Sex and age differences in the association between high sensitivity C-reactive protein and all-cause mortality: A 12-year prospective cohort study
To explore the influence of age on hs-CRP among men and women and investigate the impact of hs-CRP on all-cause death, this prospective cohort enrolled 4128 community adults from 2009 to 2022 for all-cause death. Age and sex-specific hs-CRP percentile curves were generated using the GAMLSS method. C...
Gespeichert in:
| Veröffentlicht in: | Mechanisms of ageing and development 2023-04, Vol.211, p.111804-111804, Article 111804 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 111804 |
|---|---|
| container_issue | |
| container_start_page | 111804 |
| container_title | Mechanisms of ageing and development |
| container_volume | 211 |
| creator | Bafei, Solim Essomandan Clémence Yang, Song Chen, Changying Gu, Xincheng Mu, Jialing Liu, Fangyuan Sun, Junxiang Zhuang, Qian Wei, Pengfei Zhao, Xianghai Chen, Yanchun Yin, Yunjie Xie, Hankun Shen, Chong |
| description | To explore the influence of age on hs-CRP among men and women and investigate the impact of hs-CRP on all-cause death, this prospective cohort enrolled 4128 community adults from 2009 to 2022 for all-cause death. Age and sex-specific hs-CRP percentile curves were generated using the GAMLSS method. Cox-proportional hazard regression analysis was applied to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs). During the follow-up with a median of 12.59 years, 701 cases of all-cause death were identified. Among men, the smoothed centile curves of hs-CRP gradually increased from age 35 onwards whereas, the smoothed centile curves of hs-CRP continuously increased as age increased among women. Compared with the reference group, the adjusted HR of the association between elevated hs-CRP and all-cause death was 1.33 (95 % CI: 1.11–1.61). The adjusted HRs of the associations between elevated hs-CRP and all-cause death were higher in women [1.40 (95 % CI: 1.07–1.83)] than men [1.28 (95 % CI: 0.99–1.65) and in subjects aged |
| doi_str_mv | 10.1016/j.mad.2023.111804 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2791708049</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0047637423000301</els_id><sourcerecordid>2791708049</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-d0bc1f556b89978d9ec1dfe1fcf2673c12ceeacfbcc176e11fb5c0ca131030fc3</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS0EotPCA7BBXrLJ4OtknARW1QgoUiUWLWvLub7ueJSfwXZa5jV4YjykdNmVdaXvHB2fw9g7EGsQoD7u14OxaylkuQaARlQv2AqaWhZKgnrJVkJUdaHKujpj5zHuhRBQSfWanZWqVbWomhX7c0O_uRktN3fErXeOAo1IkfuRpx1xE-OE3iQ_jbyj9EA08p2_2_FIY_TJ3_t05NsikMF8ED-EKVHW_rPs-wLNHIkPU0imz-gnfslBFkcy4YTGAy0ynHYZ4THN9viGvXKmj_T28b1gP79-ud1eFdc_vn3fXl4XWG7KVFjRIbjNRnVN29aNbQnBOgKHTqq6RJBIOZXrEKFWBOC6DQo0UIIohcPygn1YfHOQXzPFpAcfkfrejDTNUcu6hVrkVtuMwoJizhwDOX0IfjDhqEHo0xR6r_MU-jSFXqbImveP9nM3kH1S_O8-A58XgPIn7z0FHdGfyrc-5Fq0nfwz9n8BQZCctg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2791708049</pqid></control><display><type>article</type><title>Sex and age differences in the association between high sensitivity C-reactive protein and all-cause mortality: A 12-year prospective cohort study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Bafei, Solim Essomandan Clémence ; Yang, Song ; Chen, Changying ; Gu, Xincheng ; Mu, Jialing ; Liu, Fangyuan ; Sun, Junxiang ; Zhuang, Qian ; Wei, Pengfei ; Zhao, Xianghai ; Chen, Yanchun ; Yin, Yunjie ; Xie, Hankun ; Shen, Chong</creator><creatorcontrib>Bafei, Solim Essomandan Clémence ; Yang, Song ; Chen, Changying ; Gu, Xincheng ; Mu, Jialing ; Liu, Fangyuan ; Sun, Junxiang ; Zhuang, Qian ; Wei, Pengfei ; Zhao, Xianghai ; Chen, Yanchun ; Yin, Yunjie ; Xie, Hankun ; Shen, Chong</creatorcontrib><description>To explore the influence of age on hs-CRP among men and women and investigate the impact of hs-CRP on all-cause death, this prospective cohort enrolled 4128 community adults from 2009 to 2022 for all-cause death. Age and sex-specific hs-CRP percentile curves were generated using the GAMLSS method. Cox-proportional hazard regression analysis was applied to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs). During the follow-up with a median of 12.59 years, 701 cases of all-cause death were identified. Among men, the