Glutathione‐Induced In Situ Michael Addition between Nanoparticles for Pyroptosis and Immunotherapy
Most tumor treatments will fail when ignoring competition and cooperation between each cancer cell and its microenvironment. Inspired by game theory, therapeutic agents can be introduced to compete for intracellular molecules to disrupt the cooperation between molecules and cells. Biomineralized oxi...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2023-05, Vol.62 (20), p.e202301866-n/a |
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| creator | Zhen, Wenyao Liu, Yang An, Shangjie Jiang, Xiue |
| description | Most tumor treatments will fail when ignoring competition and cooperation between each cancer cell and its microenvironment. Inspired by game theory, therapeutic agents can be introduced to compete for intracellular molecules to disrupt the cooperation between molecules and cells. Biomineralized oxidized (−)‐epigallocatechin‐3‐o‐gallate (EGCG)–molybdenum ion coordination nanoparticles were prepared for disrupting redox equilibria and simultaneously reacting with intracellular GSH in a Michael addition to form large aggregates that can mechanically disrupt endosomal and plasma membranes, stimulating pyroptosis and anti‐tumor immunological responses for versatile inhibition of different types of tumors. This design disrupts the cooperation between molecules and between cancer and immune cells, achieving an optimal payoff in competition and cooperation in cancer therapy.
Epigallocatechin‐3‐o‐gallate (EGCG)–molybdenum ion coordination nanoparticles were prepared by biomineralization. In cancer cells, they disrupt the redox equilibrium and simultaneously compete for and consume intracellular glutathione (GSH) to form large aggregates, which mechanically disrupt the endosomal and plasma membranes, thus inducing pyroptosis and releasing inflammatory factors for activating immunological responses. |
| doi_str_mv | 10.1002/anie.202301866 |
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Epigallocatechin‐3‐o‐gallate (EGCG)–molybdenum ion coordination nanoparticles were prepared by biomineralization. In cancer cells, they disrupt the redox equilibrium and simultaneously compete for and consume intracellular glutathione (GSH) to form large aggregates, which mechanically disrupt the endosomal and plasma membranes, thus inducing pyroptosis and releasing inflammatory factors for activating immunological responses.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.202301866</identifier><identifier>PMID: 36935404</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Cancer ; Cancer Therapy ; Competition ; Cooperation ; Epigallocatechin-3-gallate ; Game theory ; Glutathione ; Immune system ; Immunology ; Immunotherapy ; Intracellular ; Microenvironments ; Molybdenum ; Nanoparticles ; Nanotechnology ; Oxidation-Reduction ; Pharmacology ; Plasma membranes ; Polyphenols ; Pyroptosis ; Tumors</subject><ispartof>Angewandte Chemie International Edition, 2023-05, Vol.62 (20), p.e202301866-n/a</ispartof><rights>2023 Wiley‐VCH GmbH</rights><rights>2023 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3736-fef6f86502f93b6ddeea91100f72a1b04aa264faac16c2ebd5efb8d6ae37bba63</citedby><cites>FETCH-LOGICAL-c3736-fef6f86502f93b6ddeea91100f72a1b04aa264faac16c2ebd5efb8d6ae37bba63</cites><orcidid>0000-0002-0194-1553 ; 0000-0002-7619-0109</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.202301866$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.202301866$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36935404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhen, Wenyao</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>An, Shangjie</creatorcontrib><creatorcontrib>Jiang, Xiue</creatorcontrib><title>Glutathione‐Induced In Situ Michael Addition between Nanoparticles for Pyroptosis and Immunotherapy</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Most tumor treatments will fail when ignoring competition and cooperation between each cancer cell and its microenvironment. Inspired by game theory, therapeutic agents can be introduced to compete for intracellular molecules to disrupt the cooperation between molecules and cells. Biomineralized oxidized (−)‐epigallocatechin‐3‐o‐gallate (EGCG)–molybdenum ion coordination nanoparticles were prepared for disrupting redox equilibria and simultaneously reacting with intracellular GSH in a Michael addition to form large aggregates that can mechanically disrupt endosomal and plasma membranes, stimulating pyroptosis and anti‐tumor immunological responses for versatile inhibition of different types of tumors. This design disrupts the cooperation between molecules and between cancer and immune cells, achieving an optimal payoff in competition and cooperation in cancer therapy.
