Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 1: Effects of Polymer and Drug Chiralities

We examined the effects of the polymer-additive and drug chiralities on the ketoprofen (KTP) supersaturation region using temperature-variable nuclear magnetic resonance (NMR). Quantitative NMR analysis revealed that the racemic KTP and corresponding S-enantiomer (rac- and s-KTP) exhibited similar a...

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Veröffentlicht in:	Molecular pharmaceutics 2023-04, Vol.20 (4), p.1861-1871
Hauptverfasser:	Ueda, Keisuke, Higashi, Kenjirou, Moribe, Kunikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Ketoprofen Magnetic Resonance Spectroscopy Polymers - chemistry Povidone - chemistry Solubility Temperature
Online-Zugang:	Volltext
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