smoothed centile curves of hs-CRP gradually increased from age 35 onwards whereas, the smoothed centile curves of hs-CRP continuously increased as age increased among women. Compared with the reference group, the adjusted HR of the association between elevated hs-CRP and all-cause death was 1.33 (95 % CI: 1.11–1.61). The adjusted HRs of the associations between elevated hs-CRP and all-cause death were higher in women [1.40 (95 % CI: 1.07–1.83)] than men [1.28 (95 % CI: 0.99–1.65) and in subjects aged < 65 years [1.77 (95 % CI: 1.19–2.62)] than in subjects aged ≥ 65 years [1.27 (95 % CI: 1.03–1.57)]. Our findings highlight the need of investigating sex and age differences in biological pathways that link inflammation and mortality.
•The age-related distribution of hs-CRP varied among men and women.•There was a linear association between hs-CRP and the hazard of all-cause death among men and women.•Elevated hs-CRP was associated with an increased risk of all-cause death in women and subjects aged below 65 years.•There is a need of investigating sex and age differences in the biological pathways that link inflammation and mortality.</description><identifier>ISSN: 0047-6374</identifier><identifier>EISSN: 1872-6216</identifier><identifier>DOI: 10.1016/j.mad.2023.111804</identifier><identifier>PMID: 36967048</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Age ; All-cause death ; C-Reactive Protein - metabolism ; CVD death ; Female ; Gender ; Hs-CRP ; Humans ; Inflammation ; Male ; Proportional Hazards Models ; Prospective Studies ; Risk Factors</subject><ispartof>Mechanisms of ageing and development, 2023-04, Vol.211, p.111804-111804, Article 111804</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-d0bc1f556b89978d9ec1dfe1fcf2673c12ceeacfbcc176e11fb5c0ca131030fc3</citedby><cites>FETCH-LOGICAL-c353t-d0bc1f556b89978d9ec1dfe1fcf2673c12ceeacfbcc176e11fb5c0ca131030fc3</cites><orcidid>0000-0001-6447-6591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mad.2023.111804$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36967048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bafei, Solim Essomandan Clémence</creatorcontrib><creatorcontrib>Yang, Song</creatorcontrib><creatorcontrib>Chen, Changying</creatorcontrib><creatorcontrib>Gu, Xincheng</creatorcontrib><creatorcontrib>Mu, Jialing</creatorcontrib><creatorcontrib>Liu, Fangyuan</creatorcontrib><creatorcontrib>Sun, Junxiang</creatorcontrib><creatorcontrib>Zhuang, Qian</creatorcontrib><creatorcontrib>Wei, Pengfei</creatorcontrib><creatorcontrib>Zhao, Xianghai</creatorcontrib><creatorcontrib>Chen, Yanchun</creatorcontrib><creatorcontrib>Yin, Yunjie</creatorcontrib><creatorcontrib>Xie, Hankun</creatorcontrib><creatorcontrib>Shen, Chong</creatorcontrib><title>Sex and age differences in the association between high sensitivity C-reactive protein and all-cause mortality: A 12-year prospective cohort study</title><title>Mechanisms of ageing and development</title><addtitle>Mech Ageing Dev</addtitle><description>To explore the influence of age on hs-CRP among men and women and investigate the impact of hs-CRP on all-cause death, this prospective cohort enrolled 4128 community adults from 2009 to 2022 for all-cause death. Age and sex-specific hs-CRP percentile curves were generated using the GAMLSS method. Cox-proportional hazard regression analysis was applied to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs). During the follow-up with a median of 12.59 years, 701 cases of all-cause death were identified. Among men, the smoothed centile curves of hs-CRP gradually increased from age 35 onwards whereas, the smoothed centile curves of hs-CRP continuously increased as age increased among women. Compared with the reference group, the adjusted HR of the association between elevated hs-CRP and all-cause death was 1.33 (95 % CI: 1.11–1.61). The adjusted HRs of the associations between elevated hs-CRP and all-cause death were higher in women [1.40 (95 % CI: 1.07–1.83)] than men [1.28 (95 % CI: 0.99–1.65) and in subjects aged < 65 years [1.77 (95 % CI: 1.19–2.62)] than in subjects aged ≥ 65 years [1.27 (95 % CI: 1.03–1.57)]. Our findings highlight the need of investigating sex and age differences in biological pathways that link inflammation and mortality.
