Relationship between molecular markers and lymphadenectomy and lymphovascular space invasion in endometrial cancer
Purpose Relationship between pathologic parameters, surgical parameters, or lymph node status with oncologic outcomes is not fully elucidated in endometrial cancer (EC). We want to investigate the molecular classification of uterine cancer in the Turkish population and its relationship between lymph...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2023-09, Vol.308 (3), p.941-946 |
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| creator | Bilir, Filiz Arıoz, Dagıstan Tolga Arıkan, Suna Evrim Yalcın, Gulsum Seyma Ozdemir, Cigdem Demir, Hacer Chkhikvadze, Mariam Ozdemir, Cem Yagmur Cicekli, Nayif Vatansever, Nefize Yılmaz, Sezgin |
| description | Purpose
Relationship between pathologic parameters, surgical parameters, or lymph node status with oncologic outcomes is not fully elucidated in endometrial cancer (EC). We want to investigate the molecular classification of uterine cancer in the Turkish population and its relationship between lymphadenectomy and lymph node metastasis.
Methods
In this study, 100 patients' clinical and pathologic data diagnosed with EC were analyzed. Pathologic and molecular parameters were investigated and compared them with clinical parameters.
Results
According to the molecular analysis, 16 patients (16%) had p53 mutation, 3 patients (3%) were classified as POLE mutant group, 38 (38%) patients in the MSI group, and the remaining 43 patients (43%) into the no specific mutation profile (NSMP) group. Lymph node metastasis rate was significantly higher in copy number high (CNH) group compared to the others. In the CNH group, 29 of 437 (6.6%) dissected lymph nodes had metastasis. The median OS was the highest in the POLE group (72 months) and lowest in the CNH group (36 months).
Conclusion
Endometrial cancer patients showed significantly different overall and disease-free survival according to the molecular subtypes and it was consistent with the literature, Lymph node metastasis risk was the highest in CNH group. MSI status is important for the lymph node metastasis risk but not all abnormalities, especially PMS2 and MLH1 expression changes showed the highest risk. |
| doi_str_mv | 10.1007/s00404-023-07005-9 |
| format | Article |
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Relationship between pathologic parameters, surgical parameters, or lymph node status with oncologic outcomes is not fully elucidated in endometrial cancer (EC). We want to investigate the molecular classification of uterine cancer in the Turkish population and its relationship between lymphadenectomy and lymph node metastasis.
Methods
In this study, 100 patients' clinical and pathologic data diagnosed with EC were analyzed. Pathologic and molecular parameters were investigated and compared them with clinical parameters.
Results
According to the molecular analysis, 16 patients (16%) had p53 mutation, 3 patients (3%) were classified as POLE mutant group, 38 (38%) patients in the MSI group, and the remaining 43 patients (43%) into the no specific mutation profile (NSMP) group. Lymph node metastasis rate was significantly higher in copy number high (CNH) group compared to the others. In the CNH group, 29 of 437 (6.6%) dissected lymph nodes had metastasis. The median OS was the highest in the POLE group (72 months) and lowest in the CNH group (36 months).
Conclusion
Endometrial cancer patients showed significantly different overall and disease-free survival according to the molecular subtypes and it was consistent with the literature, Lymph node metastasis risk was the highest in CNH group. MSI status is important for the lymph node metastasis risk but not all abnormalities, especially PMS2 and MLH1 expression changes showed the highest risk.</description><identifier>ISSN: 1432-0711</identifier><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-023-07005-9</identifier><identifier>PMID: 36959366</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Endocrinology ; Endometrial cancer ; Gynecologic Oncology ; Gynecology ; Human Genetics ; Lymphatic system ; Medicine ; Medicine & Public Health ; Metastasis ; Obstetrics/Perinatology/Midwifery ; Uterine cancer</subject><ispartof>Archives of gynecology and obstetrics, 2023-09, Vol.308 (3), p.941-946</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-b961f5e0998dd55868a690c7c08d28b0f6251463ae4c5c416686eb3d252a4f073</citedby><cites>FETCH-LOGICAL-c375t-b961f5e0998dd55868a690c7c08d28b0f6251463ae4c5c416686eb3d252a4f073</cites><orcidid>0000-0003-3616-0789 ; 0000-0003-1235-9363 ; 0000-0002-8550-793X ; 0000-0002-8961-1304</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-023-07005-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-023-07005-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36959366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bilir, Filiz</creatorcontrib><creatorcontrib>Arıoz, Dagıstan Tolga</creatorcontrib><creatorcontrib>Arıkan, Suna Evrim</creatorcontrib><creatorcontrib>Yalcın, Gulsum Seyma</creatorcontrib><creatorcontrib>Ozdemir, Cigdem</creatorcontrib><creatorcontrib>Demir, Hacer</creatorcontrib><creatorcontrib>Chkhikvadze, Mariam</creatorcontrib><creatorcontrib>Ozdemir, Cem Yagmur</creatorcontrib><creatorcontrib>Cicekli, Nayif</creatorcontrib><creatorcontrib>Vatansever, Nefize</creatorcontrib><creatorcontrib>Yılmaz, Sezgin</creatorcontrib><title>Relationship between molecular markers and lymphadenectomy and lymphovascular space invasion in endometrial cancer</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
Relationship between pathologic parameters, surgical parameters, or lymph node status with oncologic outcomes is not fully elucidated in endometrial cancer (EC). We want to investigate the molecular classification of uterine cancer in the Turkish population and its relationship between lymphadenectomy and lymph node metastasis.
