Di‐(2‐ethylhexyl) phthalate (DEHP) promoted hepatic lipid accumulation by activating Notch signaling pathway

Di‐(2‐ethylhexyl) phthalate (DEHP) and mono‐2‐ethylhexyl phthalate (MEHP) can induce hepatic lipid metabolism disorders, while the molecular mechanism still remain unknown. We aim to explore the underlying mechanism of Notch signaling pathway on hepatic lipid accumulation induced by DEHP/MEHP. A tot...

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Veröffentlicht in:	Environmental toxicology 2023-07, Vol.38 (7), p.1628-1640
Hauptverfasser:	Zhang, Yuezhu, Qian, Honghao, Wang, Jia, Zhu, Ying, Miao, Xiaohan, Li, Xu, Yin, Jianli, Zhang, Ruxuan, Ye, Jiaming, Huo, Chuanyi, Zhao, Weisen, Ye, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Aspirin Dioctyl phthalate Di‐(2‐ethylhexyl) phthalate (DEHP) Gene expression Hepatocytes Immunofluorescence Inflammation lipid accumulation Lipid metabolism Lipids Liver Metabolism Molecular modelling mono‐2‐ethylhexyl phthalate (MEHP) Notch protein Notch signaling pathway Nucleotide sequence Phthalates Receptors Signal transduction Signaling
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