Impact of cisplatin-induced acute kidney injury on long-term renal function in patients with solid tumors
Background The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the incidence and risk factors for CIA development, and if CIA is a useful predictor of long-term renal dysfunction after cisplat...
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| Veröffentlicht in: | Clinical and experimental nephrology 2023-06, Vol.27 (6), p.506-518 |
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| container_title | Clinical and experimental nephrology |
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| creator | Hino, Amiko Muto, Satoru Shimada, Yosuke Hori, Satoshi Isotani, Shuji Nagata, Masayoshi Horie, Shigeo |
| description | Background
The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the incidence and risk factors for CIA development, and if CIA is a useful predictor of long-term renal dysfunction after cisplatin treatment.
Methods
This was a retrospective, single-center, observational, longitudinal follow-up, large cohort study in adult patients with solid tumors treated with cisplatin-based systematic chemotherapy. Electronic medical records were used for all demographic and medical data. AKI was defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria. We assessed long-term renal dysfunction using %ΔeGFR/Y; (the last eGFR value during follow-up)—(the baseline eGFR)/(the baseline eGFR)/year of follow-up × 100.
Results
A total of 2191 patients received 8,482 cycles of cisplatin. CIA was observed 359 times (4.2%). Significant risk factors for developing CIA, using multiple linear regression analysis, included: cisplatin administration immediately before the onset of CIA (
p
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| doi_str_mv | 10.1007/s10157-023-02324-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2789233784</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2789233784</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-8deb2b059cf228bf58e419105533a76e57ac6ca098df3f91a5acb1ab9ac294c43</originalsourceid><addsrcrecordid>eNp9kLtOwzAUhi0EglJ4AQbkkcXgS1zHI6q4SUgsMFuO4xSXxA6-CPXtSWlhZDg6R_q_8w8fABcEXxOMxU0imHCBMGXboRWiB2BGKiaQEFIeTjerKCKCkxNwmtIaY1xLLo_BCVvIinCMZ8A9DaM2GYYOGpfGXmfnkfNtMbaF2pRs4Ydrvd1A59clbmDwsA9-hbKNA4zW6x52xZvspsB5OE4F1ucEv1x-hyn0roW5DCGmM3DU6T7Z8_2eg7f7u9flI3p-eXha3j4jwwTJqG5tQxvMpekorZuO17YikmDOGdNiYbnQZmE0lnXbsU4SzbVpiG6kNlRWpmJzcLXrHWP4LDZlNbhkbN9rb0NJiopaUsZEvUXpDjUxpBRtp8boBh03imC1Vax2itWkV_0oVnR6utz3l2aw7d_Lr9MJYDsgTZFf2ajWocRJVPqv9hs3YYiy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2789233784</pqid></control><display><type>article</type><title>Impact of cisplatin-induced acute kidney injury on long-term renal function in patients with solid tumors</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hino, Amiko ; Muto, Satoru ; Shimada, Yosuke ; Hori, Satoshi ; Isotani, Shuji ; Nagata, Masayoshi ; Horie, Shigeo</creator><creatorcontrib>Hino, Amiko ; Muto, Satoru ; Shimada, Yosuke ; Hori, Satoshi ; Isotani, Shuji ; Nagata, Masayoshi ; Horie, Shigeo</creatorcontrib><description><![CDATA[Background
The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the incidence and risk factors for CIA development, and if CIA is a useful predictor of long-term renal dysfunction after cisplatin treatment.
Methods
This was a retrospective, single-center, observational, longitudinal follow-up, large cohort study in adult patients with solid tumors treated with cisplatin-based systematic chemotherapy. Electronic medical records were used for all demographic and medical data. AKI was defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria. We assessed long-term renal dysfunction using %ΔeGFR/Y; (the last eGFR value during follow-up)—(the baseline eGFR)/(the baseline eGFR)/year of follow-up × 100.
Results
A total of 2191 patients received 8,482 cycles of cisplatin. CIA was observed 359 times (4.2%). Significant risk factors for developing CIA, using multiple linear regression analysis, included: cisplatin administration immediately before the onset of CIA (
p
< 0.01), liver cancer (
p
= 0.02), colon cancer (
p
= 0.04), hypertension (
p
= 0.03), high estimated glomerular filtration rate (eGFR) (
p
< 0.01), and high C-reactive protein (CRP) (
p
= 0.04). Significant risk factors for %ΔeGFR/Y, using multivariate linear regression analysis, included: esophageal cancer (
p
< 0.01), lung cancer (
p
< 0.01), pharyngeal cancer (
p
= 0.02), Head and neck cancer (
p
< 0.01), liver cancer (
p
= 0.02), potassium (
p
< 0.01), and CIA (
p
< 0.01).
