Human milk-derived fortifiers are linked with feed extension due to Hypoglycemia in infants <1250 g or <30 weeks: a matched retrospective chart review
Objective To investigate differences in hypoglycemia and extended feed prescriptions among premature infants provided bovine-derived human milk fortifiers (Bov-fort) with mother’s milk or formula vs human milk-derived human milk fortifiers (HM-fort) with mother’s milk or donor human milk. Study desi...
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| Veröffentlicht in: | Journal of perinatology 2023-05, Vol.43 (5), p.624-628 |
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| container_title | Journal of perinatology |
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| creator | Ackley, Danielle Wang, Hongyue D’Angio, Carl T. Meyers, Jeffrey Young, Bridget E. |
| description | Objective
To investigate differences in hypoglycemia and extended feed prescriptions among premature infants provided bovine-derived human milk fortifiers (Bov-fort) with mother’s milk or formula vs human milk-derived human milk fortifiers (HM-fort) with mother’s milk or donor human milk.
Study design
This was a retrospective chart review (
n
= 98). Infants receiving HM-fort were matched with infants receiving Bov-fort. Blood glucose values and feed orders were retrieved from the electronic medical record.
Results
Prevalence of ever having blood glucose |
| doi_str_mv | 10.1038/s41372-023-01654-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2792901850</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2792901850</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-1652ee5832e360d699f8b031dad495d0b35f4c3b81ec4585c1cd0f4325b1e1353</originalsourceid><addsrcrecordid>eNp9kU1uFDEQhS1ERIbABVggS2zYdGK77G43yiaKgEGKxAbWlttdPeNM_wy2O8NkxZYbcD5OEocJILFAsmSr6qtXfnqEvODslDPQZ1FyqETBBBSMl0oWt4_IgsuqLJSS8JgsWCWh0CDLY_I0xmvG7pvVE3IMZV1zLvmC_FjOgx3p4PtN0WLwN9jSbgrJdx5DpDYg7f24ydWdT2vaYX7h14Rj9NNI2xlpmuhyv51W_d7h4C31Yz6dHVOk51wo9vPb9xWdAj0HRneIm_iGWjrY5NZZKmAKU9yiS3kzdWsbUq7deNw9I0ed7SM-f7hPyOd3bz9dLourj-8_XF5cFQ4qlYrsWyAqDQKhZG321emGAW9tK2vVsgZUJx00mqOTSivHXcs6CUI1HDkoOCGvD7rbMH2ZMSYz-Oiw7-2I0xyNqGpRM64Vy-irf9DraQ5j_p0RmvOq0iWDTIkD5bKzGLAz2-AHG_aGM3OfmznkZnJu5ldu5jYPvXyQnpsB2z8jv4PKAByAmFvjCsPf3f-RvQOss6TR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2811778603</pqid></control><display><type>article</type><title>Human milk-derived fortifiers are linked with feed extension due to Hypoglycemia in infants <1250 g or <30 weeks: a matched retrospective chart review</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Ackley, Danielle ; Wang, Hongyue ; D’Angio, Carl T. ; Meyers, Jeffrey ; Young, Bridget E.</creator><creatorcontrib>Ackley, Danielle ; Wang, Hongyue ; D’Angio, Carl T. ; Meyers, Jeffrey ; Young, Bridget E.</creatorcontrib><description>Objective
To investigate differences in hypoglycemia and extended feed prescriptions among premature infants provided bovine-derived human milk fortifiers (Bov-fort) with mother’s milk or formula vs human milk-derived human milk fortifiers (HM-fort) with mother’s milk or donor human milk.
Study design
This was a retrospective chart review (
n
= 98). Infants receiving HM-fort were matched with infants receiving Bov-fort. Blood glucose values and feed orders were retrieved from the electronic medical record.
Results
Prevalence of ever having blood glucose <60 mg/dL was 39.1% in the HM-fort group vs. 23.9% in the Bov-fort group (
p
= 0.09). Blood glucose ≤45 mg/dL occurred in 17.4% of HM-fort vs 4.3% in Bov-fort (
p
= 0.07). Feeds were extended for any reason in 55% of HM-fort vs. 20% of Bov-fort (
p
< 0.01). Feed extension due to hypoglycemia occurred in 24% of HM-fort vs. 0% of Bov-fort (
p
< 0.01).
Conclusion
Predominately HM-based feeds are associated with feed extension due to hypoglycemia. Prospective research is warranted to elucidate underlying mechanisms.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-023-01654-z</identifier><identifier>PMID: 36991141</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/308/409 ; 692/700/1720 ; Animals ; Blood ; Blood Glucose ; Breast milk ; Breastfeeding & lactation ; Cattle ; Charts ; Electronic health records ; Electronic medical records ; Food fortification ; Glucose ; Humans ; Hypoglycemia ; Infant ; Infants ; Medicine ; Medicine & Public Health ; Milk ; Milk, Human ; Pediatric Surgery ; Pediatrics ; Premature babies ; Prospective Studies ; Retrospective Studies</subject><ispartof>Journal of perinatology, 2023-05, Vol.43 (5), p.624-628</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1652ee5832e360d699f8b031dad495d0b35f4c3b81ec4585c1cd0f4325b1e1353</citedby><cites>FETCH-LOGICAL-c375t-1652ee5832e360d699f8b031dad495d0b35f4c3b81ec4585c1cd0f4325b1e1353</cites><orcidid>0000-0002-3257-8179 ; 0000-0001-7461-5938</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41372-023-01654-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41372-023-01654-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36991141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ackley, Danielle</creatorcontrib><creatorcontrib>Wang, Hongyue</creatorcontrib><creatorcontrib>D’Angio, Carl T.</creatorcontrib><creatorcontrib>Meyers, Jeffrey</creatorcontrib><creatorcontrib>Young, Bridget E.</creatorcontrib><title>Human milk-derived fortifiers are linked with feed extension due to Hypoglycemia in infants <1250 g or <30 weeks: a matched retrospective chart review</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
To investigate differences in hypoglycemia and extended feed prescriptions among premature infants provided bovine-derived human milk fortifiers (Bov-fort) with mother’s milk or formula vs human milk-derived human milk fortifiers (HM-fort) with mother’s milk or donor human milk.
