CRISPR-Cas-Driven Single Micromotor (Cas-DSM) Enables Direct Detection of Nucleic Acid Biomarkers at the Single-Molecule Level

The target-dependent endonuclease activity (also known as the trans-cleavage activity) of CRISPR-Cas systems has stimulated great interest in the development of nascent sensing strategies for nucleic acid diagnostics. Despite many attempts, the majority of the sensitive CRISPR-Cas diagnostics strate...

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Veröffentlicht in:	Analytical chemistry (Washington) 2023-04, Vol.95 (13), p.5729-5737
Hauptverfasser:	Chen, Desheng, Liang, Yuanwen, Wang, Honghong, Wang, Hui, Su, Fengxia, Zhang, Pengbo, Wang, Shuhui, Liu, Weiliang, Li, Zhengping
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Biomarkers Biosensing Techniques Chemistry CRISPR CRISPR-Cas Systems - genetics DNA Primers DNA probes Endonuclease Micromotors Nucleic Acids RNA Target detection
Online-Zugang:	Volltext
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