Synthesis of Sulfilimines via Selective S–C Bond Formation in Water

Synthesis of Sulfilimines via Selective S–C Bond Formation in Water

Sulfilimines are valuable compounds both in organic synthesis and in pharmaceuticals. Here we developed a mild and simplified method for preparation of sulfilimines via selective S–C bond formation rather than traditional S–N bond formation. The method is both attractive and useful for the following...

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Veröffentlicht in:Organic letters 2023-03, Vol.25 (12), p.2134-2138
Hauptverfasser: Chen, Yue, Fang, Dong-mei, Huang, He-sen, Nie, Xiao-kang, Zhang, Shi-qi, Cui, Xin, Tang, Zhuo, Li, Guang-xun
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container_end_page 2138
container_issue 12
container_start_page 2134
container_title Organic letters
container_volume 25
creator Chen, Yue
Fang, Dong-mei
Huang, He-sen
Nie, Xiao-kang
Zhang, Shi-qi
Cui, Xin
Tang, Zhuo
Li, Guang-xun
description Sulfilimines are valuable compounds both in organic synthesis and in pharmaceuticals. Here we developed a mild and simplified method for preparation of sulfilimines via selective S–C bond formation rather than traditional S–N bond formation. The method is both attractive and useful for the following reasons: it uses a readily available alkylation reagent such alkyl bromide or alkyl iodide, it uses water as solvent, it is easy to perform, and it is convenient for late-stage diversification of drugs.
doi_str_mv 10.1021/acs.orglett.3c00604
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title Synthesis of Sulfilimines via Selective S–C Bond Formation in Water
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