Clonal haematopoiesis and dysregulation of the immune system

Age-related diseases are frequently linked to pathological immune dysfunction, including excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human genetic data have revealed that somatic mutations and mosaic chromosomal alterations in blood cells — a condition known as cl...

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Veröffentlicht in:	Nature reviews. Immunology 2023-09, Vol.23 (9), p.595-610
Hauptverfasser:	Belizaire, Roger, Wong, Waihay J., Robinette, Michelle L., Ebert, Benjamin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/232 631/250/256 631/67/1990 Aging Animal models Animals Autoimmune diseases Autoimmunity Biomedical and Life Sciences Biomedicine Blood cancer Blood cells Cardiovascular diseases Chemokines Chronic obstructive pulmonary disease Clonal Hematopoiesis Disease DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methyltransferase 3A Epidemiology Epigenetics Genetic analysis Gout Hematopoiesis - genetics Hemopoiesis Humans Immune System Immunodeficiency Immunology Immunomodulation Inflammasomes Liver diseases Lung diseases Lymphoid cells Mice Mutation Myeloid cells Obstructive lung disease Osteoporosis Review Article
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