TGF-β1 ameliorates BBB injury and improves long-term outcomes in mice after ICH

Intracerebral hemorrhage (ICH) is a devastating subtype of stroke characterized by high mortality and morbidity rates with no effective treatment. TGF-β/ALK-5 signaling is reported to participated in the regulation of blood-brain barrier (BBB) integrity in the inflammation pain model, the effects of...

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Veröffentlicht in:	Biochemical and biophysical research communications 2023-04, Vol.654, p.136-144
Hauptverfasser:	Wen, Huimei, Tan, Jiaying, Tian, Mi, Wang, Yao, Gao, Yanqin, Gong, Ye
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood-brain barrier Blood-Brain Barrier - metabolism Brain Edema - drug therapy Brain Edema - metabolism Cerebral Hemorrhage - drug therapy Cerebral Hemorrhage - metabolism Intracerebral hemorrhage Mice Microglia/macrophage Neuroinflammation Signal Transduction Stroke - metabolism TGF-β1 Transforming Growth Factor beta1 - metabolism
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