Preoperative administration of a biomimetic platelet nanodrug enhances postoperative drug delivery by bypassing thrombus

[Display omitted] The postoperative thrombus attached to the damaged blood vessels severely obstructs drugs from crossing the damaged blood–brain barrier (BBB) and targeting residual glioma cells around surgical margins, leading to glioblastoma (GBM) recurrence. A thrombus-bypassing, BBB-crossing, a...

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Veröffentlicht in:	International journal of pharmaceutics 2023-04, Vol.636, p.122851-122851, Article 122851
Hauptverfasser:	Ji, Jingsen, Lian, Weidong, Zhang, Yuxuan, Lin, Dongni, Wang, Jihui, Mo, Yunzhao, Xu, Xiangdong, Hou, Chongxian, Ma, Chengcheng, Zheng, Yaofeng, Chen, Jiawen, Zhong, Jiasheng, Zhang, Fabing, Ke, Yiquan, Chen, Huajian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomimetics Blood Platelets - pathology Blood-Brain Barrier Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain Neoplasms - surgery Cell Line, Tumor Drug Delivery Systems Glioblastoma - drug therapy Glioblastoma - pathology Glioblastoma - surgery Glioblastoma resection Margins of Excision Mice Nanoparticles - therapeutic use Platelet membrane Postoperative drug delivery Preoperative administration Thrombosis - drug therapy
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