Development and evaluation of a mouse model susceptible to severe fever with thrombocytopenia syndrome virus by rAAV-based exogenous human DC-SIGN expression

Experimental animal model is indispensable to evaluate the prophylactic and therapeutic candidates against severe fever with thrombocytopenia syndrome virus (SFTSV). To develop a suitable mouse model for SFTSV infection, we delivered human dendritic cell–specific ICAM-3-grabbing non-integrin (hDC-SI...

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Veröffentlicht in:	Microbial pathogenesis 2023-05, Vol.178, p.106079-106079, Article 106079
Hauptverfasser:	Park, Ji-Young, Chandran, Sivasankar, Hewawaduge, Chamith, Lee, John Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal hDC-SIGN Humans Mice Mice model Mice, Inbred C57BL Phlebovirus - genetics Phlebovirus - metabolism rAAV Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Severe Fever with Thrombocytopenia Syndrome SFTSV Viral susceptibility
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