Natural history of spinal cord metastasis from brain glioblastomas
Background and Objectives Spinal cord metastasis arising from an intracranial glioblastoma is a rare and late event during the natural course of the disease. These pathological entities remain poorly characterized. This study aimed to identify and investigate the timeline, clinical and imaging findi...
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| Veröffentlicht in: | Journal of neuro-oncology 2023-04, Vol.162 (2), p.373-382 |
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| creator | Amelot, Aymeric Terrier, Louis-Marie Cognacq, Gabrielle Jecko, Vincent Marlier, Benoit Seizeur, Romuald Emery, Evelyne Bauchet, Luc Roualdes, Vincent Voirin, Jimmy Joubert, Christophe Mandonnet, Emmanuel Lemnos, Leslie Mathon, Bertrand Le Reste, Pierre-Jean Coca, Andres Petit, Antoine Rigau, Valérie Mokhtari, Karima Rousseau, Audrey Metellus, Philippe Figarella-Branger, Dominique Gauchotte, Guillaume Farah, Kaissar Pallud, Johan Zemmoura, Ilyess |
| description | Background and Objectives
Spinal cord metastasis arising from an intracranial glioblastoma is a rare and late event during the natural course of the disease. These pathological entities remain poorly characterized. This study aimed to identify and investigate the timeline, clinical and imaging findings, and prognostic factors of spinal cord metastasis from a glioblastoma.
Methods
Consecutive histopathological cases of spinal cord metastasis from glioblastomas in adults entered in the French nationwide database between January 2004 and 2016 were screened.
Results
Overall, 14 adult patients with a brain glioblastoma (median age 55.2 years) and harboring a spinal cord metastasis were included. The median overall survival as 16.0 months (range, 9.8–22.2). The median spinal cord Metastasis Free Survival (time interval between the glioblastoma diagnosis and the spinal cord metastasis diagnosis) was 13.6 months (range, 0.0–27.9). The occurrence of a spinal cord metastasis diagnosis greatly impacted neurological status: 57.2% of patients were not ambulatory, which contributed to dramatically decreased Karnofsky Performance Status (KPS) scores (12/14, 85.7% with a KPS score ≤ 70). The median overall survival following spinal cord metastasis was 3.3 months (range, 1.3–5.3). Patients with a cerebral ventricle effraction during the initial brain surgery had a shorter spinal cord Metastasis Free Survival (6.6
vs
18.3 months, p = 0.023). Out of the 14 patients, eleven (78.6%) had a brain IDH-wildtype glioblastoma.
Conclusions
Spinal cord metastasis from a brain IDH-wildtype glioblastoma has a poor prognosis. Spinal MRI can be proposed during the follow-up of glioblastoma patients especially those who have benefited from cerebral surgical resection with opening of the cerebral ventricles. |
| doi_str_mv | 10.1007/s11060-023-04298-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2792901435</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2811093549</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-eeae93322bd8fa59ee1e5e332a7654c85df3dc009c4b16421acc5cc0a451f47d3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMo7rr6BzxIwYuX6qSTNJujLn6B6EXBW0jTdO3SNmvSHvbfG-2q4EEYGJh55g15CDmmcE4BxEWgFHJIIcMUWCbnKe6QKeUCU4ECd8kUaC5SLtnrhByEsAIAJpDukwnmUlKEfEquHnU_eN0kb3Xond8krkrCuu7ixDhfJq3tdYhVh6Tyrk0Kr-suWTa1K5q4cK0Oh2Sv0k2wR9s-Iy8318-Lu_Th6fZ-cfmQGhS8T63VViJmWVHOK82ltdRyGwda5JyZOS8rLA2ANKygOcuoNoYbA5pxWjFR4oycjblr794HG3rV1sHYptGddUNQmZCZBMqQR_T0D7pyg4-fitQ8WpPImYxUNlLGuxC8rdTa1632G0VBfRpWo2EVDasvwwrj0ck2eihaW_6cfCuNAI5AiKtuaf3v2__EfgDO-oZN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2811093549</pqid></control><display><type>article</type><title>Natural