Mussel-Inspired Multifunctional Hydrogels with Adhesive, Self-Healing, Antioxidative, and Antibacterial Activity for Wound Healing
Antibacterial hydrogel wound dressings with adhesive and antioxidant activity are desirable for treating skin injuries in clinical care. Hereby, a series of multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated...
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| Veröffentlicht in: | ACS applied materials & interfaces 2023-04, Vol.15 (13), p.16515-16525 |
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| container_title | ACS applied materials & interfaces |
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| creator | Wang, Lanlan Zhao, Ziqiang Dong, Jinhua Li, Dawei Dong, Wenhao Li, Haoxuan Zhou, Yuqi Liu, Qingsheng Deng, Bingyao |
| description | Antibacterial hydrogel wound dressings with adhesive and antioxidant activity are desirable for treating skin injuries in clinical care. Hereby, a series of multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated using dopamine (DA) and quercetin (QT). The multifunctional hydrogels were constructed by the interpenetrated quaternized chitosan chain segments and polyacrylamide network. The catechol groups on DA, QT, and the quaternary ammonium groups in the hydrogel system endow hydrogels with high strength, excellent adhesion, and self-healing ability. The results confirmed the admirable hemocompatibility and remarkable antibacterial activity of the multifunction hydrogels against Staphylococcus aureus and Escherichia coli. Consequently, multifunction hydrogels with satisfactory adhesive and antibacterial activity are appropriate alternative materials in the fields of tissue adhesive and wound dressing applications. |
| doi_str_mv | 10.1021/acsami.3c01065 |
| format | Article |
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Hereby, a series of multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated using dopamine (DA) and quercetin (QT). The multifunctional hydrogels were constructed by the interpenetrated quaternized chitosan chain segments and polyacrylamide network. The catechol groups on DA, QT, and the quaternary ammonium groups in the hydrogel system endow hydrogels with high strength, excellent adhesion, and self-healing ability. The results confirmed the admirable hemocompatibility and remarkable antibacterial activity of the multifunction hydrogels against Staphylococcus aureus and Escherichia coli. Consequently, multifunction hydrogels with satisfactory adhesive and antibacterial activity are appropriate alternative materials in the fields of tissue adhesive and wound dressing applications.</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.3c01065</identifier><identifier>PMID: 36951622</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Adhesives ; Anti-Bacterial Agents ; Antioxidants ; Biological and Medical Applications of Materials and Interfaces ; Chitosan ; Hydrogels ; Quercetin ; Wound Healing</subject><ispartof>ACS applied materials & interfaces, 2023-04, Vol.15 (13), p.16515-16525</ispartof><rights>2023 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a330t-d8eb20cab9664c328de547216802fd47f02acf802066dc38139fd68f75b56ef33</citedby><cites>FETCH-LOGICAL-a330t-d8eb20cab9664c328de547216802fd47f02acf802066dc38139fd68f75b56ef33</cites><orcidid>0000-0003-3903-7364 ; 0000-0003-2721-4618 ; 0000-0001-5652-3503</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsami.3c01065$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsami.3c01065$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,781,785,2766,27081,27929,27930,56743,56793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36951622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Lanlan</creatorcontrib><creatorcontrib>Zhao, Ziqiang</creatorcontrib><creatorcontrib>Dong, Jinhua</creatorcontrib><creatorcontrib>Li, Dawei</creatorcontrib><creatorcontrib>Dong, Wenhao</creatorcontrib><creatorcontrib>Li, Haoxuan</creatorcontrib><creatorcontrib>Zhou, Yuqi</creatorcontrib><creatorcontrib>Liu, Qingsheng</creatorcontrib><creatorcontrib>Deng, Bingyao</creatorcontrib><title>Mussel-Inspired Multifunctional Hydrogels with Adhesive, Self-Healing, Antioxidative, and Antibacterial Activity for Wound Healing</title><title>ACS applied materials & interfaces</title><addtitle>ACS Appl. Mater. Interfaces</addtitle><description>Antibacterial hydrogel wound dressings with adhesive and antioxidant activity are desirable for treating skin injuries in clinical care. Hereby, a series of multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated using dopamine (DA) and quercetin (QT). The multifunctional hydrogels were constructed by the interpenetrated quaternized chitosan chain segments and polyacrylamide network. The catechol groups on DA, QT, and the quaternary ammonium groups in the hydrogel system endow hydrogels with high strength, excellent adhesion, and self-healing ability. The results confirmed the admirable hemocompatibility and remarkable antibacterial activity of the multifunction hydrogels against Staphylococcus aureus and Escherichia coli. Consequently, multifunction hydrogels with satisfactory adhesive and antibacterial activity are appropriate alternative materials in the fields of tissue adhesive and wound dressing applications.