Associations Between Body Composition and Sensorineural Hearing Loss Among Adults Based on the UK Biobank
Objective To explore the association between body composition and sensorineural hearing loss (SNHL). Study Design Cross‐sectional study, prospective study and Mendelian randomization (MR) analyses. Setting UK Biobank. Methods This cross‐sectional study included 147,296 adult participants with comple...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2023-10, Vol.169 (4), p.875-883 |
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| creator | Pang, Wendu Li, Junhong Qiu, Ke Yi, Xiaowei Cheng, Danni Rao, Yufang Song, Yao Deng, Di Mao, Minzi Li, Xiaohong Ma, Ning Chen, Daibo Luo, Yi Xu, Wei Ren, Jianjun Zhao, Yu |
| description | Objective
To explore the association between body composition and sensorineural hearing loss (SNHL).
Study Design
Cross‐sectional study, prospective study and Mendelian randomization (MR) analyses.
Setting
UK Biobank.
Methods
This cross‐sectional study included 147,296 adult participants with complete data on body composition and the speech‐reception‐threshold (SRT) test. We further conducted a prospective study with 129,905 participants without SNHL at baseline and followed up to 15 years to explore the association between body composition and new‐onset SNHL. Multivariable logistic regression and Cox regression models were used. Subgroup analyses stratified by age and sex were performed. We further assessed the causal association between body composition and SNHL using two‐sample MR analyses.
Results
Our cross‐sectional study revealed that fat percentage, especially leg (odds ratio [OR] 1.46, p = .029) and arm (OR 1.43, p = .004), were significant risk factors for SNHL. However, fat‐free mass, especially in the arm (OR 0.27, p |
| doi_str_mv | 10.1002/ohn.323 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2788800071</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2788800071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2793-ab167f04b91e0b3eac66efec154e8b16c6ad1875c4c5c44b5117f3b6930552413</originalsourceid><addsrcrecordid>eNp1kN9LwzAQx4Mobv7A_0DypiCdSZM27WM31InDPeieQ5peXbRtZtMy9t-bsumbD8cd3Oc-cF-EriiZUELCe7tuJixkR2hMSSqCOKHiGI0JTXkQpWkyQmfOfRJC4liIUzRicco452KMTOac1UZ1xjYOT6HbAjR4aosdntl6Y50ZNlg1BX6DxtnWNNC3qsJzUH7-wAvrHM5q68es6KvOS5SDAvujbg149YKnxuaq-bpAJ6WqHFwe-jlaPT68z-bBYvn0PMsWgQ5FygKV01iUhOcpBZIzUDqOoQRNIw6J3-lYFTQRkebaF88jSkXJcv8QiaKQU3aObvfeTWu_e3CdrI3TUFWqAds7GYokSXwUYkBv9qhu_RctlHLTmlq1O0mJHHKVPlfpc_Xk9UHa5zUUf9xvkB642wNbU8HuP49czl8H3Q-bKoDD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2788800071</pqid></control><display><type>article</type><title>Associations Between Body Composition and Sensorineural Hearing Loss Among Adults Based on the UK Biobank</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Pang, Wendu ; Li, Junhong ; Qiu, Ke ; Yi, Xiaowei ; Cheng, Danni ; Rao, Yufang ; Song, Yao ; Deng, Di ; Mao, Minzi ; Li, Xiaohong ; Ma, Ning ; Chen, Daibo ; Luo, Yi ; Xu, Wei ; Ren, Jianjun ; Zhao, Yu</creator><creatorcontrib>Pang, Wendu ; Li, Junhong ; Qiu, Ke ; Yi, Xiaowei ; Cheng, Danni ; Rao, Yufang ; Song, Yao ; Deng, Di ; Mao, Minzi ; Li, Xiaohong ; Ma, Ning ; Chen, Daibo ; Luo, Yi ; Xu, Wei ; Ren, Jianjun ; Zhao, Yu</creatorcontrib><description>Objective
To explore the association between body composition and sensorineural hearing loss (SNHL).
Study Design
Cross‐sectional study, prospective study and Mendelian randomization (MR) analyses.
Setting
UK Biobank.
Methods
This cross‐sectional study included 147,296 adult participants with complete data on body composition and the speech‐reception‐threshold (SRT) test. We further conducted a prospective study with 129,905 participants without SNHL at baseline and followed up to 15 years to explore the association between body composition and new‐onset SNHL. Multivariable logistic regression and Cox regression models were used. Subgroup analyses stratified by age and sex were performed. We further assessed the causal association between body composition and SNHL using two‐sample MR analyses.