history of spinal cord metastasis from brain glioblastomas</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Amelot, Aymeric ; Terrier, Louis-Marie ; Cognacq, Gabrielle ; Jecko, Vincent ; Marlier, Benoit ; Seizeur, Romuald ; Emery, Evelyne ; Bauchet, Luc ; Roualdes, Vincent ; Voirin, Jimmy ; Joubert, Christophe ; Mandonnet, Emmanuel ; Lemnos, Leslie ; Mathon, Bertrand ; Le Reste, Pierre-Jean ; Coca, Andres ; Petit, Antoine ; Rigau, Valérie ; Mokhtari, Karima ; Rousseau, Audrey ; Metellus, Philippe ; Figarella-Branger, Dominique ; Gauchotte, Guillaume ; Farah, Kaissar ; Pallud, Johan ; Zemmoura, Ilyess</creator><creatorcontrib>Amelot, Aymeric ; Terrier, Louis-Marie ; Cognacq, Gabrielle ; Jecko, Vincent ; Marlier, Benoit ; Seizeur, Romuald ; Emery, Evelyne ; Bauchet, Luc ; Roualdes, Vincent ; Voirin, Jimmy ; Joubert, Christophe ; Mandonnet, Emmanuel ; Lemnos, Leslie ; Mathon, Bertrand ; Le Reste, Pierre-Jean ; Coca, Andres ; Petit, Antoine ; Rigau, Valérie ; Mokhtari, Karima ; Rousseau, Audrey ; Metellus, Philippe ; Figarella-Branger, Dominique ; Gauchotte, Guillaume ; Farah, Kaissar ; Pallud, Johan ; Zemmoura, Ilyess</creatorcontrib><description>Background and Objectives
Spinal cord metastasis arising from an intracranial glioblastoma is a rare and late event during the natural course of the disease. These pathological entities remain poorly characterized. This study aimed to identify and investigate the timeline, clinical and imaging findings, and prognostic factors of spinal cord metastasis from a glioblastoma.
Methods
Consecutive histopathological cases of spinal cord metastasis from glioblastomas in adults entered in the French nationwide database between January 2004 and 2016 were screened.
Results
Overall, 14 adult patients with a brain glioblastoma (median age 55.2 years) and harboring a spinal cord metastasis were included. The median overall survival as 16.0 months (range, 9.8–22.2). The median spinal cord Metastasis Free Survival (time interval between the glioblastoma diagnosis and the spinal cord metastasis diagnosis) was 13.6 months (range, 0.0–27.9). The occurrence of a spinal cord metastasis diagnosis greatly impacted neurological status: 57.2% of patients were not ambulatory, which contributed to dramatically decreased Karnofsky Performance Status (KPS) scores (12/14, 85.7% with a KPS score ≤ 70). The median overall survival following spinal cord metastasis was 3.3 months (range, 1.3–5.3). Patients with a cerebral ventricle effraction during the initial brain surgery had a shorter spinal cord Metastasis Free Survival (6.6
vs
18.3 months, p = 0.023). Out of the 14 patients, eleven (78.6%) had a brain IDH-wildtype glioblastoma.
Conclusions
Spinal cord metastasis from a brain IDH-wildtype glioblastoma has a poor prognosis. Spinal MRI can be proposed during the follow-up of glioblastoma patients especially those who have benefited from cerebral surgical resection with opening of the cerebral ventricles.