Norfloxacin Cocrystals: Mechanochemical Synthesis and Scale-up Viability Through Solubility Studies

•New norfloxacin cocrystals synthesized by a mechanochemical method.•The apparent aqueous solubility in the cocrystals is higher compared to pure drug.•Establishment of scale-up conditions from solution crystallization. Cocrystals are recognized as one of the most efficient approaches to improve aqu...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2023-08, Vol.112 (8), p.2230-2239
Hauptverfasser:	Ferreira, Patricia O., de Almeida, Amanda C., Costa, Giovanna de P., Torquetti, Carolina, Baptista, João A., Eusébio, M.Ermelinda S., Caires, Flavio J., Castro, Ricardo A.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cocrystal Mechanochemical synthesis Norfloxacin Scale-up Solubility studies Ternary phase diagram
Online-Zugang:	Volltext
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