Study design
This was a retrospective chart review (
n
= 98). Infants receiving HM-fort were matched with infants receiving Bov-fort. Blood glucose values and feed orders were retrieved from the electronic medical record.
Results
Prevalence of ever having blood glucose <60 mg/dL was 39.1% in the HM-fort group vs. 23.9% in the Bov-fort group (
p
= 0.09). Blood glucose ≤45 mg/dL occurred in 17.4% of HM-fort vs 4.3% in Bov-fort (
p
= 0.07). Feeds were extended for any reason in 55% of HM-fort vs. 20% of Bov-fort (
p
< 0.01). Feed extension due to hypoglycemia occurred in 24% of HM-fort vs. 0% of Bov-fort (
p
< 0.01).
Conclusion
Predominately HM-based feeds are associated with feed extension due to hypoglycemia. Prospective research is warranted to elucidate underlying mechanisms.</description><subject>692/308/409</subject><subject>692/700/1720</subject><subject>Animals</subject><subject>Blood</subject><subject>Blood Glucose</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Cattle</subject><subject>Charts</subject><subject>Electronic health records</subject><subject>Electronic medical records</subject><subject>Food fortification</subject><subject>Glucose</subject><subject>Humans</subject><subject>Hypoglycemia</subject><subject>Infant</subject><subject>Infants</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Milk</subject><subject>Milk, Human</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Premature babies</subject><subject>Prospective Studies</subject><subject>Retrospective 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milk-derived fortifiers are linked with feed extension due to Hypoglycemia in infants <1250 g or <30 weeks: a matched retrospective chart review</title><author>Ackley, Danielle ; Wang, Hongyue ; D’Angio, Carl T. ; Meyers, Jeffrey ; Young, Bridget E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-1652ee5832e360d699f8b031dad495d0b35f4c3b81ec4585c1cd0f4325b1e1353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>692/308/409</topic><topic>692/700/1720</topic><topic>Animals</topic><topic>Blood</topic><topic>Blood Glucose</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>Cattle</topic><topic>Charts</topic><topic>Electronic health records</topic><topic>Electronic medical records</topic><topic>Food fortification</topic><topic>Glucose</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Infant</topic><topic>Infants</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Milk</topic><topic>Milk, Human</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Premature babies</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ackley, Danielle</creatorcontrib><creatorcontrib>Wang, Hongyue</creatorcontrib><creatorcontrib>D’Angio, Carl T.</creatorcontrib><creatorcontrib>Meyers, Jeffrey</creatorcontrib><creatorcontrib>Young, Bridget E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central 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Jeffrey</au><au>Young, Bridget E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human milk-derived fortifiers are linked with feed extension due to Hypoglycemia in infants <1250 g or <30 weeks: a matched retrospective chart review</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>43</volume><issue>5</issue><spage>624</spage><epage>628</epage><pages>624-628</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective
To investigate differences in hypoglycemia and extended feed prescriptions among premature infants provided bovine-derived human milk fortifiers (Bov-fort) with mother’s milk or formula vs human milk-derived human milk fortifiers (HM-fort) with mother’s milk or donor human milk.
Study design
This was a retrospective chart review (
n
= 98). Infants receiving HM-fort were matched with infants receiving Bov-fort. Blood glucose values and feed orders were retrieved from the electronic medical record.
Results
Prevalence of ever having blood glucose <60 mg/dL was 39.1% in the HM-fort group vs. 23.9% in the Bov-fort group (
p
= 0.09). Blood glucose ≤45 mg/dL occurred in 17.4% of HM-fort vs 4.3% in Bov-fort (
p
= 0.07). Feeds were extended for any reason in 55% of HM-fort vs. 20% of Bov-fort (
p
< 0.01). Feed extension due to hypoglycemia occurred in 24% of HM-fort vs. 0% of Bov-fort (
p
< 0.01).
Conclusion
Predominately HM-based feeds are associated with feed extension due to hypoglycemia. Prospective research is warranted to elucidate underlying mechanisms.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>36991141</pmid><doi>10.1038/s41372-023-01654-z</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-3257-8179</orcidid><orcidid>https://orcid.org/0000-0001-7461-5938</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2023-05, Vol.43 (5), p.624-628 |
| issn | 0743-8346 1476-5543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2792901850 |
| source | MEDLINE; SpringerLink Journals |
| subjects | 692/308/409 692/700/1720 Animals Blood Blood Glucose Breast milk Breastfeeding & lactation Cattle Charts Electronic health records Electronic medical records Food fortification Glucose Humans Hypoglycemia Infant Infants Medicine Medicine & Public Health Milk Milk, Human Pediatric Surgery Pediatrics Premature babies Prospective Studies Retrospective Studies |
| title | Human milk-derived fortifiers are linked with feed extension due to Hypoglycemia in infants <1250 g or <30 weeks: a matched retrospective chart review |
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