Fate-mapping antibodies to study sinful immune dynamics

Antibody dynamics resulting from sequential immunization are complex, limiting the study of concepts such as ‘original antigenic sin’. Here, molecular fate-mapping defines an ‘addiction’ of boosted antibodies to primary clones, and OAS-like suppression of new clones, to a degree inversely related to...

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Veröffentlicht in:	Nature immunology 2023-04, Vol.24 (4), p.570-572
Hauptverfasser:	McGrath, Joshua J. C., Wilson, Patrick C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2152/2153/1291 631/250/2152/2153/1571 Addictions Antibodies Antigens Bias Biomedical and Life Sciences Biomedicine Cloning Immunization Immunology Infections Infectious Diseases Influenza Mapping Medical research News & Views news-and-views Pathogens Severe acute respiratory syndrome coronavirus 2 Vaccines
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Beschreibung
Zusammenfassung:	Antibody dynamics resulting from sequential immunization are complex, limiting the study of concepts such as ‘original antigenic sin’. Here, molecular fate-mapping defines an ‘addiction’ of boosted antibodies to primary clones, and OAS-like suppression of new clones, to a degree inversely related to boosting antigenic distance.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/s41590-023-01467-4