Conclusions
To our knowledge, this is the first study to show that CIA is a significant predictive risk factor for long-term renal dysfunction after cisplatin administration. Effective strategies are needed to prevent CIA in cancer patients.]]></description><identifier>ISSN: 1342-1751</identifier><identifier>EISSN: 1437-7799</identifier><identifier>DOI: 10.1007/s10157-023-02324-2</identifier><identifier>PMID: 36941500</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Acute Kidney Injury - chemically induced ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - epidemiology ; Adult ; Antineoplastic Agents ; Cisplatin - adverse effects ; Cohort Studies ; Glomerular Filtration Rate ; Humans ; Kidney ; Liver Neoplasms ; Medicine ; Medicine & Public Health ; Nephrology ; Original Article ; Retrospective Studies ; Urology</subject><ispartof>Clinical and experimental nephrology, 2023-06, Vol.27 (6), p.506-518</ispartof><rights>The Author(s), under exclusive licence to The Japanese Society of Nephrology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to The Japanese Society of Nephrology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-8deb2b059cf228bf58e419105533a76e57ac6ca098df3f91a5acb1ab9ac294c43</citedby><cites>FETCH-LOGICAL-c371t-8deb2b059cf228bf58e419105533a76e57ac6ca098df3f91a5acb1ab9ac294c43</cites><orcidid>0000-0002-8612-8368</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10157-023-02324-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10157-023-02324-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36941500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hino, Amiko</creatorcontrib><creatorcontrib>Muto, Satoru</creatorcontrib><creatorcontrib>Shimada, Yosuke</creatorcontrib><creatorcontrib>Hori, Satoshi</creatorcontrib><creatorcontrib>Isotani, Shuji</creatorcontrib><creatorcontrib>Nagata, Masayoshi</creatorcontrib><creatorcontrib>Horie, Shigeo</creatorcontrib><title>Impact of cisplatin-induced acute kidney injury on long-term renal function in patients with solid tumors</title><title>Clinical and experimental nephrology</title><addtitle>Clin Exp Nephrol</addtitle><addtitle>Clin Exp Nephrol</addtitle><description><![CDATA[Background
The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the incidence and risk factors for CIA development, and if CIA is a useful predictor of long-term renal dysfunction after cisplatin treatment.
Methods
This was a retrospective, single-center, observational, longitudinal follow-up, large cohort study in adult patients with solid tumors treated with cisplatin-based systematic chemotherapy. Electronic medical records were used for all demographic and medical data. AKI was defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria. We assessed long-term renal dysfunction using %ΔeGFR/Y; (the last eGFR value during follow-up)—(the baseline eGFR)/(the baseline eGFR)/year of follow-up × 100.
Results
A total of 2191 patients received 8,482 cycles of cisplatin. CIA was observed 359 times (4.2%). Significant risk factors for developing CIA, using multiple linear regression analysis, included: cisplatin administration immediately before the onset of CIA (
p
< 0.01), liver cancer (
p
= 0.02), colon cancer (
p
= 0.04), hypertension (
p
= 0.03), high estimated glomerular filtration rate (eGFR) (
p
< 0.01), and high C-reactive protein (CRP) (
p
= 0.04). Significant risk factors for %ΔeGFR/Y, using multivariate linear regression analysis, included: esophageal cancer (
p
< 0.01), lung cancer (
p
< 0.01), pharyngeal cancer (
p
= 0.02), Head and neck cancer (
p
< 0.01), liver cancer (
p
= 0.02), potassium (
p
< 0.01), and CIA (
p
< 0.01).