Results
Our cross‐sectional study revealed that fat percentage, especially leg (odds ratio [OR] 1.46, p = .029) and arm (OR 1.43, p = .004), were significant risk factors for SNHL. However, fat‐free mass, especially in the arm (OR 0.27, p < .001) and leg (OR 0.58, p < .001) showed significant protective effects against SNHL, which was substantially consistent with the results of the prospective study. In addition, we found that young women with SNHL were more susceptible to body composition indicators. However, MR analyses revealed no evidence of significant causal association.
Conclusion
Fat percentage, especially in the leg and arm, was a significant risk factor for SNHL, whereas fat‐free mass, especially in the leg and arm, had significant protective effects against SNHL, however, these associations may not be causal.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1002/ohn.323</identifier><identifier>PMID: 36934447</identifier><language>eng</language><publisher>England</publisher><subject>body composition ; body fat free mass ; body fat percentage ; sensorineural hearing loss ; waist‐to‐hip ratio</subject><ispartof>Otolaryngology-head and neck surgery, 2023-10, Vol.169 (4), p.875-883</ispartof><rights>2023 American Academy of Otolaryngology–Head and Neck Surgery Foundation.</rights><rights>2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2793-ab167f04b91e0b3eac66efec154e8b16c6ad1875c4c5c44b5117f3b6930552413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fohn.323$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fohn.323$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36934447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pang, Wendu</creatorcontrib><creatorcontrib>Li, Junhong</creatorcontrib><creatorcontrib>Qiu, Ke</creatorcontrib><creatorcontrib>Yi, Xiaowei</creatorcontrib><creatorcontrib>Cheng, Danni</creatorcontrib><creatorcontrib>Rao, Yufang</creatorcontrib><creatorcontrib>Song, Yao</creatorcontrib><creatorcontrib>Deng, Di</creatorcontrib><creatorcontrib>Mao, Minzi</creatorcontrib><creatorcontrib>Li, Xiaohong</creatorcontrib><creatorcontrib>Ma, Ning</creatorcontrib><creatorcontrib>Chen, Daibo</creatorcontrib><creatorcontrib>Luo, Yi</creatorcontrib><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Ren, Jianjun</creatorcontrib><creatorcontrib>Zhao, Yu</creatorcontrib><title>Associations Between Body Composition and Sensorineural Hearing Loss Among Adults Based on the UK Biobank</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>Objective
To explore the association between body composition and sensorineural hearing loss (SNHL).
Study Design
Cross‐sectional study, prospective study and Mendelian randomization (MR) analyses.
Setting
UK Biobank.
Methods
This cross‐sectional study included 147,296 adult participants with complete data on body composition and the speech‐reception‐threshold (SRT) test. We further conducted a prospective study with 129,905 participants without SNHL at baseline and followed up to 15 years to explore the association between body composition and new‐onset SNHL. Multivariable logistic regression and Cox regression models were used. Subgroup analyses stratified by age and sex were performed. We further assessed the causal association between body composition and SNHL using two‐sample MR analyses.
Results
Our cross‐sectional study revealed that fat percentage, especially leg (odds ratio [OR] 1.46, p = .029) and arm (OR 1.43, p = .004), were significant risk factors for SNHL. However, fat‐free mass, especially in the arm (OR 0.27, p < .001) and leg (OR 0.58, p < .001) showed significant protective effects against SNHL, which was substantially consistent with the results of the prospective study. In addition, we found that young women with SNHL were more susceptible to body composition indicators. However, MR analyses revealed no evidence of significant causal association.
