The autocrine glycosylated-GREM1 interacts with TGFB1 to suppress TGFβ/BMP/SMAD-mediated EMT partially by inhibiting MYL9 transactivation in urinary carcinoma

Urothelial carcinoma (UC) is a common disease in developed counties. This study aimed to identify autocrine roles and signaling pathways of gremlin 1, DAN family BMP antagonist (GREM1), which inhibits tumor growth and epithelial-mesenchymal transition (EMT) in UC. Systematic in vitro and in vivo stu...

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Veröffentlicht in:	Cellular oncology (Dordrecht) 2023-08, Vol.46 (4), p.933-951
Hauptverfasser:	Chan, Ti-Chun, Pan, Cheng-Tang, Hsieh, Hsin-Yu, Vejvisithsakul, Pichpisith Pierre, Wei, Ren-Jie, Yeh, Bi-Wen, Wu, Wen-Jeng, Chen, Lih-Ren, Shiao, Meng-Shin, Li, Chien-Feng, Shiue, Yow-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Angiogenesis Animal models Animals Autocrine signalling Cancer Carcinoma, Transitional Cell - genetics Cell culture Cell growth Cell migration Cell proliferation Dan protein Epithelial-Mesenchymal Transition - genetics Genetic engineering Gremlin protein Immunohistochemistry Metastases Metastasis Mice Myosin NF-κB protein Smad protein Transcriptional Activation Transforming Growth Factor beta - metabolism Transforming growth factor-b1 Tumor cell lines Tumor necrosis factor-TNF Tumor suppressor genes Urinary bladder Urinary bladder carcinoma Urinary Bladder Neoplasms - pathology Urothelial carcinoma
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