</description><subject>Adhesives</subject><subject>Anti-Bacterial Agents</subject><subject>Antioxidants</subject><subject>Biological and Medical Applications of Materials and Interfaces</subject><subject>Chitosan</subject><subject>Hydrogels</subject><subject>Quercetin</subject><subject>Wound Healing</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0E4lFYGVFGhJriR-IkY4SAVmrFAIgxcuzr1shNip0AXfnlmLawMV3f6_Od4UPonOARwZRcC-nF0oyYxATzdA8dkyJJ4pymdP_vnSRH6MT7V4w5ozg9REeMFynhlB6jr1nvPdh40viVcaCiWW87o_tGdqZthI3Ga-XaOVgffZhuEZVqAd68wzB6BKvjMQhrmvkwKpvAfxolus2naNTmVAvZgTPBUwbhu-nWkW5d9NL2AdiFT9GBFtbD2W4O0PPd7dPNOJ4-3E9uymksGMNdrHKoKZaiLjhPJKO5gjTJKOE5plolmcZUSB0WzLmSLCes0IrnOkvrlINmbIAut96Va9968F21NF6CtaKBtvcVzQqMU8wpD-hoi0rXeu9AVytnlsKtK4Krn96rbe_VrvcQuNi5-3oJ6g__LToAV1sgBKvXtnehW_-f7RvjJ47i</recordid><startdate>20230405</startdate><enddate>20230405</enddate><creator>Wang, Lanlan</creator><creator>Zhao, Ziqiang</creator><creator>Dong, Jinhua</creator><creator>Li, Dawei</creator><creator>Dong, Wenhao</creator><creator>Li, Haoxuan</creator><creator>Zhou, Yuqi</creator><creator>Liu, Qingsheng</creator><creator>Deng, Bingyao</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3903-7364</orcidid><orcidid>https://orcid.org/0000-0003-2721-4618</orcidid><orcidid>https://orcid.org/0000-0001-5652-3503</orcidid></search><sort><creationdate>20230405</creationdate><title>Mussel-Inspired Multifunctional Hydrogels with Adhesive, Self-Healing, Antioxidative, and Antibacterial Activity for Wound Healing</title><author>Wang, Lanlan ; Zhao, Ziqiang ; Dong, Jinhua ; Li, Dawei ; Dong, Wenhao ; Li, Haoxuan ; Zhou, Yuqi ; Liu, Qingsheng ; Deng, Bingyao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a330t-d8eb20cab9664c328de547216802fd47f02acf802066dc38139fd68f75b56ef33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adhesives</topic><topic>Anti-Bacterial Agents</topic><topic>Antioxidants</topic><topic>Biological and Medical Applications of Materials and Interfaces</topic><topic>Chitosan</topic><topic>Hydrogels</topic><topic>Quercetin</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Lanlan</creatorcontrib><creatorcontrib>Zhao, Ziqiang</creatorcontrib><creatorcontrib>Dong, Jinhua</creatorcontrib><creatorcontrib>Li, Dawei</creatorcontrib><creatorcontrib>Dong, Wenhao</creatorcontrib><creatorcontrib>Li, Haoxuan</creatorcontrib><creatorcontrib>Zhou, Yuqi</creatorcontrib><creatorcontrib>Liu, Qingsheng</creatorcontrib><creatorcontrib>Deng, Bingyao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Lanlan</au><au>Zhao, Ziqiang</au><au>Dong, Jinhua</au><au>Li, Dawei</au><au>Dong, Wenhao</au><au>Li, Haoxuan</au><au>Zhou, Yuqi</au><au>Liu, Qingsheng</au><au>Deng, Bingyao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mussel-Inspired Multifunctional Hydrogels with Adhesive, Self-Healing, Antioxidative, and Antibacterial Activity for Wound Healing</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2023-04-05</date><risdate>2023</risdate><volume>15</volume><issue>13</issue><spage>16515</spage><epage>16525</epage><pages>16515-16525</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>Antibacterial hydrogel wound dressings with adhesive and antioxidant activity are desirable for treating skin injuries in clinical care. Hereby, a series of multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated using dopamine (DA) and quercetin (QT). The multifunctional hydrogels were constructed by the interpenetrated quaternized chitosan chain segments and polyacrylamide network. The catechol groups on DA, QT, and the quaternary ammonium groups in the hydrogel system endow hydrogels with high strength, excellent adhesion, and self-healing ability. The results confirmed the admirable hemocompatibility and remarkable antibacterial activity of the multifunction hydrogels against Staphylococcus aureus and Escherichia coli. Consequently, multifunction hydrogels with satisfactory adhesive and antibacterial activity are appropriate alternative materials in the fields of tissue adhesive and wound dressing applications.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>36951622</pmid><doi>10.1021/acsami.3c01065</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3903-7364</orcidid><orcidid>https://orcid.org/0000-0003-2721-4618</orcidid><orcidid>https://orcid.org/0000-0001-5652-3503</orcidid></addata></record> |
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| subjects | Adhesives Anti-Bacterial Agents Antioxidants Biological and Medical Applications of Materials and Interfaces Chitosan Hydrogels Quercetin Wound Healing |
| title | Mussel-Inspired Multifunctional Hydrogels with Adhesive, Self-Healing, Antioxidative, and Antibacterial Activity for Wound Healing |
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