Conclusions
To our knowledge, this is the first study to show that CIA is a significant predictive risk factor for long-term renal dysfunction after cisplatin administration. Effective strategies are needed to prevent CIA in cancer patients.]]></description><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - epidemiology</subject><subject>Adult</subject><subject>Antineoplastic Agents</subject><subject>Cisplatin - adverse effects</subject><subject>Cohort Studies</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Kidney</subject><subject>Liver Neoplasms</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Retrospective Studies</subject><subject>Urology</subject><issn>1342-1751</issn><issn>1437-7799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOwzAUhi0EglJ4AQbkkcXgS1zHI6q4SUgsMFuO4xSXxA6-CPXtSWlhZDg6R_q_8w8fABcEXxOMxU0imHCBMGXboRWiB2BGKiaQEFIeTjerKCKCkxNwmtIaY1xLLo_BCVvIinCMZ8A9DaM2GYYOGpfGXmfnkfNtMbaF2pRs4Ydrvd1A59clbmDwsA9-hbKNA4zW6x52xZvspsB5OE4F1ucEv1x-hyn0roW5DCGmM3DU6T7Z8_2eg7f7u9flI3p-eXha3j4jwwTJqG5tQxvMpekorZuO17YikmDOGdNiYbnQZmE0lnXbsU4SzbVpiG6kNlRWpmJzcLXrHWP4LDZlNbhkbN9rb0NJiopaUsZEvUXpDjUxpBRtp8boBh03imC1Vax2itWkV_0oVnR6utz3l2aw7d_Lr9MJYDsgTZFf2ajWocRJVPqv9hs3YYiy</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Hino, Amiko</creator><creator>Muto, Satoru</creator><creator>Shimada, Yosuke</creator><creator>Hori, Satoshi</creator><creator>Isotani, Shuji</creator><creator>Nagata, Masayoshi</creator><creator>Horie, Shigeo</creator><general>Springer Nature Singapore</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8612-8368</orcidid></search><sort><creationdate>20230601</creationdate><title>Impact of cisplatin-induced acute kidney injury on long-term renal function in patients with solid tumors</title><author>Hino, Amiko ; Muto, Satoru ; Shimada, Yosuke ; Hori, Satoshi ; Isotani, Shuji ; Nagata, Masayoshi ; Horie, Shigeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-8deb2b059cf228bf58e419105533a76e57ac6ca098df3f91a5acb1ab9ac294c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acute Kidney Injury - chemically induced</topic><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - epidemiology</topic><topic>Adult</topic><topic>Antineoplastic Agents</topic><topic>Cisplatin - adverse effects</topic><topic>Cohort Studies</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Kidney</topic><topic>Liver Neoplasms</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Retrospective Studies</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hino, Amiko</creatorcontrib><creatorcontrib>Muto, Satoru</creatorcontrib><creatorcontrib>Shimada, Yosuke</creatorcontrib><creatorcontrib>Hori, Satoshi</creatorcontrib><creatorcontrib>Isotani, Shuji</creatorcontrib><creatorcontrib>Nagata, Masayoshi</creatorcontrib><creatorcontrib>Horie, Shigeo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hino, Amiko</au><au>Muto, Satoru</au><au>Shimada, Yosuke</au><au>Hori, Satoshi</au><au>Isotani, Shuji</au><au>Nagata, Masayoshi</au><au>Horie, Shigeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of cisplatin-induced acute kidney injury on long-term renal function in patients with solid tumors</atitle><jtitle>Clinical and experimental nephrology</jtitle><stitle>Clin Exp Nephrol</stitle><addtitle>Clin Exp Nephrol</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>27</volume><issue>6</issue><spage>506</spage><epage>518</epage><pages>506-518</pages><issn>1342-1751</issn><eissn>1437-7799</eissn><abstract><![CDATA[Background
The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the incidence and risk factors for CIA development, and if CIA is a useful predictor of long-term renal dysfunction after cisplatin treatment.
Methods
This was a retrospective, single-center, observational, longitudinal follow-up, large cohort study in adult patients with solid tumors treated with cisplatin-based systematic chemotherapy. Electronic medical records were used for all demographic and medical data. AKI was defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria. We assessed long-term renal dysfunction using %ΔeGFR/Y; (the last eGFR value during follow-up)—(the baseline eGFR)/(the baseline eGFR)/year of follow-up × 100.
Results
A total of 2191 patients received 8,482 cycles of cisplatin. CIA was observed 359 times (4.2%). Significant risk factors for developing CIA, using multiple linear regression analysis, included: cisplatin administration immediately before the onset of CIA (
p
< 0.01), liver cancer (
p
= 0.02), colon cancer (
p
= 0.04), hypertension (
p
= 0.03), high estimated glomerular filtration rate (eGFR) (
p
< 0.01), and high C-reactive protein (CRP) (
p
= 0.04). Significant risk factors for %ΔeGFR/Y, using multivariate linear regression analysis, included: esophageal cancer (
p
< 0.01), lung cancer (
p
< 0.01), pharyngeal cancer (
p
= 0.02), Head and neck cancer (
p
< 0.01), liver cancer (
p
= 0.02), potassium (
p
< 0.01), and CIA (
p
< 0.01).
Conclusions
To our knowledge, this is the first study to show that CIA is a significant predictive risk factor for long-term renal dysfunction after cisplatin administration. Effective strategies are needed to prevent CIA in cancer patients.]]></abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>36941500</pmid><doi>10.1007/s10157-023-02324-2</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-8612-8368</orcidid></addata></record> |
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| ispartof | Clinical and experimental nephrology, 2023-06, Vol.27 (6), p.506-518 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acute Kidney Injury - chemically induced Acute Kidney Injury - diagnosis Acute Kidney Injury - epidemiology Adult Antineoplastic Agents Cisplatin - adverse effects Cohort Studies Glomerular Filtration Rate Humans Kidney Liver Neoplasms Medicine Medicine & Public Health Nephrology Original Article Retrospective Studies Urology |
| title | Impact of cisplatin-induced acute kidney injury on long-term renal function in patients with solid tumors |
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