Src inhibition induces mitotic arrest associated with chromosomal passenger complex

The non-receptor tyrosine kinase Src plays a key role in cell division, migration, adhesion, and survival. Src is overactivated in several cancers, where it transmits signals that promote cell survival, mitosis, and other important cancer hallmarks. Src is therefore a promising target in cancer ther...

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Veröffentlicht in:	Cell and tissue research 2023-06, Vol.392 (3), p.733-743
Hauptverfasser:	Yang, Song, Luo, Youguang, Yang, Mulin, Ni, Hua, Yin, Hanxiao, Hu, Ming, Liu, Min, Zhou, Jun, Yang, Yunfan, Li, Dengwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aurora B protein Biomedical and Life Sciences Biomedicine Cancer Care and treatment Cell division Cell migration Cell survival Chromosomal Proteins, Non-Histone - metabolism Chromosomes Chromosomes - metabolism Cytoskeleton - metabolism Health aspects Human Genetics INCENP protein Kinases Mitosis Molecular Medicine Molecular modelling Protein Serine-Threonine Kinases - metabolism Protein-tyrosine kinase receptors Proteomics Regular Article Spindle Apparatus - genetics Spindle Apparatus - metabolism Tyrosine Wildlife conservation
Online-Zugang:	Volltext
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