Methods
In this study, 100 patients' clinical and pathologic data diagnosed with EC were analyzed. Pathologic and molecular parameters were investigated and compared them with clinical parameters.
Results
According to the molecular analysis, 16 patients (16%) had p53 mutation, 3 patients (3%) were classified as POLE mutant group, 38 (38%) patients in the MSI group, and the remaining 43 patients (43%) into the no specific mutation profile (NSMP) group. Lymph node metastasis rate was significantly higher in copy number high (CNH) group compared to the others. In the CNH group, 29 of 437 (6.6%) dissected lymph nodes had metastasis. The median OS was the highest in the POLE group (72 months) and lowest in the CNH group (36 months).
Conclusion
Endometrial cancer patients showed significantly different overall and disease-free survival according to the molecular subtypes and it was consistent with the literature, Lymph node metastasis risk was the highest in CNH group. MSI status is important for the lymph node metastasis risk but not all abnormalities, especially PMS2 and MLH1 expression changes showed the highest risk.</description><subject>Endocrinology</subject><subject>Endometrial cancer</subject><subject>Gynecologic Oncology</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Lymphatic system</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Uterine cancer</subject><issn>1432-0711</issn><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kctu1jAQRi0Eohd4ARYoEptuQsfX2EtU9YJUCamCteU4E5qS2KmdtPrfHrcptGLByuPxmc-WDyEfKHymAM1xBhAgamC8hgZA1uYV2aeCs7Kl9PWLeo8c5HwDQJnW6i3Z48pIw5XaJ-kKR7cMMeTrYa5aXO4RQzXFEf06ulRNLv3ClCsXumrcTfO16zCgX-K0e-7FO5c3PM_OYzWE0iiZpagwdHHCJQ1urLwLHtM78qZ3Y8b3T-sh-XF2-v3kor78dv715Mtl7Xkjl7o1ivYSwRjddVJqpZ0y4BsPumO6hV4xSYXiDoWXXlCltMKWd0wyJ3po-CE52nLnFG9XzIudhuxxHF3AuGbLGkN5Q40WBf30D3oT1xTK6yzTvGGgmTCFYhvlU8w5YW_nNJQP2lkK9sGI3YzYYsQ-GrEPQx-fotd2wu7vyB8FBeAbkMtR-Inp-e7_xP4GZw6Xqg</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Bilir, Filiz</creator><creator>Arıoz, Dagıstan Tolga</creator><creator>Arıkan, Suna Evrim</creator><creator>Yalcın, Gulsum Seyma</creator><creator>Ozdemir, Cigdem</creator><creator>Demir, Hacer</creator><creator>Chkhikvadze, Mariam</creator><creator>Ozdemir, Cem Yagmur</creator><creator>Cicekli, Nayif</creator><creator>Vatansever, Nefize</creator><creator>Yılmaz, Sezgin</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3616-0789</orcidid><orcidid>https://orcid.org/0000-0003-1235-9363</orcidid><orcidid>https://orcid.org/0000-0002-8550-793X</orcidid><orcidid>https://orcid.org/0000-0002-8961-1304</orcidid></search><sort><creationdate>20230901</creationdate><title>Relationship between molecular markers and lymphadenectomy and lymphovascular space invasion in endometrial cancer</title><author>Bilir, Filiz ; Arıoz, Dagıstan Tolga ; Arıkan, Suna Evrim ; Yalcın, Gulsum Seyma ; Ozdemir, Cigdem ; Demir, Hacer ; Chkhikvadze, Mariam ; Ozdemir, Cem Yagmur ; Cicekli, Nayif ; Vatansever, Nefize ; Yılmaz, Sezgin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-b961f5e0998dd55868a690c7c08d28b0f6251463ae4c5c416686eb3d252a4f073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Endocrinology</topic><topic>Endometrial cancer</topic><topic>Gynecologic Oncology</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Lymphatic system</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Uterine cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bilir, Filiz</creatorcontrib><creatorcontrib>Arıoz, Dagıstan Tolga</creatorcontrib><creatorcontrib>Arıkan, Suna