The action of phosphodiesterase-5 inhibitors on β-amyloid pathology and cognition in experimental Alzheimer's disease: A systematic review

Alzheimer's disease (AD) is the most frequent cause of dementia worldwide. The etiology of AD is partially explained by the deposition of β-amyloid in the brain. Despite extensive research on the pathogenesis of AD, the current treatments are ineffective. Here, we systematically reviewed studie...

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Veröffentlicht in:	Life sciences (1973) 2023-05, Vol.320, p.121570-121570, Article 121570
Hauptverfasser:	Justo, Alberto Fernando Oliveira, Toscano, Eliana Cristina de Brito, Farias-Itao, Daniela Souza, Suemoto, Claudia Kimie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides Animals Beta-amyloid Cognition Cyclic Nucleotide Phosphodiesterases, Type 5 Female Male Phosphodiesterase 5 inhibitors Phosphodiesterase 5 Inhibitors - pharmacology Phosphodiesterase 5 Inhibitors - therapeutic use
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