•The age-related distribution of hs-CRP varied among men and women.•There was a linear association between hs-CRP and the hazard of all-cause death among men and women.•Elevated hs-CRP was associated with an increased risk of all-cause death in women and subjects aged below 65 years.•There is a need of investigating sex and age differences in the biological pathways that link inflammation and mortality.</description><subject>Age</subject><subject>All-cause death</subject><subject>C-Reactive Protein - metabolism</subject><subject>CVD death</subject><subject>Female</subject><subject>Gender</subject><subject>Hs-CRP</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Male</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EotPCA7BBXrLJ4OtknARW1QgoUiUWLWvLub7ueJSfwXZa5jV4YjykdNmVdaXvHB2fw9g7EGsQoD7u14OxaylkuQaARlQv2AqaWhZKgnrJVkJUdaHKujpj5zHuhRBQSfWanZWqVbWomhX7c0O_uRktN3fErXeOAo1IkfuRpx1xE-OE3iQ_jbyj9EA08p2_2_FIY_TJ3_t05NsikMF8ED-EKVHW_rPs-wLNHIkPU0imz-gnfslBFkcy4YTGAy0ynHYZ4THN9viGvXKmj_T28b1gP79-ud1eFdc_vn3fXl4XWG7KVFjRIbjNRnVN29aNbQnBOgKHTqq6RJBIOZXrEKFWBOC6DQo0UIIohcPygn1YfHOQXzPFpAcfkfrejDTNUcu6hVrkVtuMwoJizhwDOX0IfjDhqEHo0xR6r_MU-jSFXqbImveP9nM3kH1S_O8-A58XgPIn7z0FHdGfyrc-5Fq0nfwz9n8BQZCctg</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Bafei, Solim Essomandan Clémence</creator><creator>Yang, Song</creator><creator>Chen, Changying</creator><creator>Gu, Xincheng</creator><creator>Mu, Jialing</creator><creator>Liu, Fangyuan</creator><creator>Sun, Junxiang</creator><creator>Zhuang, Qian</creator><creator>Wei, Pengfei</creator><creator>Zhao, Xianghai</creator><creator>Chen, Yanchun</creator><creator>Yin, Yunjie</creator><creator>Xie, Hankun</creator><creator>Shen, Chong</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6447-6591</orcidid></search><sort><creationdate>202304</creationdate><title>Sex and age differences in the association between high sensitivity C-reactive protein and all-cause mortality: A 12-year prospective cohort study</title><author>Bafei, Solim Essomandan Clémence ; Yang, Song ; Chen, Changying ; Gu, Xincheng ; Mu, Jialing ; Liu, Fangyuan ; Sun, Junxiang ; Zhuang, Qian ; Wei, Pengfei ; Zhao, Xianghai ; Chen, Yanchun ; Yin, Yunjie ; Xie, Hankun ; Shen, Chong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-d0bc1f556b89978d9ec1dfe1fcf2673c12ceeacfbcc176e11fb5c0ca131030fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>All-cause death</topic><topic>C-Reactive Protein - metabolism</topic><topic>CVD death</topic><topic>Female</topic><topic>Gender</topic><topic>Hs-CRP</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Male</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bafei, Solim Essomandan Clémence</creatorcontrib><creatorcontrib>Yang, Song</creatorcontrib><creatorcontrib>Chen, Changying</creatorcontrib><creatorcontrib>Gu, Xincheng</creatorcontrib><creatorcontrib>Mu, Jialing</creatorcontrib><creatorcontrib>Liu, Fangyuan</creatorcontrib><creatorcontrib>Sun, Junxiang</creatorcontrib><creatorcontrib>Zhuang, Qian</creatorcontrib><creatorcontrib>Wei, Pengfei</creatorcontrib><creatorcontrib>Zhao, Xianghai</creatorcontrib><creatorcontrib>Chen, Yanchun</creatorcontrib><creatorcontrib>Yin, Yunjie</creatorcontrib><creatorcontrib>Xie, Hankun</creatorcontrib><creatorcontrib>Shen, Chong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bafei, Solim Essomandan Clémence</au><au>Yang, Song</au><au>Chen, Changying</au><au>Gu, Xincheng</au><au>Mu, Jialing</au><au>Liu, Fangyuan</au><au>Sun, Junxiang</au><au>Zhuang, Qian</au><au>Wei, Pengfei</au><au>Zhao, Xianghai</au><au>Chen, Yanchun</au><au>Yin, Yunjie</au><au>Xie, Hankun</au><au>Shen, Chong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex