Single‐cell analysis of localized prostate cancer patients links high Gleason score with an immunosuppressive profile

Background Evading immune surveillance is a hallmark for the development of multiple cancer types. Whether immune evasion contributes to the pathogenesis of high‐grade prostate cancer (HGPCa) remains an area of active inquiry. Methods Through single‐cell RNA sequencing and multicolor flow cytometry...

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Veröffentlicht in:	The Prostate 2023-06, Vol.83 (9), p.840-849
Hauptverfasser:	Adorno Febles, Victor R., Hao, Yuan, Ahsan, Aarif, Wu, Jiansheng, Qian, Yingzhi, Zhong, Hua, Loeb, Stacy, Makarov, Danil V., Lepor, Herbert, Wysock, James, Taneja, Samir S., Huang, William C., Becker, Daniel J., Balar, Arjun V., Melamed, Jonathan, Deng, Fang‐Ming, Ren, Qinghu, Kufe, Donald, Wong, Kwok‐Kin, Adeegbe, Dennis O., Deng, Jiehui, Wise, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptors Antigens CD8 antigen CD8+ T cells CD8-Positive T-Lymphocytes - pathology CTLA-4 protein CXCL13 protein Effector cells Flow cytometry Gleason score Humans immune profiling Immunoregulation Immunosuppressive Agents Immunosurveillance Immunotherapy Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating Macrophages Male Microenvironments Myeloid cells Neoplasm Grading Pathogenesis Peripheral blood Prostate - pathology Prostate cancer Prostate-Specific Antigen Prostatectomy Prostatic Neoplasms - pathology scRNA sequencing Single-Cell Analysis Tumor Microenvironment Tumors
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