resistance to chemotherapy, the current standard therapeutics are not fully effective against ovarian cancer. Therefore, we aimed to find an effective approach to improve the prognosis and therapy of ovarian cancer. NG34ScFvPD-1 is a modified oncolytic herpes simplex virus NG34...

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Veröffentlicht in:	Archives of virology 2023-04, Vol.168 (4), p.128-128, Article 128
Hauptverfasser:	Huang, Shanying, Hu, Haiyan, Tang, Guoling, Liu, Kai, Luo, Zhihua, Zeng, Weiwei
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Apoptosis Biomedical and Life Sciences Biomedicine Caspase Cell death Cell Line, Tumor Chemotherapy Cytotoxicity Enzyme-linked immunosorbent assay Female Herpes simplex Herpes viruses Herpesvirus 1, Human Humans Immunity Infectious Diseases Kinases Medical Microbiology Medical prognosis Mice Oncolysis Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Original Article Ovarian cancer Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy PD-1 protein Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Programmed Cell Death 1 Receptor Signal transduction Single-Chain Antibodies - genetics Synergism Variable region Virology
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