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-023-04298-3</identifier><identifier>PMID: 36991306</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Brain - pathology ; Brain Neoplasms ; Diagnosis ; Glioblastoma ; Glioblastoma - pathology ; Humans ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Middle Aged ; Neuroimaging ; Neurology ; Oncology ; Patients ; Prognosis ; Retrospective Studies ; Spinal cord ; Spinal Cord Neoplasms - diagnostic imaging ; Spinal Cord Neoplasms - surgery ; Survival ; Ventricle ; Ventricles (cerebral)</subject><ispartof>Journal of neuro-oncology, 2023-04, Vol.162 (2), p.373-382</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. corrected publication 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-eeae93322bd8fa59ee1e5e332a7654c85df3dc009c4b16421acc5cc0a451f47d3</citedby><cites>FETCH-LOGICAL-c375t-eeae93322bd8fa59ee1e5e332a7654c85df3dc009c4b16421acc5cc0a451f47d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11060-023-04298-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11060-023-04298-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36991306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amelot, Aymeric</creatorcontrib><creatorcontrib>Terrier, Louis-Marie</creatorcontrib><creatorcontrib>Cognacq, Gabrielle</creatorcontrib><creatorcontrib>Jecko, Vincent</creatorcontrib><creatorcontrib>Marlier, Benoit</creatorcontrib><creatorcontrib>Seizeur, Romuald</creatorcontrib><creatorcontrib>Emery, Evelyne</creatorcontrib><creatorcontrib>Bauchet, Luc</creatorcontrib><creatorcontrib>Roualdes, Vincent</creatorcontrib><creatorcontrib>Voirin, Jimmy</creatorcontrib><creatorcontrib>Joubert, Christophe</creatorcontrib><creatorcontrib>Mandonnet, Emmanuel</creatorcontrib><creatorcontrib>Lemnos, Leslie</creatorcontrib><creatorcontrib>Mathon, Bertrand</creatorcontrib><creatorcontrib>Le Reste, Pierre-Jean</creatorcontrib><creatorcontrib>Coca, Andres</creatorcontrib><creatorcontrib>Petit, Antoine</creatorcontrib><creatorcontrib>Rigau, Valérie</creatorcontrib><creatorcontrib>Mokhtari, Karima</creatorcontrib><creatorcontrib>Rousseau, Audrey</creatorcontrib><creatorcontrib>Metellus, Philippe</creatorcontrib><creatorcontrib>Figarella-Branger, Dominique</creatorcontrib><creatorcontrib>Gauchotte, Guillaume</creatorcontrib><creatorcontrib>Farah, Kaissar</creatorcontrib><creatorcontrib>Pallud, Johan</creatorcontrib><creatorcontrib>Zemmoura, Ilyess</creatorcontrib><title>Natural history of spinal cord metastasis from brain glioblastomas</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>Background and Objectives
Spinal cord metastasis arising from an intracranial glioblastoma is a rare and late event during the natural course of the disease. These pathological entities remain poorly characterized. This study aimed to identify and investigate the timeline, clinical and imaging findings, and prognostic factors of spinal cord metastasis from a glioblastoma.
Methods
Consecutive histopathological cases of spinal cord metastasis from glioblastomas in adults entered in the French nationwide database between January 2004 and 2016 were screened.
Results
Overall, 14 adult patients with a brain glioblastoma (median age 55.2 years) and harboring a spinal cord metastasis were included. The median overall survival as 16.0 months (range, 9.8–22.2). The median spinal cord Metastasis Free Survival (time interval between the glioblastoma diagnosis and the spinal cord metastasis diagnosis) was 13.6 months (range, 0.0–27.9). The occurrence of a spinal cord metastasis diagnosis greatly impacted neurological status: 57.2% of patients were not ambulatory, which contributed to dramatically decreased Karnofsky Performance Status (KPS) scores (12/14, 85.7% with a KPS score ≤ 70). The median overall survival following spinal cord metastasis was 3.3 months (range, 1.3–5.3). Patients with a cerebral ventricle effraction during the initial brain surgery had a shorter spinal cord Metastasis Free Survival (6.6
vs
18.3 months, p = 0.023). Out of the 14 patients, eleven (78.6%) had a brain IDH-wildtype glioblastoma.