and age differences in the association between high sensitivity C-reactive protein and all-cause mortality: A 12-year prospective cohort study</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>2023-04</date><risdate>2023</risdate><volume>211</volume><spage>111804</spage><epage>111804</epage><pages>111804-111804</pages><artnum>111804</artnum><issn>0047-6374</issn><eissn>1872-6216</eissn><abstract>To explore the influence of age on hs-CRP among men and women and investigate the impact of hs-CRP on all-cause death, this prospective cohort enrolled 4128 community adults from 2009 to 2022 for all-cause death. Age and sex-specific hs-CRP percentile curves were generated using the GAMLSS method. Cox-proportional hazard regression analysis was applied to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs). During the follow-up with a median of 12.59 years, 701 cases of all-cause death were identified. Among men, the smoothed centile curves of hs-CRP gradually increased from age 35 onwards whereas, the smoothed centile curves of hs-CRP continuously increased as age increased among women. Compared with the reference group, the adjusted HR of the association between elevated hs-CRP and all-cause death was 1.33 (95 % CI: 1.11–1.61). The adjusted HRs of the associations between elevated hs-CRP and all-cause death were higher in women [1.40 (95 % CI: 1.07–1.83)] than men [1.28 (95 % CI: 0.99–1.65) and in subjects aged < 65 years [1.77 (95 % CI: 1.19–2.62)] than in subjects aged ≥ 65 years [1.27 (95 % CI: 1.03–1.57)]. Our findings highlight the need of investigating sex and age differences in biological pathways that link inflammation and mortality.
•The age-related distribution of hs-CRP varied among men and women.•There was a linear association between hs-CRP and the hazard of all-cause death among men and women.•Elevated hs-CRP was associated with an increased risk of all-cause death in women and subjects aged below 65 years.•There is a need of investigating sex and age differences in the biological pathways that link inflammation and mortality.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>36967048</pmid><doi>10.1016/j.mad.2023.111804</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6447-6591</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0047-6374 |
| ispartof | Mechanisms of ageing and development, 2023-04, Vol.211, p.111804-111804, Article 111804 |
| issn | 0047-6374 1872-6216 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2791708049 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age All-cause death C-Reactive Protein - metabolism CVD death Female Gender Hs-CRP Humans Inflammation Male Proportional Hazards Models Prospective Studies Risk Factors |
| title | Sex and age differences in the association between high sensitivity C-reactive protein and all-cause mortality: A 12-year prospective cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T13%3A14%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex%20and%20age%20differences%20in%20the%20association%20between%20high%20sensitivity%20C-reactive%20protein%20and%20all-cause%20mortality:%20A%2012-year%20prospective%20cohort%20study&rft.jtitle=Mechanisms%20of%20ageing%20and%20development&rft.au=Bafei,%20Solim%20Essomandan%20Cl%C3%A9mence&rft.date=2023-04&rft.volume=211&rft.spage=111804&rft.epage=111804&rft.pages=111804-111804&rft.artnum=111804&rft.issn=0047-6374&rft.eissn=1872-6216&rft_id=info:doi/10.1016/j.mad.2023.111804&rft_dat=%3Cproquest_cross%3E2791708049%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2791708049&rft_id=info:pmid/36967048&rft_els_id=S0047637423000301&rfr_iscdi=true |