Conclusion
Fat percentage, especially in the leg and arm, was a significant risk factor for SNHL, whereas fat‐free mass, especially in the leg and arm, had significant protective effects against SNHL, however, these associations may not be causal.</description><subject>body composition</subject><subject>body fat free mass</subject><subject>body fat percentage</subject><subject>sensorineural hearing loss</subject><subject>waist‐to‐hip ratio</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kN9LwzAQx4Mobv7A_0DypiCdSZM27WM31InDPeieQ5peXbRtZtMy9t-bsumbD8cd3Oc-cF-EriiZUELCe7tuJixkR2hMSSqCOKHiGI0JTXkQpWkyQmfOfRJC4liIUzRicco452KMTOac1UZ1xjYOT6HbAjR4aosdntl6Y50ZNlg1BX6DxtnWNNC3qsJzUH7-wAvrHM5q68es6KvOS5SDAvujbg149YKnxuaq-bpAJ6WqHFwe-jlaPT68z-bBYvn0PMsWgQ5FygKV01iUhOcpBZIzUDqOoQRNIw6J3-lYFTQRkebaF88jSkXJcv8QiaKQU3aObvfeTWu_e3CdrI3TUFWqAds7GYokSXwUYkBv9qhu_RctlHLTmlq1O0mJHHKVPlfpc_Xk9UHa5zUUf9xvkB642wNbU8HuP49czl8H3Q-bKoDD</recordid><startdate>202310</startdate><enddate>202310</enddate><creator>Pang, Wendu</creator><creator>Li, Junhong</creator><creator>Qiu, Ke</creator><creator>Yi, Xiaowei</creator><creator>Cheng, Danni</creator><creator>Rao, Yufang</creator><creator>Song, Yao</creator><creator>Deng, Di</creator><creator>Mao, Minzi</creator><creator>Li, Xiaohong</creator><creator>Ma, Ning</creator><creator>Chen, Daibo</creator><creator>Luo, Yi</creator><creator>Xu, Wei</creator><creator>Ren, Jianjun</creator><creator>Zhao, Yu</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202310</creationdate><title>Associations Between Body Composition and Sensorineural Hearing Loss Among Adults Based on the UK Biobank</title><author>Pang, Wendu ; Li, Junhong ; Qiu, Ke ; Yi, Xiaowei ; Cheng, Danni ; Rao, Yufang ; Song, Yao ; Deng, Di ; Mao, Minzi ; Li, Xiaohong ; Ma, Ning ; Chen, Daibo ; Luo, Yi ; Xu, Wei ; Ren, Jianjun ; Zhao, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2793-ab167f04b91e0b3eac66efec154e8b16c6ad1875c4c5c44b5117f3b6930552413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>body composition</topic><topic>body fat free mass</topic><topic>body fat percentage</topic><topic>sensorineural hearing loss</topic><topic>waist‐to‐hip ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pang, Wendu</creatorcontrib><creatorcontrib>Li, Junhong</creatorcontrib><creatorcontrib>Qiu, Ke</creatorcontrib><creatorcontrib>Yi, Xiaowei</creatorcontrib><creatorcontrib>Cheng, Danni</creatorcontrib><creatorcontrib>Rao, Yufang</creatorcontrib><creatorcontrib>Song, Yao</creatorcontrib><creatorcontrib>Deng, Di</creatorcontrib><creatorcontrib>Mao, Minzi</creatorcontrib><creatorcontrib>Li, Xiaohong</creatorcontrib><creatorcontrib>Ma, Ning</creatorcontrib><creatorcontrib>Chen, Daibo</creatorcontrib><creatorcontrib>Luo, Yi</creatorcontrib><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Ren, Jianjun</creatorcontrib><creatorcontrib>Zhao, Yu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pang, Wendu</au><au>Li, Junhong</au><au>Qiu, Ke</au><au>Yi, Xiaowei</au><au>Cheng, Danni</au><au>Rao, Yufang</au><au>Song, Yao</au><au>Deng, Di</au><au>Mao, Minzi</au><au>Li, Xiaohong</au><au>Ma, Ning</au><au>Chen, Daibo</au><au>Luo, Yi</au><au>Xu, Wei</au><au>Ren, Jianjun</au><au>Zhao, Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations Between Body Composition and Sensorineural Hearing Loss Among Adults Based on the UK Biobank</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2023-10</date><risdate>2023</risdate><volume>169</volume><issue>4</issue><spage>875</spage><epage>883</epage><pages>875-883</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Objective
To explore the association between body composition and sensorineural hearing loss (SNHL).
Study Design
Cross‐sectional study, prospective study and Mendelian randomization (MR) analyses.
Setting
UK Biobank.
Methods
This cross‐sectional study included 147,296 adult participants with complete data on body composition and the speech‐reception‐threshold (SRT) test. We further conducted a prospective study with 129,905 participants without SNHL at baseline and followed up to 15 years to explore the association between body composition and new‐onset SNHL. Multivariable logistic regression and Cox regression models were used. Subgroup analyses stratified by age and sex were performed. We further assessed the causal association between body composition and SNHL using two‐sample MR analyses.
Results
Our cross‐sectional study revealed that fat percentage, especially leg (odds ratio [OR] 1.46, p = .029) and arm (OR 1.43, p = .004), were significant risk factors for SNHL. However, fat‐free mass, especially in the arm (OR 0.27, p < .001) and leg (OR 0.58, p < .001) showed significant protective effects against SNHL, which was substantially consistent with the results of the prospective study. In addition, we found that young women with SNHL were more susceptible to body composition indicators. However, MR analyses revealed no evidence of significant causal association.
Conclusion
Fat percentage, especially in the leg and arm, was a significant risk factor for SNHL, whereas fat‐free mass, especially in the leg and arm, had significant protective effects against SNHL, however, these associations may not be causal.</abstract><cop>England</cop><pmid>36934447</pmid><doi>10.1002/ohn.323</doi><tpages>9</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | body composition body fat free mass body fat percentage sensorineural hearing loss waist‐to‐hip ratio |
| title | Associations Between Body Composition and Sensorineural Hearing Loss Among Adults Based on the UK Biobank |
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