Conclusions
Spinal cord metastasis from a brain IDH-wildtype glioblastoma has a poor prognosis. Spinal MRI can be proposed during the follow-up of glioblastoma patients especially those who have benefited from cerebral surgical resection with opening of the cerebral ventricles.</description><subject>Adult</subject><subject>Brain - pathology</subject><subject>Brain Neoplasms</subject><subject>Diagnosis</subject><subject>Glioblastoma</subject><subject>Glioblastoma - pathology</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Spinal cord</subject><subject>Spinal Cord Neoplasms - diagnostic imaging</subject><subject>Spinal Cord Neoplasms - surgery</subject><subject>Survival</subject><subject>Ventricle</subject><subject>Ventricles (cerebral)</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6BzxIwYuX6qSTNJujLn6B6EXBW0jTdO3SNmvSHvbfG-2q4EEYGJh55g15CDmmcE4BxEWgFHJIIcMUWCbnKe6QKeUCU4ECd8kUaC5SLtnrhByEsAIAJpDukwnmUlKEfEquHnU_eN0kb3Xond8krkrCuu7ixDhfJq3tdYhVh6Tyrk0Kr-suWTa1K5q4cK0Oh2Sv0k2wR9s-Iy8318-Lu_Th6fZ-cfmQGhS8T63VViJmWVHOK82ltdRyGwda5JyZOS8rLA2ANKygOcuoNoYbA5pxWjFR4oycjblr794HG3rV1sHYptGddUNQmZCZBMqQR_T0D7pyg4-fitQ8WpPImYxUNlLGuxC8rdTa1632G0VBfRpWo2EVDasvwwrj0ck2eihaW_6cfCuNAI5AiKtuaf3v2__EfgDO-oZN</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Amelot, Aymeric</creator><creator>Terrier, Louis-Marie</creator><creator>Cognacq, Gabrielle</creator><creator>Jecko, Vincent</creator><creator>Marlier, Benoit</creator><creator>Seizeur, Romuald</creator><creator>Emery, Evelyne</creator><creator>Bauchet, Luc</creator><creator>Roualdes, Vincent</creator><creator>Voirin, Jimmy</creator><creator>Joubert, Christophe</creator><creator>Mandonnet, Emmanuel</creator><creator>Lemnos, Leslie</creator><creator>Mathon, Bertrand</creator><creator>Le Reste, Pierre-Jean</creator><creator>Coca, Andres</creator><creator>Petit, Antoine</creator><creator>Rigau, Valérie</creator><creator>Mokhtari, Karima</creator><creator>Rousseau, Audrey</creator><creator>Metellus, Philippe</creator><creator>Figarella-Branger, Dominique</creator><creator>Gauchotte, Guillaume</creator><creator>Farah, Kaissar</creator><creator>Pallud, Johan</creator><creator>Zemmoura, Ilyess</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20230401</creationdate><title>Natural history of spinal cord metastasis from brain glioblastomas</title><author>Amelot, Aymeric ; Terrier, Louis-Marie ; Cognacq, Gabrielle ; Jecko, Vincent ; Marlier, Benoit ; Seizeur, Romuald ; Emery, Evelyne ; Bauchet, Luc ; Roualdes, Vincent ; Voirin, Jimmy ; Joubert, Christophe ; Mandonnet, Emmanuel ; Lemnos, Leslie ; Mathon, Bertrand ; Le Reste, Pierre-Jean ; Coca, Andres ; Petit, Antoine ; Rigau, Valérie ; Mokhtari, Karima ; Rousseau, Audrey ; Metellus, Philippe ; Figarella-Branger, Dominique ; Gauchotte, Guillaume ; Farah, Kaissar ; Pallud, Johan ; Zemmoura, Ilyess</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-eeae93322bd8fa59ee1e5e332a7654c85df3dc009c4b16421acc5cc0a451f47d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Brain - pathology</topic><topic>Brain Neoplasms</topic><topic>Diagnosis</topic><topic>Glioblastoma</topic><topic>Glioblastoma - pathology</topic><topic>Humans</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Oncology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Spinal cord</topic><topic>Spinal Cord Neoplasms - diagnostic imaging</topic><topic>Spinal Cord Neoplasms - surgery</topic><topic>Survival</topic><topic>Ventricle</topic><topic>Ventricles (cerebral)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amelot, Aymeric</creatorcontrib><creatorcontrib>Terrier, Louis-Marie</creatorcontrib><creatorcontrib>Cognacq, Gabrielle</creatorcontrib><creatorcontrib>Jecko, Vincent</creatorcontrib><creatorcontrib>Marlier, Benoit</creatorcontrib><creatorcontrib>Seizeur, Romuald</creatorcontrib><creatorcontrib>Emery, Evelyne</creatorcontrib><creatorcontrib>Bauchet, Luc</creatorcontrib><creatorcontrib>Roualdes, Vincent</creatorcontrib><creatorcontrib>Voirin, Jimmy</creatorcontrib><creatorcontrib>Joubert, Christophe</creatorcontrib><creatorcontrib>Mandonnet, Emmanuel</creatorcontrib><creatorcontrib>Lemnos, Leslie</creatorcontrib><creatorcontrib>Mathon, Bertrand</creatorcontrib><creatorcontrib>Le