Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation

Unlike other nucleotide oligomerization domain-like receptors, Nlrp10 lacks a canonical leucine-rich repeat domain, suggesting that it is incapable of signal sensing and inflammasome formation. Here we show that mouse Nlrp10 is expressed in distal colonic intestinal epithelial cells (IECs) and modul...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2023-04, Vol.24 (4), p.585-594
Hauptverfasser:	Zheng, Danping, Mohapatra, Gayatree, Kern, Lara, He, Yiming, Shmueli, Merav D., Valdés-Mas, Rafael, Kolodziejczyk, Aleksandra A., Próchnicki, Tomasz, Vasconcelos, Matilde B., Schorr, Lena, Hertel, Franziska, Lee, Ye Seul, Rufino, Miguel Camacho, Ceddaha, Emmanuelle, Shimshy, Sandy, Hodgetts, Ryan James, Dori-Bachash, Mally, Kleimeyer, Christian, Goldenberg, Kim, Heinemann, Melina, Stettner, Noa, Harmelin, Alon, Shapiro, Hagit, Puschhof, Jens, Chen, Minhu, Flavell, Richard A., Latz, Eicke, Merbl, Yifat, Abdeen, Suhaib K., Elinav, Eran
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/249/2510/257 631/250/256/2177 631/250/262/2106/2517 Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biomedical and Life Sciences Biomedicine Carrier Proteins - genetics Carrier Proteins - metabolism Caspase 1 - metabolism Caspase-1 Colitis Cytokines Dextran Epithelial cells Humans Immunology Infectious Diseases Inflammasomes Inflammasomes - metabolism Inflammation Inflammatory bowel disease Interleukin 18 Interleukin-1beta - metabolism Intestine Letter Mice Microbiomes NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Oligomerization Sodium sulfate Sulfates
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!