Circulating tumor HPV DNA as an alternative method to determine HPV status in oropharyngeal squamous cell carcinoma
•ctHPVDNA can effectively confirm HPV-status.•ctHPVDNA may replace additional biopsies in patients with indeterminate FNA results.•A wider application of ctHPVDNA may allow for improved diagnostics. Human Papilloma Virus (HPV) testing is mandatory for all newly diagnosed oropharyngeal squamous cell...
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| Veröffentlicht in: | Oral oncology 2023-05, Vol.140, p.106361-106361, Article 106361 |
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| container_title | Oral oncology |
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| creator | Lambert, Todd Tasoulas, Jason Flores, Melissa Sheth, Siddharth Patel, Samip N. |
| description | •ctHPVDNA can effectively confirm HPV-status.•ctHPVDNA may replace additional biopsies in patients with indeterminate FNA results.•A wider application of ctHPVDNA may allow for improved diagnostics.
Human Papilloma Virus (HPV) testing is mandatory for all newly diagnosed oropharyngeal squamous cell carcinoma (OPSCC) due to its importance for prognostication and aiding in treatment decision making. Fine needle aspiration (FNA) is a widely used and accepted diagnostic tool for OPSCC. Although FNA can accurately determine histological diagnosis, results are often indeterminate or lack insufficient samples for HPV testing. For samples with an indeterminant FNA, we propose an alternate method for determining HPV status using circulating tumor tissue modified HPV DNA (ctHPVDNA). We report three cases that confirmed HPV status using ctHPVDNA following an indeterminate FNA. If validated, this non-invasive assay could prevent the need for repeat FNAs or operative biopsies for the sole purpose of determining HPV status. |
| doi_str_mv | 10.1016/j.oraloncology.2023.106361 |
| format | Article |
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Human Papilloma Virus (HPV) testing is mandatory for all newly diagnosed oropharyngeal squamous cell carcinoma (OPSCC) due to its importance for prognostication and aiding in treatment decision making. Fine needle aspiration (FNA) is a widely used and accepted diagnostic tool for OPSCC. Although FNA can accurately determine histological diagnosis, results are often indeterminate or lack insufficient samples for HPV testing. For samples with an indeterminant FNA, we propose an alternate method for determining HPV status using circulating tumor tissue modified HPV DNA (ctHPVDNA). We report three cases that confirmed HPV status using ctHPVDNA following an indeterminate FNA. If validated, this non-invasive assay could prevent the need for repeat FNAs or operative biopsies for the sole purpose of determining HPV status.</description><identifier>ISSN: 1368-8375</identifier><identifier>EISSN: 1879-0593</identifier><identifier>DOI: 10.1016/j.oraloncology.2023.106361</identifier><identifier>PMID: 36965412</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Biopsy, Fine-Needle - methods ; ctHPVDNA ; FNA ; Head and Neck Neoplasms ; HPV ; Humans ; Liquid Biopsy ; NavDx ; Oropharyngeal Neoplasms ; Oropharyngeal squamous cell carcinoma ; Papillomaviridae - genetics ; Papillomavirus Infections - complications ; Papillomavirus Infections - diagnosis ; Squamous Cell Carcinoma of Head and Neck</subject><ispartof>Oral oncology, 2023-05, Vol.140, p.106361-106361, Article 106361</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-f88715899fe41b17a824ac4ccb0a7c6fb5151ecfae56478bcef16c9ca0cd00633</citedby><cites>FETCH-LOGICAL-c380t-f88715899fe41b17a824ac4ccb0a7c6fb5151ecfae56478bcef16c9ca0cd00633</cites><orcidid>0000-0002-1923-2309</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1368837523000568$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36965412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lambert, Todd</creatorcontrib><creatorcontrib>Tasoulas, Jason</creatorcontrib><creatorcontrib>Flores, Melissa</creatorcontrib><creatorcontrib>Sheth, Siddharth</creatorcontrib><creatorcontrib>Patel, Samip N.</creatorcontrib><title>Circulating tumor HPV DNA as an alternative method to determine HPV status in oropharyngeal squamous cell carcinoma</title><title>Oral oncology</title><addtitle>Oral Oncol</addtitle><description>•ctHPVDNA can effectively confirm HPV-status.•ctHPVDNA may replace additional biopsies in patients with indeterminate FNA results.•A wider application of ctHPVDNA may allow for improved diagnostics.