Epigallocatechin‐3‐o‐gallate (EGCG)–molybdenum ion coordination nanoparticles were prepared by biomineralization. In cancer cells, they disrupt the redox equilibrium and simultaneously compete for and consume intracellular glutathione (GSH) to form large aggregates, which mechanically disrupt the endosomal and plasma membranes, thus inducing pyroptosis and releasing inflammatory factors for activating immunological responses.</description><subject>Cancer</subject><subject>Cancer Therapy</subject><subject>Competition</subject><subject>Cooperation</subject><subject>Epigallocatechin-3-gallate</subject><subject>Game theory</subject><subject>Glutathione</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Immunotherapy</subject><subject>Intracellular</subject><subject>Microenvironments</subject><subject>Molybdenum</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Oxidation-Reduction</subject><subject>Pharmacology</subject><subject>Plasma membranes</subject><subject>Polyphenols</subject><subject>Pyroptosis</subject><subject>Tumors</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhy1ERUvplSOyxIVLFv9JHOe4qkq7UmmRoGfLicdaV4kdbEfV3voIPCNPUq-2FIkLp5nDN59m5ofQe0pWlBD2WXsHK0YYJ1QK8Qqd0IbRirctf136mvOqlQ09Rm9Tui-8lES8QcdcdLypSX2C4HJcss5bFzz8fvy18WYZwOCNx99dXvBXN2w1jHhtjMuFwT3kBwCPb7QPs47ZDSMkbEPE33YxzDkkl7D2xTBNiw95C1HPu3foyOoxwdlzPUV3Xy5-nF9V17eXm_P1dTXwlovKghVWioYw2_FeGAOgO1rutC3TtCe11kzUVuuBioFBbxqwvTRCA2_7Xgt-ij4dvHMMPxdIWU0uDTCO2kNYkmKtLB-gtN6jH_9B78MSfdlOMUlk3ZKu6wq1OlBDDClFsGqObtJxpyhR-wDUPgD1EkAZ-PCsXfoJzAv-5-MF6A7Agxth9x-dWt9sLv7KnwA11pUL</recordid><startdate>20230508</startdate><enddate>20230508</enddate><creator>Zhen, Wenyao</creator><creator>Liu, Yang</creator><creator>An, Shangjie</creator><creator>Jiang, Xiue</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0194-1553</orcidid><orcidid>https://orcid.org/0000-0002-7619-0109</orcidid></search><sort><creationdate>20230508</creationdate><title>Glutathione‐Induced In Situ Michael Addition between Nanoparticles for Pyroptosis and Immunotherapy</title><author>Zhen, Wenyao ; Liu, Yang ; An, Shangjie ; Jiang, Xiue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3736-fef6f86502f93b6ddeea91100f72a1b04aa264faac16c2ebd5efb8d6ae37bba63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cancer</topic><topic>Cancer Therapy</topic><topic>Competition</topic><topic>Cooperation</topic><topic>Epigallocatechin-3-gallate</topic><topic>Game theory</topic><topic>Glutathione</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Immunotherapy</topic><topic>Intracellular</topic><topic>Microenvironments</topic><topic>Molybdenum</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Oxidation-Reduction</topic><topic>Pharmacology</topic><topic>Plasma membranes</topic><topic>Polyphenols</topic><topic>Pyroptosis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhen, Wenyao</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>An, Shangjie</creatorcontrib><creatorcontrib>Jiang, Xiue</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhen, Wenyao</au><au>Liu, Yang</au><au>An, Shangjie</au><au>Jiang, Xiue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione‐Induced In Situ Michael Addition between Nanoparticles for Pyroptosis and Immunotherapy</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2023-05-08</date><risdate>2023</risdate><volume>62</volume><issue>20</issue><spage>e202301866</spage><epage>n/a</epage><pages>e202301866-n/a</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Most tumor treatments will fail when ignoring competition and cooperation between each cancer cell and its microenvironment. Inspired by game theory, therapeutic agents can be introduced to compete for intracellular molecules to disrupt the cooperation between molecules and cells. Biomineralized oxidized (−)‐epigallocatechin‐3‐o‐gallate (EGCG)–molybdenum ion coordination nanoparticles were prepared for disrupting redox equilibria and simultaneously reacting with intracellular GSH in a Michael addition to form large aggregates that can mechanically disrupt endosomal and plasma membranes, stimulating pyroptosis and anti‐tumor immunological responses for versatile inhibition of different types of tumors. This design disrupts the cooperation between molecules and between cancer and immune cells, achieving an optimal payoff in competition and cooperation in cancer therapy.
Epigallocatechin‐3‐o‐gallate (EGCG)–molybdenum ion coordination nanoparticles were prepared by biomineralization. In cancer cells, they disrupt the redox equilibrium and simultaneously compete for and consume intracellular glutathione (GSH) to form large aggregates, which mechanically disrupt the endosomal and plasma membranes, thus inducing pyroptosis and releasing inflammatory factors for activating immunological responses.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36935404</pmid><doi>10.1002/anie.202301866</doi><tpages>9</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0002-0194-1553</orcidid><orcidid>https://orcid.org/0000-0002-7619-0109</orcidid></addata></record> |
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| subjects | Cancer Cancer Therapy Competition Cooperation Epigallocatechin-3-gallate Game theory Glutathione Immune system Immunology Immunotherapy Intracellular Microenvironments Molybdenum Nanoparticles Nanotechnology Oxidation-Reduction Pharmacology Plasma membranes Polyphenols Pyroptosis Tumors |
| title | Glutathione‐Induced In Situ Michael Addition between Nanoparticles for Pyroptosis and Immunotherapy |
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