Reste, Pierre-Jean</creatorcontrib><creatorcontrib>Coca, Andres</creatorcontrib><creatorcontrib>Petit, Antoine</creatorcontrib><creatorcontrib>Rigau, Valérie</creatorcontrib><creatorcontrib>Mokhtari, Karima</creatorcontrib><creatorcontrib>Rousseau, Audrey</creatorcontrib><creatorcontrib>Metellus, Philippe</creatorcontrib><creatorcontrib>Figarella-Branger, Dominique</creatorcontrib><creatorcontrib>Gauchotte, Guillaume</creatorcontrib><creatorcontrib>Farah, Kaissar</creatorcontrib><creatorcontrib>Pallud, Johan</creatorcontrib><creatorcontrib>Zemmoura, Ilyess</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuro-oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amelot, Aymeric</au><au>Terrier, Louis-Marie</au><au>Cognacq, Gabrielle</au><au>Jecko, Vincent</au><au>Marlier, Benoit</au><au>Seizeur, Romuald</au><au>Emery, Evelyne</au><au>Bauchet, Luc</au><au>Roualdes, Vincent</au><au>Voirin, Jimmy</au><au>Joubert, Christophe</au><au>Mandonnet, Emmanuel</au><au>Lemnos, Leslie</au><au>Mathon, Bertrand</au><au>Le Reste, Pierre-Jean</au><au>Coca, Andres</au><au>Petit, Antoine</au><au>Rigau, Valérie</au><au>Mokhtari, Karima</au><au>Rousseau, Audrey</au><au>Metellus, Philippe</au><au>Figarella-Branger, Dominique</au><au>Gauchotte, Guillaume</au><au>Farah, Kaissar</au><au>Pallud, Johan</au><au>Zemmoura, Ilyess</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural history of spinal cord metastasis from brain glioblastomas</atitle><jtitle>Journal of neuro-oncology</jtitle><stitle>J Neurooncol</stitle><addtitle>J Neurooncol</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>162</volume><issue>2</issue><spage>373</spage><epage>382</epage><pages>373-382</pages><issn>0167-594X</issn><eissn>1573-7373</eissn><abstract>Background and Objectives
Spinal cord metastasis arising from an intracranial glioblastoma is a rare and late event during the natural course of the disease. These pathological entities remain poorly characterized. This study aimed to identify and investigate the timeline, clinical and imaging findings, and prognostic factors of spinal cord metastasis from a glioblastoma.
Methods
Consecutive histopathological cases of spinal cord metastasis from glioblastomas in adults entered in the French nationwide database between January 2004 and 2016 were screened.
Results
Overall, 14 adult patients with a brain glioblastoma (median age 55.2 years) and harboring a spinal cord metastasis were included. The median overall survival as 16.0 months (range, 9.8–22.2). The median spinal cord Metastasis Free Survival (time interval between the glioblastoma diagnosis and the spinal cord metastasis diagnosis) was 13.6 months (range, 0.0–27.9). The occurrence of a spinal cord metastasis diagnosis greatly impacted neurological status: 57.2% of patients were not ambulatory, which contributed to dramatically decreased Karnofsky Performance Status (KPS) scores (12/14, 85.7% with a KPS score ≤ 70). The median overall survival following spinal cord metastasis was 3.3 months (range, 1.3–5.3). Patients with a cerebral ventricle effraction during the initial brain surgery had a shorter spinal cord Metastasis Free Survival (6.6
vs
18.3 months, p = 0.023). Out of the 14 patients, eleven (78.6%) had a brain IDH-wildtype glioblastoma.
Conclusions
Spinal cord metastasis from a brain IDH-wildtype glioblastoma has a poor prognosis. Spinal MRI can be proposed during the follow-up of glioblastoma patients especially those who have benefited from cerebral surgical resection with opening of the cerebral ventricles.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36991306</pmid><doi>10.1007/s11060-023-04298-3</doi><tpages>10</tpages></addata></record> |
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| issn | 0167-594X 1573-7373 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Brain - pathology Brain Neoplasms Diagnosis Glioblastoma Glioblastoma - pathology Humans Medical prognosis Medicine Medicine & Public Health Metastases Metastasis Middle Aged Neuroimaging Neurology Oncology Patients Prognosis Retrospective Studies Spinal cord Spinal Cord Neoplasms - diagnostic imaging Spinal Cord Neoplasms - surgery Survival Ventricle Ventricles (cerebral) |
| title | Natural history of spinal cord metastasis from brain glioblastomas |
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