Evrim</creatorcontrib><creatorcontrib>Yalcın, Gulsum Seyma</creatorcontrib><creatorcontrib>Ozdemir, Cigdem</creatorcontrib><creatorcontrib>Demir, Hacer</creatorcontrib><creatorcontrib>Chkhikvadze, Mariam</creatorcontrib><creatorcontrib>Ozdemir, Cem Yagmur</creatorcontrib><creatorcontrib>Cicekli, Nayif</creatorcontrib><creatorcontrib>Vatansever, Nefize</creatorcontrib><creatorcontrib>Yılmaz, Sezgin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bilir, Filiz</au><au>Arıoz, Dagıstan Tolga</au><au>Arıkan, Suna Evrim</au><au>Yalcın, Gulsum Seyma</au><au>Ozdemir, Cigdem</au><au>Demir, Hacer</au><au>Chkhikvadze, Mariam</au><au>Ozdemir, Cem Yagmur</au><au>Cicekli, Nayif</au><au>Vatansever, Nefize</au><au>Yılmaz, Sezgin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between molecular markers and lymphadenectomy and lymphovascular space invasion in endometrial cancer</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>308</volume><issue>3</issue><spage>941</spage><epage>946</epage><pages>941-946</pages><issn>1432-0711</issn><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
Relationship between pathologic parameters, surgical parameters, or lymph node status with oncologic outcomes is not fully elucidated in endometrial cancer (EC). We want to investigate the molecular classification of uterine cancer in the Turkish population and its relationship between lymphadenectomy and lymph node metastasis.
Methods
In this study, 100 patients' clinical and pathologic data diagnosed with EC were analyzed. Pathologic and molecular parameters were investigated and compared them with clinical parameters.
Results
According to the molecular analysis, 16 patients (16%) had p53 mutation, 3 patients (3%) were classified as POLE mutant group, 38 (38%) patients in the MSI group, and the remaining 43 patients (43%) into the no specific mutation profile (NSMP) group. Lymph node metastasis rate was significantly higher in copy number high (CNH) group compared to the others. In the CNH group, 29 of 437 (6.6%) dissected lymph nodes had metastasis. The median OS was the highest in the POLE group (72 months) and lowest in the CNH group (36 months).
Conclusion
Endometrial cancer patients showed significantly different overall and disease-free survival according to the molecular subtypes and it was consistent with the literature, Lymph node metastasis risk was the highest in CNH group. MSI status is important for the lymph node metastasis risk but not all abnormalities, especially PMS2 and MLH1 expression changes showed the highest risk.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36959366</pmid><doi>10.1007/s00404-023-07005-9</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3616-0789</orcidid><orcidid>https://orcid.org/0000-0003-1235-9363</orcidid><orcidid>https://orcid.org/0000-0002-8550-793X</orcidid><orcidid>https://orcid.org/0000-0002-8961-1304</orcidid></addata></record> |
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| ispartof | Archives of gynecology and obstetrics, 2023-09, Vol.308 (3), p.941-946 |
| issn | 1432-0711 0932-0067 1432-0711 |
| language | eng |
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| source | SpringerLink Journals |
| subjects | Endocrinology Endometrial cancer Gynecologic Oncology Gynecology Human Genetics Lymphatic system Medicine Medicine & Public Health Metastasis Obstetrics/Perinatology/Midwifery Uterine cancer |
| title | Relationship between molecular markers and lymphadenectomy and lymphovascular space invasion in endometrial cancer |
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