Characterization of the role of Kunitz‐type protease inhibitor domain in dimerization of amyloid precursor protein

A major difference between amyloid precursor protein (APP) isoforms (APP695 and APP751) is the existence of a Kunitz type protease inhibitor (KPI) domain which has a significant impact on the homo‐ and hetero‐dimerization of APP isoforms. However, the exact molecular mechanisms of dimer formation re...

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Veröffentlicht in:	Journal of computational chemistry 2023-06, Vol.44 (15), p.1437-1445
Hauptverfasser:	Byun, Jinyoung, Vellampatti, Srivithya, Chatterjee, Prathit, Hwang, Sun Ha, Kim, Byoung Choul, Lee, Juyong
Format:	Artikel
Sprache:	eng
Schlagworte:	AlphaFold2 Amyloid beta-Protein Precursor - metabolism amyloid precursor protein Binding Dimerization Dimers Domains Free energy Precursors Protease Protease Inhibitors Protein A Protein Domains Protein Isoforms - metabolism Proteins protein–protein interaction single molecule pull down assay
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