Structural features of the Notch ankyrin domain-Deltex WWE2 domain heterodimer determined by NMR spectroscopy and functional implications

The Notch signaling pathway, an important cell fate determination pathway, is modulated by the ubiquitin ligase Deltex. Here, we investigate the structural basis for Deltex-Notch interaction. We used nuclear magnetic resonance (NMR) spectroscopy to assign the backbone of the Drosophila Deltex WWE2 d...

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Veröffentlicht in:	Structure (London) 2023-05, Vol.31 (5), p.584-594.e5
Hauptverfasser:	Carter, Andrea A., Ramsey, Kristen M., Hatem, Christine L., Sherry, Kathryn P., Majumdar, Ananya, Barrick, Doug
Format:	Artikel
Sprache:	eng
Schlagworte:	ankyrin repeats Deltex NMR Notch Notch signaling protein-protein interactions RING domain ubiquitin ligase WWE2 motifs
Online-Zugang:	Volltext
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