A novel role for YPEL2 in mediating endothelial cellular senescence via the p53/p21 pathway

Yippee-like 2 (YPEL2) is expressed in tissues and organs enriched in vascular networks, such as heart, kidney, and lung. However, the roles of YPEL2 in endothelial cell senescence and the expression of YPEL2 in atherosclerotic plaques have not yet been investigated. Here, we report the essential rol...

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Veröffentlicht in:	Mechanisms of ageing and development 2023-04, Vol.211, p.111803-111803, Article 111803
Hauptverfasser:	Xu, Jian-Xiong, Tang, Mao-Lin, Lu, Zhi-Feng, Song, Yu, Zhang, Ke-Lan, He, Run-Chao, Guo, Xiang-Na, Yuan, Yun-Qi, Dai, Xiaoyan, Ma, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis Cell Cycle Proteins - metabolism Cellular Senescence Endothelial cell Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - metabolism Humans Hydrogen Peroxide Mice P53 Plaque, Atherosclerotic - metabolism Senescence Tumor Suppressor Protein p53 - metabolism YPEL2
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