Human Papilloma Virus (HPV) testing is mandatory for all newly diagnosed oropharyngeal squamous cell carcinoma (OPSCC) due to its importance for prognostication and aiding in treatment decision making. Fine needle aspiration (FNA) is a widely used and accepted diagnostic tool for OPSCC. Although FNA can accurately determine histological diagnosis, results are often indeterminate or lack insufficient samples for HPV testing. For samples with an indeterminant FNA, we propose an alternate method for determining HPV status using circulating tumor tissue modified HPV DNA (ctHPVDNA). We report three cases that confirmed HPV status using ctHPVDNA following an indeterminate FNA. If validated, this non-invasive assay could prevent the need for repeat FNAs or operative biopsies for the sole purpose of determining HPV status.</description><subject>Biopsy, Fine-Needle - methods</subject><subject>ctHPVDNA</subject><subject>FNA</subject><subject>Head and Neck Neoplasms</subject><subject>HPV</subject><subject>Humans</subject><subject>Liquid Biopsy</subject><subject>NavDx</subject><subject>Oropharyngeal Neoplasms</subject><subject>Oropharyngeal squamous cell carcinoma</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - diagnosis</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><issn>1368-8375</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFv1DAQhS0EoqXwF5DFiUsWO4kdh1u1BYpUAQfgak0mk61Xib21nUr993jZgjhyGmveG8-8j7E3UmykkPrdfhMizMFjmMPuYVOLuimCbrR8ws6l6fpKqL55Wt6NNpVpOnXGXqS0F0IoqcRzdtboXqtW1ucsbV3EdYbs_I7ndQmRX3_7ya--XHJIHDyHOVP0Rb8nvlC-DSPPgY9Uuovz9NudMuQ1ced5iOFwC_HB7whmnu5WWEJRkOaZI0R0Pizwkj2bYE706rFesB8fP3zfXlc3Xz993l7eVNgYkavJmE4q0_cTtXKQHZi6BWwRBwEd6mkoYSThBKR025kBaZIaewSBoyg4mgv29vTvIYa7lVK2i0vHU8BTucrWXV8I9apWxfr-ZMUYUoo02UN0SwlipbBH6HZv_4Vuj9DtCXoZfv24Zx0WGv-O_qFcDFcnA5W0946iTejII40uEmY7Bvc_e34BW5mcPg</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Lambert, Todd</creator><creator>Tasoulas, Jason</creator><creator>Flores, Melissa</creator><creator>Sheth, Siddharth</creator><creator>Patel, Samip N.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1923-2309</orcidid></search><sort><creationdate>202305</creationdate><title>Circulating tumor HPV DNA as an alternative method to determine HPV status in oropharyngeal squamous cell carcinoma</title><author>Lambert, Todd ; Tasoulas, Jason ; Flores, Melissa ; Sheth, Siddharth ; Patel, Samip N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-f88715899fe41b17a824ac4ccb0a7c6fb5151ecfae56478bcef16c9ca0cd00633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biopsy, Fine-Needle - methods</topic><topic>ctHPVDNA</topic><topic>FNA</topic><topic>Head and Neck Neoplasms</topic><topic>HPV</topic><topic>Humans</topic><topic>Liquid Biopsy</topic><topic>NavDx</topic><topic>Oropharyngeal Neoplasms</topic><topic>Oropharyngeal squamous cell carcinoma</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - diagnosis</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lambert, Todd</creatorcontrib><creatorcontrib>Tasoulas, Jason</creatorcontrib><creatorcontrib>Flores, Melissa</creatorcontrib><creatorcontrib>Sheth, Siddharth</creatorcontrib><creatorcontrib>Patel, Samip N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lambert, Todd</au><au>Tasoulas, Jason</au><au>Flores, Melissa</au><au>Sheth, Siddharth</au><au>Patel, Samip N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating tumor HPV DNA as an alternative method to determine HPV status in oropharyngeal squamous cell carcinoma</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2023-05</date><risdate>2023</risdate><volume>140</volume><spage>106361</spage><epage>106361</epage><pages>106361-106361</pages><artnum>106361</artnum><issn>1368-8375</issn><eissn>1879-0593</eissn><abstract>•ctHPVDNA can effectively confirm HPV-status.•ctHPVDNA may replace additional biopsies in patients with indeterminate FNA results.•A wider application of ctHPVDNA may allow for improved diagnostics.
Human Papilloma Virus (HPV) testing is mandatory for all newly diagnosed oropharyngeal squamous cell carcinoma (OPSCC) due to its importance for prognostication and aiding in treatment decision making. Fine needle aspiration (FNA) is a widely used and accepted diagnostic tool for OPSCC. Although FNA can accurately determine histological diagnosis, results are often indeterminate or lack insufficient samples for HPV testing. For samples with an indeterminant FNA, we propose an alternate method for determining HPV status using circulating tumor tissue modified HPV DNA (ctHPVDNA). We report three cases that confirmed HPV status using ctHPVDNA following an indeterminate FNA. If validated, this non-invasive assay could prevent the need for repeat FNAs or operative biopsies for the sole purpose of determining HPV status.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36965412</pmid><doi>10.1016/j.oraloncology.2023.106361</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1923-2309</orcidid></addata></record> |
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| identifier | ISSN: 1368-8375 |
| ispartof | Oral oncology, 2023-05, Vol.140, p.106361-106361, Article 106361 |
| issn | 1368-8375 1879-0593 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biopsy, Fine-Needle - methods ctHPVDNA FNA Head and Neck Neoplasms HPV Humans Liquid Biopsy NavDx Oropharyngeal Neoplasms Oropharyngeal squamous cell carcinoma Papillomaviridae - genetics Papillomavirus Infections - complications Papillomavirus Infections - diagnosis Squamous Cell Carcinoma of Head and Neck |
| title | Circulating tumor HPV DNA as an alternative method to determine HPV status in oropharyngeal squamous cell carcinoma |
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