N-glycan in the variable region of monoclonal ACPA (CCP-Ab1) promotes the exacerbation of experimental arthritis

Abstract Objectives The variable region of most ACPA IgG molecules in the serum of RA patients carries N-glycan (N-glycanV). To analyse the pathogenicity of N-glycanV of ACPAs, we analysed the pathogenicity of a monoclonal ACPA, CCP-Ab1, with or without N-glycanV, which had been isolated from a pati...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2023-12, Vol.62 (12), p.3968-3977
Hauptverfasser:	Kawataka, Masatoshi, Ouhara, Kazuhisa, Kobayashi, Eiji, Shinoda, Koichiro, Tobe, Kazuyuki, Fujimori, Ryousuke, Mizuno, Noriyoshi, Sugiyama, Eiji, Ozawa, Tatsuhiko, Kishi, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminosalicylic Acids Animals Arthritis, Experimental Arthritis, Rheumatoid Autoantibodies Bone Resorption Humans Mice Myeloblastin Peptides, Cyclic Polysaccharides - metabolism
Online-Zugang:	Volltext
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